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1.发明授权公开(公告)号：US11098063B2
公开(公告)日：2021-08-24
申请号：US16622233
申请日：2018-06-07
发明人： Martina Delbeck , Michael Hahn , Thomas Müller , Klemens Lustig , Karl Collins , Niels Lindner , Janine Nicolai , Moritz Beck-Broichsitter , Udo Albus , Doris Gehring , Björn Rosenstein
IPC分类号： C07D519/00 , A61P11/00
摘要： The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.
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公开(公告)号：US09688636B2
公开(公告)日：2017-06-27
申请号：US14609122
申请日：2015-01-29
发明人： Michael Hahn , Markus Follmann , Walter Hübsch , Eva-Maria Becker , Johannes-Peter Stasch , Joerg Keldenich , Martina Delbeck , Hanna Tinel , Frank Wunder , Joachim Mittendorf , Ildiko Terebesi , Dieter Lang , René Martin
IPC分类号： C07D215/48 , A61K31/4706 , C07D217/26 , C07D401/12 , C07D413/12 , A61K31/4709 , A61K45/06 , A61K31/47
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
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![N-[3-(2-carboxyethyl)phenyl]piperidin-1-ylacetamide derivatives and use thereof as activators of soluble guanylate cyclase](/abs-image/US/2016/04/12/US09309198B2/abs.jpg.150x150.jpg)
3.发明授权N-[3-(2-carboxyethyl)phenyl]piperidin-1-ylacetamide derivatives and use thereof as activators of soluble guanylate cyclase 有权N- [3-（2-羧乙基）苯基]哌啶-1-基乙酰胺衍生物及其可用作可溶性鸟苷酸环化酶的活化剂公开(公告)号：US09309198B2
公开(公告)日：2016-04-12
申请号：US14402232
申请日：2013-05-17
发明人： Thomas Lampe , Michael Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Sherif El Sheikh , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Friederike Stoll , Andreas Knorr
IPC分类号： C07D211/14 , C07D217/04 , C07D221/06 , A61K31/445 , A61K31/451 , A61K31/472 , C07D221/20 , C07D211/06 , C07D211/18 , C07D211/46 , C07D295/15 , A61K31/438 , A61K45/06
CPC分类号： C07D211/14 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/472 , A61K45/06 , C07D211/06 , C07D211/18 , C07D211/46 , C07D217/04 , C07D221/20 , C07D295/15
摘要： The present application relates to novel substituted 2-(piperidin-1-yl)acetamide derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本申请涉及新型取代的2-（哌啶-1-基）乙酰胺衍生物，其制备方法及其用于治疗和/或预防疾病的用途，以及其用于生产用于治疗和 /或预防疾病，特别是用于治疗和/或预防心血管疾病。
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4.发明申请SUBSTITUTED AMINOINDANE- AND AMINOTETRALINECARBOXYLIC ACIDS AND THE USE THEREOF 有权取代的氨基氨基和氨基甲酰氧基酸及其用途公开(公告)号：US20150174113A1
公开(公告)日：2015-06-25
申请号：US14414297
申请日：2013-07-16
发明人： Walter Hübsch , Michael Hahn , Alexandros Vakalopoulos , Volkhart Min-Jian Li , Frank Wunder , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Friederike Stoll , Niels Lindner , Eva Maria Becker-Pelster
IPC分类号： A61K31/45 , C07C227/18 , A61K31/197 , A61K45/06 , C07D211/76 , A61K31/4015 , C07D263/22 , A61K31/421 , C07D231/12 , A61K31/415 , C07C229/50 , C07D207/27
CPC分类号： A61K31/45 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/2059 , A61K31/197 , A61K31/24 , A61K31/277 , A61K31/4015 , A61K31/415 , A61K31/421 , A61K45/06 , C07C227/18 , C07C229/50 , C07C255/54 , C07C2602/08 , C07C2602/10 , C07D207/27 , C07D211/76 , C07D231/12 , C07D263/22 , A61K2300/00
摘要： The present application relates to novel substituted aminoindane- and aminotetralinecarboxylic acids, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular and cardiopulmonary diseases.
