公开(公告)号：US20230365418A1

公开(公告)日：2023-11-16

申请号：US18196087

申请日：2023-05-11

申请人： Board of Regents, the University of Texas System

发明人： Venu Varanasi ,  Pranesh Aswath ,  Kamal Awad ,  Marco Brotto

IPC分类号： C01B33/193 ,  A61K47/69

CPC分类号： C01B33/193 ,  A61K47/6923 ,  C01P2002/02 ,  C01P2004/64 ,  C01P2004/62 ,  C01P2004/50 ,  C01P2006/80 ,  C01P2004/03 ,  C01P2004/04 ,  C01P2002/72 ,  C01P2002/82 ,  B82Y40/00

摘要： Disclosed herein is a method comprising a) forming a mixture comprising: i) an aromatic nitrogen-containing compound, ii) a saccharide; and iii) a silica precursor; b) adding an amount of water to the mixture to initiate a condensation reaction; and c) precipitating a plurality of amorphous silica-based nanoparticles. Also disclosed herein is a plurality of amorphous silica-based nanoparticles, scaffolds, and devices comprising the same, in addition to methods of using the same.

公开(公告)号：US20210138120A1

公开(公告)日：2021-05-13

申请号：US17096390

申请日：2020-11-12

申请人： THE TEXAS A&M UNIVERSITY SYSTEM ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  UT- BATTELLE, LLC

发明人： Venu Varanasi ,  Pranesh Aswath ,  Megen Maginot ,  Nickolay V. Lavrik

IPC分类号： A61L31/08 ,  C23C16/40 ,  C23C16/30 ,  A61L31/16 ,  C23C16/02

摘要： Amorphous SiOx (SiO2), SiONx, silicon nitride (Si3N4), surface treatments are provided, on both metal (titanium) and non-metal surfaces. Amorphous silicon-film surface treatments are shown to enhance osteoblast and osteoblast progenitor cell bioactivity, including biomineral formation and osteogenic gene panel expression, as well as enhanced surface hydroxyapatite (HA) formation. A mineralized tissue interface is provided using the amorphous silicon-based surface treatments in the presence of osteoblasts, and provides improved bone cell generation/repair and improved interface for secure attachment/bonding to bone. Methods for providing PEVCD-based silicon overlays onto surfaces are provided. Methods of increasing antioxidant enzyme (e.g., superoxide dismutase) expression at a treated surface for enhanced healing are also provided. Continuous generation and release of Si4+ ion into an in vitro or in vivo environment in the presence of osteoblasts/osteoblast progenitor cells, methods of employing same for enhancing the rate of bone healing/bone regeneration, is also described.

公开(公告)号：US10828393B2

公开(公告)日：2020-11-10

申请号：US15455120

申请日：2017-03-09

申请人： The Texas A&M University System ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Venu Varanasi ,  Pranesh Aswath ,  Philip Kramer ,  Megen Velten ,  Azhar Ilyas

IPC分类号： A61L27/32 ,  A61L27/54 ,  A61L27/10 ,  A61L27/38 ,  C09D1/00 ,  C04B35/597 ,  C23C16/50 ,  C23C16/22 ,  A61C8/02 ,  A61C8/00 ,  A61F2/30 ,  C23C16/30 ,  C04B35/515 ,  C09D7/60

摘要： Disclosed are compositions, methods and processes for fabricating and using a device or other implement including a surface or surfaces having a nanoscale or microscale layer or coating of Si—O—N—P. These coatings and/or layers may be continuous, on the surface or discontinuous (e.g., patterned, grooved), and may be provided on silica surfaces, metal (e.g., titanium), ceramic, and combination/hybrid materials. Methods of producing an implantable device, such as a load-bearing or non-load-bearing device, such as a bone or other structural implant device (load-bearing), are also presented. Craniofacial, osteogenic and disordered bone regeneration (osteoporosis) uses and applications of devices that include at least one surface that is treated to include a nanoscale or microscale layer or coating of Si—O—N—P are also provided. Methods of using the treated and/or coated devices to enhance enhanced vascularization and healing at a treated surface of a device in vivo, is also presented.