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公开(公告)号：US20210138120A1
公开(公告)日：2021-05-13
申请号：US17096390
申请日：2020-11-12
申请人： THE TEXAS A&M UNIVERSITY SYSTEM , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , UT- BATTELLE, LLC
摘要： Amorphous SiOx (SiO2), SiONx, silicon nitride (Si3N4), surface treatments are provided, on both metal (titanium) and non-metal surfaces. Amorphous silicon-film surface treatments are shown to enhance osteoblast and osteoblast progenitor cell bioactivity, including biomineral formation and osteogenic gene panel expression, as well as enhanced surface hydroxyapatite (HA) formation. A mineralized tissue interface is provided using the amorphous silicon-based surface treatments in the presence of osteoblasts, and provides improved bone cell generation/repair and improved interface for secure attachment/bonding to bone. Methods for providing PEVCD-based silicon overlays onto surfaces are provided. Methods of increasing antioxidant enzyme (e.g., superoxide dismutase) expression at a treated surface for enhanced healing are also provided. Continuous generation and release of Si4+ ion into an in vitro or in vivo environment in the presence of osteoblasts/osteoblast progenitor cells, methods of employing same for enhancing the rate of bone healing/bone regeneration, is also described.
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公开(公告)号：US10828393B2
公开(公告)日：2020-11-10
申请号：US15455120
申请日：2017-03-09
发明人： Venu Varanasi , Pranesh Aswath , Philip Kramer , Megen Velten , Azhar Ilyas
IPC分类号： A61L27/32 , A61L27/54 , A61L27/10 , A61L27/38 , C09D1/00 , C04B35/597 , C23C16/50 , C23C16/22 , A61C8/02 , A61C8/00 , A61F2/30 , C23C16/30 , C04B35/515 , C09D7/60
摘要： Disclosed are compositions, methods and processes for fabricating and using a device or other implement including a surface or surfaces having a nanoscale or microscale layer or coating of Si—O—N—P. These coatings and/or layers may be continuous, on the surface or discontinuous (e.g., patterned, grooved), and may be provided on silica surfaces, metal (e.g., titanium), ceramic, and combination/hybrid materials. Methods of producing an implantable device, such as a load-bearing or non-load-bearing device, such as a bone or other structural implant device (load-bearing), are also presented. Craniofacial, osteogenic and disordered bone regeneration (osteoporosis) uses and applications of devices that include at least one surface that is treated to include a nanoscale or microscale layer or coating of Si—O—N—P are also provided. Methods of using the treated and/or coated devices to enhance enhanced vascularization and healing at a treated surface of a device in vivo, is also presented.
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公开(公告)号：US10898618B2
公开(公告)日：2021-01-26
申请号：US14848107
申请日：2015-09-08
申请人： THE TEXAS A&M UNIVERSITY SYSTEM , BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM , UT-BATTELLE, LLC
摘要： Amorphous SiOx (SiO2), SiONx, silicon nitride (Si3N4), surface treatments are provided, on both metal (titanium) and non-metal surfaces. Amorphous silicon-film surface treatments are shown to enhance osteoblast and osteoblast progenitor cell bioactivity, including biomineral formation and osteogenic gene panel expression, as well as enhanced surface hydroxyapatite (HA) formation. A mineralized tissue interface is provided using the amorphous silicon-based surface treatments in the presence of osteoblasts, and provides improved bone cell generation/repair and improved interface for secure attachment/bonding to bone. Methods for providing PEVCD-based silicon overlays onto surfaces are provided. Methods of increasing antioxidant enzyme (e.g., superoxide dismutase) expression at a treated surface for enhanced healing are also provided. Continuous generation and release of Si4+ ion into an in vitro or in vivo environment in the presence of osteoblasts/osteoblast progenitor cells, methods of employing same for enhancing the rate of bone healing/bone regeneration, is also described.
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公开(公告)号：US20230365418A1
公开(公告)日：2023-11-16
申请号：US18196087
申请日：2023-05-11
发明人： Venu Varanasi , Pranesh Aswath , Kamal Awad , Marco Brotto
IPC分类号： C01B33/193 , A61K47/69
CPC分类号： C01B33/193 , A61K47/6923 , C01P2002/02 , C01P2004/64 , C01P2004/62 , C01P2004/50 , C01P2006/80 , C01P2004/03 , C01P2004/04 , C01P2002/72 , C01P2002/82 , B82Y40/00
摘要： Disclosed herein is a method comprising a) forming a mixture comprising: i) an aromatic nitrogen-containing compound, ii) a saccharide; and iii) a silica precursor; b) adding an amount of water to the mixture to initiate a condensation reaction; and c) precipitating a plurality of amorphous silica-based nanoparticles. Also disclosed herein is a plurality of amorphous silica-based nanoparticles, scaffolds, and devices comprising the same, in addition to methods of using the same.
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公开(公告)号：US20170348459A1
公开(公告)日：2017-12-07
申请号：US15455120
申请日：2017-03-09
发明人： Venu Varanasi , Pranesh Aswath , Philip Kramer , Megen Velten , Azhar Ilyas
IPC分类号： A61L27/32 , A61C8/02 , C09D1/00 , C23C16/22 , C04B35/597 , A61F2/30 , A61L27/10 , A61L27/38 , A61L27/54 , C23C16/50 , A61C8/00
摘要： Disclosed are compositions, methods and processes for fabricating and using a device or other implement including a surface or surfaces having a nanoscale or microscale layer or coating of Si—O—N—P. These coatings and/or layers may be continuous, on the surface or discontinuous (e.g., patterned, grooved), and may be provided on silica surfaces, metal (e.g., titanium), ceramic, and combination/hybrid materials. Methods of producing an implantable device, such as a load-bearing or non-load-bearing device, such as a bone or other structural implant device (load-bearing), are also presented. Craniofacial, osteogenic and disordered bone regeneration (osteoporosis) uses and applications of devices that include at least one surface that is treated to include a nanoscale or microscale layer or coating of Si—O—N—P are also provided. Methods of using the treated and/or coated devices to enhance enhanced vascularization and healing at a treated surface of a device in vivo, is also presented.
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