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公开(公告)号：US12280368B2
公开(公告)日：2025-04-22
申请号：US17780352
申请日：2020-11-09
Applicant: CORNING INCORPORATED
Inventor： John Wilfred Coddaire , Maryanne De Chambeau , James Thomas Eickmann , Paula Mary Flaherty , Anthony Glenn Frutos , Vasiliy Nikolaevich Goral , Angela Langer Julien , Marshall Jay Kosovsky , Brent Ravaughn Lanterman , Gregory Roger Martin , Christie Leigh McCarthy , John Forrest Roush , John Shyu , Tora Ann-Beatrice Eline Sirkka , Allison Jean Tanner , Kimberly Ann Titus , Todd Michael Upton , Timothy James Wood
Abstract: A connected ecosystem for a laboratory environment comprises an electronic lab notebook, and instrumented biosafety cabinet, and one or more sensing vessels containing cell cultures. The electronic lab notebook interfaces with the instrumented biosafety cabinet to provide instructions, guidance, and monitoring of a user during the set up of the experimental protocol and to receive commands from the user via one of several input modalities. After the experimental protocol has been set up in the instrumented biosafety cabinet, cell cultures may be moved to an incubator where the connected ecosystem may provide automatic monitoring of the cultures. The automatic monitoring is provided by sensors integrated into cell culture vessels and supplemented by images of the cell cultures captured by a camera. The user may be informed of deviations from expected results detected based on the automatic monitoring.
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公开(公告)号：US12270017B2
公开(公告)日：2025-04-08
申请号：US18219266
申请日：2023-07-07
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture vessel includes a vessel body, support columns, and a stabilizer device. The vessel body defines a cell culture chamber enclosed between a bottom wall and a top wall. The support column is within the cell culture chamber and extends between the top wall and the bottom wall. The stabilizer device covers a width and length of the cell culture chamber and has a column engaging structure that is sized to slidingly engage the support column such that the stabilizer device is movable along the support column as a liquid culture medium is received in the cell culture chamber. The support column guides the stabilizer device along a length of the support column as the stabilizer device rises with rising liquid level in the cell culture chamber during a liquid culture medium filling operation.
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公开(公告)号：US20240336886A1
公开(公告)日：2024-10-10
申请号：US18292184
申请日：2022-07-29
Applicant: CORNING INCORPORATED
Inventor： Thomas Albert Cloutier , William Joseph Lacey , Ana Maria del Pilar Pardo , Allison Jean Tanner
Abstract: A baffle (130) configured to be disposed in a cell culture vessel is provided. The cell culture vessel (100) may comprise a vessel body (101) comprising a bottom wall (110) and a plurality of side walls (107) that define a cell culture chamber, the bottom wall comprising a cell culture surface (111). The baffle (130) may be configured to be disposed parallel to the cell culture surface (111) within the vessel body, the baffle comprising a first baffle crossbar (133) extending across a length of the cell culture surface; a second baffle crossbar intersecting (135) the first baffle crossbar; and a third crossbar disposed (137) at an end of the first baffle crossbar.
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公开(公告)号：US11857970B2
公开(公告)日：2024-01-02
申请号：US16628474
申请日：2018-07-13
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Gregory Roger Martin , Ana Maria del Pilar Pardo , Allison Jean Tanner
CPC classification number: B01L3/5085 , C12M23/08 , C12M23/38 , B01L2300/0858
Abstract: A cell culture vessel has a wall and cell culture surface having a plurality of microcavities for culturing cells in three-dimensional conformation, referred to as “spheroids”. The inner surface of the wall and the cell culture surface define a cell culture chamber of the vessel. The wall is attached to the cell culture surface in a way that does not provide flat surfaces on or around the cell culture surface so that the vessel provides an environment suitable for the production of a homogeneous population of three-dimensional cell clusters, or spheroids.
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公开(公告)号：US11661574B2
公开(公告)日：2023-05-30
申请号：US16630024
申请日：2018-07-13
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
CPC classification number: C12M23/12 , B01L3/50273 , C12M23/38 , C12M25/04 , B01L2200/027 , B01L2300/0864 , B01L2300/123 , B01L2400/0475
Abstract: A fluidic device for culturing cells includes a microplate and plate lid. The microplate includes multiple wells and channels, the channels extending between the wells such that the channels interconnect the wells. The plate lid releasably engages the microplate to thereby enclose the wells and the channels. The wells include a culture surface such that a cell culture medium received therein is deposited over the culture surface. At least one channel that extends between adjacent ones of the wells is spaced from the culture surfaces of the adjacent wells defining a gap between the at least one channel and the culture surfaces of the adjacent wells for collection of the cell culture medium.
