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公开(公告)号：US20230227875A1
公开(公告)日：2023-07-20
申请号：US18059949
申请日：2022-11-29
申请人： Codexis, Inc.
发明人： Haibin Chen , Yong Koy Bong , Fabien L. Cabirol , Anupam Gohel Prafulchandra , Tao Li , Jeffrey C. Moore , Martina Quintanar-Audelo , Yang Hong , Steven J. Collier , Derek Smith
CPC分类号： C12P17/12 , C12P17/188 , C12N9/0071 , C12Y114/11002 , C12P13/24 , C12P13/04 , Y02P20/52
摘要： The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.
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公开(公告)号：US11549132B2
公开(公告)日：2023-01-10
申请号：US17221613
申请日：2021-04-02
申请人： Codexis, Inc.
发明人： Haibin Chen , Yong Koy Bong , Fabien L. Cabirol , Anupam Gohel Prafulchandra , Tao Li , Jeffrey C. Moore , Martina Quintanar-Audelo , Yang Hong , Steven J. Collier , Derek Smith
摘要： The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.
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公开(公告)号：US20190323046A1
公开(公告)日：2019-10-24
申请号：US16446866
申请日：2019-06-20
申请人： Codexis, Inc.
发明人： Haibin Chen , Yong Koy Bong , Fabien L. Cabirol , Anupam Gohel Prafulchandra , Tao Li , Jeffrey C. Moore , Martina Quintanar-Audelo , Yang Hong , Steven J. Collier , Derek Smith
摘要： The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.
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4.发明授权Engineered imine reductases and methods for the reductive amination of ketone and amine compounds 有权工程亚胺还原酶和酮和胺化合物的还原胺化方法公开(公告)号：US09487760B2
公开(公告)日：2016-11-08
申请号：US15048887
申请日：2016-02-19
申请人： CODEXIS, INC.
发明人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt W. Huisman , Scott J. Novick , Nicholas J. Agard , Oscar Alvizo , Gregory A. Cope , Wan Lin Yeo , Stefanie Ng Minor
IPC分类号： C12N9/06 , C12P13/00 , C12P17/18 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/16
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
摘要翻译： 本公开提供了具有亚胺还原酶活性的工程改造的多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法 产品化合物。
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5.发明授权公开(公告)号：US09296993B2
公开(公告)日：2016-03-29
申请号：US14887943
申请日：2015-10-20
申请人： Codexis, Inc.
发明人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt W. Huisman , Scott J. Novick , Nicholas J. Agard , Oscar Alvizo , Gregory A. Cope , Wan Lin Yeo , Stefanie Ng Minor
IPC分类号： C07H21/00 , C12N15/52 , C12N9/06 , C12P13/00 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/16 , C12P17/18
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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公开(公告)号：US11713451B2
公开(公告)日：2023-08-01
申请号：US17084405
申请日：2020-10-29
申请人： Codexis, Inc.
发明人： Fabien Louis Cabirol , Haibin Chen , Anupam Gohel , Steven J. Collier , Derek J. Smith , Birgit Kosjek , Jacob Janey
CPC分类号： C12N9/0006 , C12P13/00 , C12P13/001 , C12P13/02 , C12P41/002 , C12Y101/01184 , C12N15/70 , Y02P20/52
摘要： The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.
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公开(公告)号：US20200325510A1
公开(公告)日：2020-10-15
申请号：US16913761
申请日：2020-06-26
申请人： Codexis, Inc.
发明人： Haibin Chen , Yong Koy Bong , Fabien L. Cabirol , Anupam Gohel Prafulchandra , Tao Li , Jeffrey C. Moore , Martina Quintanar-Audelo , Yang Hong , Steven J. Collier , Derek Smith
摘要： The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.
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8.发明授权公开(公告)号：US10787689B2
公开(公告)日：2020-09-29
申请号：US16655547
申请日：2019-10-17
申请人： CODEXIS, INC.
发明人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt W. Huisman , Scott J. Novick , Nicholas J. Agard , Oscar Alvizo , Gregory A. Cope , Wan Lin Yeo , Stefanie Ng Minor
IPC分类号： C12N9/06 , C12P13/02 , C12P13/00 , C12P17/18 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/16
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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公开(公告)号：US10308966B2
公开(公告)日：2019-06-04
申请号：US16195480
申请日：2018-11-19
申请人： CODEXIS, INC.
发明人： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt W. Huisman , Scott J. Novick , Nicholas J. Agard , Oscar Alvizo , Gregory A. Cope , Wan Lin Yeo , Stefanie Ng Minor
IPC分类号： C12N9/06 , C12P13/00 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/16 , C12P17/18
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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公开(公告)号：US10100287B2
公开(公告)日：2018-10-16
申请号：US15711119
申请日：2017-09-21
申请人： Codexis, Inc.
发明人： Fabien Louis Cabirol , Haibin Chen , Anupam Gohel , Steven J. Collier , Derek J. Smith , Birgit Kosjek , Jacob Janey
摘要： The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.
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