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公开(公告)号：US20160318928A1
公开(公告)日：2016-11-03
申请号：US15107652
申请日：2014-12-23
发明人： Derek J. Norris , George V. Delucca , Ashvinikumar V. Gavai , Claude A. Quesnelle , Patrice Gill , Daniel O'Malley , Wayne Vaccaro , Francis Y. Lee , Mikkel V. DeBenedetto , Andrew P. Degnan , Haiquan Fang , Matthew D. Hill , Hong Huang , William D. Schmitz , John E. Starrett, JR. , Wen-Ching Han , John S. Tokarski , Sunil Kumar Mandal
IPC分类号： C07D471/04 , A61K31/501 , A61K31/506 , A61K31/437 , A61K31/444
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/501 , A61K31/506
摘要： The present invention is directed to tricyclic compounds (I), pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20160176864A1
公开(公告)日：2016-06-23
申请号：US14580355
申请日：2014-12-23
发明人： Derek J. Norris , George V. Delucca , Ashvinikumar V. Gavai , Claude A. Quesnelle , Patrice Gill , Daniel O'Malley , Wayne Vaccaro , Francis Y. Lee , Mikkel V. DeBenedetto , Andrew P. Degnan , Haiquan Fang , Matthew D. Hill , Hong Huang , William D. Schmitz , John E. Starrett, JR. , Wen-Ching Han , John S. Tokarski , Sunil Kumar Mandal
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09725449B2
公开(公告)日：2017-08-08
申请号：US15150492
申请日：2016-05-10
发明人： Derek J. Norris , Wayne Vaccaro , Mikkel V. DeBenedetto , Andrew P. Degnan , George V. Delucca , Jeffrey A. Deskus , Wen-Ching Han , Godwin Kwame Kumi , William D. Schmitz , John E. Starrett, Jr. , Matthew D. Hill , Hong Huang
IPC分类号： C07D471/14 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61K31/675 , A61K31/683 , C07D519/00 , C07F9/6561
CPC分类号： C07D471/14 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61K31/675 , A61K31/683 , C07D519/00 , C07F9/6561
摘要： The present invention is directed to tricyclic compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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![5H-pyrido[3,2-B]indole compounds as anticancer agents](/abs-image/US/2019/01/08/US10174024B2/abs.jpg.150x150.jpg)
公开(公告)号：US10174024B2
公开(公告)日：2019-01-08
申请号：US15573151
申请日：2016-05-11
发明人： Wen-Ching Han , Andrew P. Degnan , Jeffrey A. Deskus , Ashvinikumar V. Gavai , Patrice Gill , William D. Schmitz , John E. Starrett, Jr.
IPC分类号： C07D471/04
摘要： The present invention is directed to tricyclic compounds of formula (I), pharmaceutically acceptable compositions comprising compounds of the invention and said compositions for use in methods for the treatment of various disorders in particular cancer.
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公开(公告)号：US09751879B2
公开(公告)日：2017-09-05
申请号：US15219611
申请日：2016-07-26
发明人： Derek J. Norris , George V. Delucca , Ashvinikumar V. Gavai , Claude A. Quesnelle , Patrice Gill , Daniel O'Malley , Wayne Vaccaro , Francis Y. Lee , Mikkel V. DeBenedetto , Andrew P. Degnan , Haiquan Fang , Matthew D. Hill , Hong Huang , William D. Schmitz , John E. Starrett, Jr. , Wen-Ching Han , John S. Tokarski , Sunil Kumar Mandal
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20160333013A1
公开(公告)日：2016-11-17
申请号：US15150492
申请日：2016-05-10
发明人： Derek J. Norris , Wayne Vaccaro , Mikkel V. DeBenedetto , Andrew P. Degnan , George V. Delucca , Jeffrey A. Deskus , Wen-Ching Han , Godwin Kwame Kumi , William D. Schmitz , John E. Starrett, JR. , Matthew D. Hill , Hong Huang
IPC分类号： C07D471/14 , A61K31/5377 , A61K31/496 , A61K31/444 , A61K31/541 , A61K31/675 , A61K31/4545 , C07D519/00 , A61K31/439 , A61K31/554 , C07F9/6561 , A61K31/683 , A61K31/4375 , A61K31/519
CPC分类号： C07D471/14 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61K31/675 , A61K31/683 , C07D519/00 , C07F9/6561
摘要： The present invention is directed to tricyclic compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 其中所有取代基在本文中定义，以及包含本发明化合物的药学上可接受的组合物以及使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US20160326173A1
公开(公告)日：2016-11-10
申请号：US15219611
申请日：2016-07-26
发明人： Derek J. Norris , George V. Delucca , Ashvinikumar V. Gavai , Claude A. Quesnelle , Patrice Gill , Daniel O'Malley , Wayne Vaccaro , Francis Y. Lee , Mikkel V. DeBenedetto , Andrew P. Degnan , Haiquan Fang , Matthew D. Hill , Hong Huang , William D. Schmitz , John E. Starrett, JR. , Wen-Ching Han , John S. Tokarski , Sunil Kumar Mandal
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及三环化合物，包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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