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Patent Agency Ranking
公开(公告)号：US20230007854A1
公开(公告)日：2023-01-12
申请号：US17780352
申请日：2020-11-09
Applicant: CORNING INCORPORATED
Inventor： John Wilfred Coddaire , Maryanne De Chambeau , James Thomas Eickmann , Paula Mary Flaherty , Anthony Glenn Frutos , Vasiliy Nikolaevich Goral , Angela Langer Julien , Marshall Jay Kosovsky , Brent Ravaughn Lanterman , Gregory Roger Martin , Christie Leigh McCarthy , John Forrest Roush , John Shyu , Tora Ann-Beatrice Eline Sirkka , Allison Jean Tanner , Kimberly Ann Titus , Todd Michael Upton , Timothy James Wood
Abstract: A connected ecosystem for a laboratory environment comprises an electronic lab notebook, and instrumented biosafety cabinet, and one or more sensing vessels containing cell cultures. The electronic lab notebook interfaces with the instrumented biosafety cabinet to provide instructions, guidance, and monitoring of a user during the set up of the experimental protocol and to receive commands from the user via one of several input modalities. After the experimental protocol has been set up in the instrumented biosafety cabinet, cell cultures may be moved to an incubator where the connected ecosystem may provide automatic monitoring of the cultures. The automatic monitoring is provided by sensors integrated into cell culture vessels and supplemented by images of the cell cultures captured by a camera. The user may be informed of deviations from expected results detected based on the automatic monitoring.
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公开(公告)号：US20220400667A1
公开(公告)日：2022-12-22
申请号：US17896697
申请日：2022-08-26
Applicant: CORNING INCORPORATED
Inventor： John Wilfred Coddaire , William Joseph Lacey , Gregory Roger Martin , Michael Kurt Schaefer , Paul Michael Szlosek , Allison Jean Tanner
Abstract: Vial assemblies comprising a tubular body and a flexible bottom or flexible liner are described herein, wherein the flexible bottom or liner is configured to compress at least partially upon the application of force. Methods for storing and removing frozen samples from such vial assemblies are also described herein.
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公开(公告)号：US20220195366A1
公开(公告)日：2022-06-23
申请号：US17691511
申请日：2022-03-10
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture insert for use in culturing cells to promote the formation of spheroids and methods of using these spheroid-promoting cell culture inserts. The cell culture insert includes a porous membrane and one or more sidewalls that are non-adherent to cells and cause the cells in the insert to associate with each other and form spheroids.
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公开(公告)号：US20180355300A1
公开(公告)日：2018-12-13
申请号：US16054270
申请日：2018-08-03
Applicant: Corning Incorporated
Inventor： Gregory Roger MARTIN , Allison Jean Tanner
CPC classification number: C12M23/24 , C12M23/04 , C12M23/08 , C12M23/34 , C12M23/38 , C12M23/58 , C12M25/02 , C12M25/04 , C12M25/06 , C12M29/04 , C12M41/00 , C12N5/0602
Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.
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公开(公告)号：US20160186113A1
公开(公告)日：2016-06-30
申请号：US15063040
申请日：2016-03-07
Applicant: Corning Incorporated
Inventor： Allison Jean Tanner , Gregory Roger Martin
Abstract: A multilayered cell culture apparatus for the co-culturing of at least two cell types is disclosed. The cell co-culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between some cell culture chambers and the external environment. In addition, some cell culture chambers may have limited access to air creating relatively lower oxygen content cell culture chambers. The size of the apparatus, and location of an optional neck section, allows for its manipulation by standard automated assay equipment, further making the apparatus amenable to high throughput applications.
Abstract translation: 公开了用于共培养至少两种细胞类型的多层细胞培养装置。 细胞共培养装置被定义为具有与气管空间组合的多个细胞培养室的整体结构。 该装置的主体在其中赋予气体可渗透的膜与气管空间的组合，这将允许气体在一些细胞培养室和外部环境之间自由流动。 此外，一些细胞培养室可能有限制地进入空气，产生相对较低的含氧细胞培养室。 设备的尺寸和可选的颈部的位置允许其通过标准自动化测定设备的操作，进一步使得该设备适合于高通量应用。
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