摘要翻译： 本申请涉及新型取代氨基茚满和氨基四氢萘羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管和心肺疾病。
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![2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders](/abs-image/US/2020/09/01/US10759794B2/abs.jpg.150x150.jpg)
公开(公告)号：US10759794B2
公开(公告)日：2020-09-01
申请号：US15756867
申请日：2016-12-07
发明人： Martina Delbeck , Michael Hahn , Thomas Müller , Heinrich Meier , Klemens Lustig , Johanna Mosig , Luisella Toschi , Udo Albus , Doris Gehring , Björn Rosenstein
IPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , A61P11/16
摘要： The present application relates to novel 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.
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公开(公告)号：US10053428B2
公开(公告)日：2018-08-21
申请号：US15600132
申请日：2017-05-19
发明人： Michael Hahn , Markus Follmann , Eva-Maria Becker , Johannes-Peter Stasch , Joerg Keldenich , Martina Delbeck , Hanna Tinel , Frank Wunder , Joachim Mittendorf , Ildiko Terebesi , Dieter Lang , René Martin , Walter Hübsch
IPC分类号： A61K31/4706 , C07D215/48 , C07D217/26 , C07D401/12 , C07D413/12 , A61K31/4709 , A61K45/06 , A61K31/47
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
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![N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE](/abs-image/US/2015/06/04/US20150152050A1/abs.jpg.150x150.jpg)
7.发明申请N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE 有权N- [3-（2-羧基乙基）苯基]哌啶-1-基乙酰胺衍生物及其作为可溶性葡萄糖酸环化酶的活化剂的用途公开(公告)号：US20150152050A1
公开(公告)日：2015-06-04
申请号：US14402232
申请日：2013-05-17
发明人： Thomas Lampe , Michael Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Sherif El Sheikh , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Friederike Stoll , Andreas Knorr
IPC分类号： C07D211/14 , A61K45/06 , A61K31/472 , A61K31/438 , A61K31/451 , C07D217/04 , A61K31/445 , C07D221/20
CPC分类号： C07D211/14 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/472 , A61K45/06 , C07D211/06 , C07D211/18 , C07D211/46 , C07D217/04 , C07D221/20 , C07D295/15
摘要： The present application relates to novel substituted 2-(piperidin-1-yl)acetamide derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本申请涉及新型取代的2-（哌啶-1-基）乙酰胺衍生物，其制备方法及其用于治疗和/或预防疾病的用途，以及其用于生产用于治疗和 /或预防疾病，特别是用于治疗和/或预防心血管疾病。
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8.发明授权公开(公告)号：US11208422B2
公开(公告)日：2021-12-28
申请号：US16622779
申请日：2018-06-07
发明人： Martina Delbeck , Michael Hahn , Thomas Müller , Klemens Lustig , Johanna Anlahr , Karl Collins , Janine Nicolai , Moritz Beck-Broichsitter , Udo Albus , Doris Gehring , Björn Rosenstein , Hongkai Dang , Dehe Duan , Jianfei Yang , Denghui Chen
IPC分类号： C07D519/00 , A61P11/00 , A61K45/06 , A61K31/5513 , A61P25/00
摘要： The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring. Formula (I) in which the ring Q represents a bridged 1,4-diazepane cycle.
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公开(公告)号：US08981104B2
公开(公告)日：2015-03-17
申请号：US13945675
申请日：2013-07-18
发明人： Michael Hahn , Markus Follmann , Walter Hübsch , Eva-Maria Becker , Johannes-Peter Stasch , Joerg Keldenich , Martina Delbeck , Hanna Tinel , Frank Wunder , Joachim Mittendorf , Ildiko Terebesi , Dieter Lang , René Martin
IPC分类号： C07D215/38 , C07D215/48 , C07D217/26 , C07D401/12 , C07D413/12 , A61K31/4706 , A61K31/4709 , A61K45/06
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
摘要翻译： 本申请涉及新的5-氨基-5,6,7,8-四氢喹啉-2-羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管和心肺疾病的药物。
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公开(公告)号：US20220259228A1
公开(公告)日：2022-08-18
申请号：US17447795
申请日：2021-09-15
发明人： Martina DELBECK , Michael Hahn , Thomas Müller , Klemens Lustig , Johanna Anlahr , Udo Albus , Doris Gehring , Björn Rosenstein , Karl Collins , Niels Lindner , Janine Nicolai , Moritz Beck-Broichsitter
IPC分类号： C07D519/00 , A61P11/00 , G16C20/64 , A61K9/00 , A61K9/08 , A61K31/439 , A61K31/444 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K45/06
摘要： The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1- and/or TASK-3-blocking properties.
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