公开(公告)号：US11767499B2

公开(公告)日：2023-09-26

申请号：US16628810

申请日：2018-07-13

Applicant: CORNING INCORPORATED

Inventor： Gregory Roger Martin ,  Ana Maria Del Pilar Pardo ,  Michael Kurt Schaefer ,  Allison Jean Tanner

IPC: C12M3/06 ,  B01L3/00 ,  C12M1/24 ,  C12M1/04 ,  C12M1/00

CPC classification number: C12M23/16 ,  B01L3/502715 ,  C12M23/08 ,  C12M23/24 ,  C12M29/04 ,  B01L2300/0681 ,  B01L2300/12

Abstract: A cell culture vessel (100) includes a wall including an inner surface defining a cell culture chamber of the vessel. A substrate (215) of non-porous material is positioned in the cell culture chamber between a first region of the cell culture chamber and a second region of the cell culture chamber. The substrate includes a plurality of microcavities (220), each microcavity of the plurality of microcavities includes a concave surface defining a well and an opening, the concave surface of each microcavity includes at least one aperture including a dimension less than or equal to about 15 microns defining a path from the well to the second region. A cell culture vessel including a substrate including a plurality of microcavities and a layer of porous material is also provided. Methods of culturing cells in the cell culture vessel are also provided.

公开(公告)号：US20180242572A1

公开(公告)日：2018-08-30

申请号：US15774873

申请日：2016-11-03

Applicant: Corning Incorporated

Inventor： John Wilfred Coddaire ,  William Joseph Lacey ,  Gregory Roger Martin ,  Michael Kurt Schaefer ,  Paul Michael Szlosek ,  Allison Jean Tanner

IPC: A01N1/02 ,  B01L3/00 ,  B65D83/00

CPC classification number: A01N1/0268 ,  B01L3/5082 ,  B01L3/50825 ,  B01L3/5453 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/0832 ,  B01L2300/0851 ,  B01L2300/123 ,  B01L2400/0481 ,  B65D83/0005 ,  C12M45/22

Abstract: Vial assemblies comprising a tubular body and a flexible bottom or flexible liner are described herein, wherein the flexible bottom or liner is configured to compress at least partially upon the application of force. Methods for storing and removing frozen samples from such vial assemblies are also described herein.

公开(公告)号：US11583847B2

公开(公告)日：2023-02-21

申请号：US16767349

申请日：2018-11-28

Applicant: CORNING INCORPORATED

Inventor： John Claude Cadotte, Jr. ,  Venu Krishna Pillai ,  Michael Kurt Schaefer ,  James Mark Seymour

IPC: B01L3/02 ,  B29C49/04 ,  B29C49/16 ,  B29C49/02 ,  B29C49/20 ,  B29K23/00 ,  B29K25/00 ,  B29K701/10

Abstract: Measuring pipettes including integral or encapsulated filters, as well as methods and apparatuses for forming the same, are provided. A filter material (e.g., a discrete element in solid form) or a filter material precursor (e.g., a foamable thermoplastic composition and a blowing agent) to be introduced into a hollow interior of a softened thermoplastic material present within a mold during pipette fabrication. A pipette includes a filter element comprising foamed polymeric material within a mouthpiece region, wherein an outer portion of the filter element is bound to or encapsulated in an inner wall of the mouthpiece region. A filter material precursor may be supplied coaxially with a tubular flow of thermoplastic material into the mold, may be supplied laterally through a mold wall, or may be injected into a molten thermoplastic pipette forming material upstream of an extruder outlet.

公开(公告)号：US20220400667A1

公开(公告)日：2022-12-22

申请号：US17896697

申请日：2022-08-26

Applicant: CORNING INCORPORATED

Inventor： John Wilfred Coddaire ,  William Joseph Lacey ,  Gregory Roger Martin ,  Michael Kurt Schaefer ,  Paul Michael Szlosek ,  Allison Jean Tanner

IPC: A01N1/02 ,  B65D83/00 ,  C12M1/00 ,  B01L3/00

Abstract: Vial assemblies comprising a tubular body and a flexible bottom or flexible liner are described herein, wherein the flexible bottom or liner is configured to compress at least partially upon the application of force. Methods for storing and removing frozen samples from such vial assemblies are also described herein.

公开(公告)号：US20210001325A1

公开(公告)日：2021-01-07

申请号：US16767324

申请日：2018-11-28

Applicant: CORNING INCORPORATED

Inventor： John Claude Cadotte, Jr. ,  Michael Kurt Schaefer ,  James Mark Seymour

IPC: B01L3/02 ,  B29C49/06

Abstract: A stretch blow molding method may include fabricating a preform (e.g., by molding, optionally while a core pin rotates within a mold cavity), heating the preform to a softening temperature, stretching and thereby elongating at least a portion of the heated preform, blowing the elongated preform with pressurized fluid within a mold cavity, and cooling the resulting pipette. A system for fabricating a stretch blow molded pipette includes a first mold defining a mold cavity for producing a preform. A stretch rod drive unit is configured to move a stretch rod within an interior of the preform to form an elongated preform, and a second mold defines blow molding cavity and a molding surface to contain expansion of the elongated perform when subjected to blowing by supplying pressurized fluid to an interior thereof.

公开(公告)号：US20180264460A1

公开(公告)日：2018-09-20

申请号：US15986323

申请日：2018-05-22

Applicant: Corning Incorporated

Inventor： John Claude Cadotte, JR. ,  Gregory Roger Martin ,  Michael Kurt Schaefer ,  James Mark Seymour

IPC: B01L3/02

CPC classification number: B01L3/021 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0838 ,  B01L2300/0858 ,  B01L2300/12 ,  B01L2300/16 ,  B29C49/04 ,  B29D23/001 ,  B29K2023/12 ,  B29K2025/06

Abstract: A pipette may comprise a length, a longitudinal axis, and an inner curved surface enclosing a space. The pipette may have a tip region having a tip thickness. The tip region may be connected to a body region having a body thickness. The tip thickness may be greater than the body thickness. The body region may be connected to a mouth region having a mouth thickness. The mouth thickness may be greater than the body thickness. The inner curved surface may not contain bumps or ridges either between the tip region and the body region or between the body region and the mouth region. The pipette may be formed by blow molding or vacuum forming.

公开(公告)号：US11065612B2

公开(公告)日：2021-07-20

申请号：US15986323

申请日：2018-05-22

Applicant: Corning Incorporated

Inventor： John Claude Cadotte, Jr. ,  Gregory Roger Martin ,  Michael Kurt Schaefer ,  James Mark Seymour

IPC: B01L3/02 ,  B29C49/04 ,  B29K23/00 ,  B29D23/00 ,  B29K25/00

Abstract: A pipette may comprise a length, a longitudinal axis, and an inner curved surface enclosing a space. The pipette may have a tip region having a tip thickness. The tip region may be connected to a body region having a body thickness. The tip thickness may be greater than the body thickness. The body region may be connected to a mouth region having a mouth thickness. The mouth thickness may be greater than the body thickness. The inner curved surface may not contain bumps or ridges either between the tip region and the body region or between the body region and the mouth region. The pipette may be formed by blow molding or vacuum forming.

公开(公告)号：US11013230B2

公开(公告)日：2021-05-25

申请号：US16832280

申请日：2020-03-27

Applicant: CORNING INCORPORATED

Inventor： Michael Kurt Schaefer

IPC: B29C45/00 ,  A01N1/02 ,  B29K23/00 ,  B29L31/00

Abstract: A vial is described herein that comprises a tubular body which comprises an opened end, a closed end, and a cavity, wherein the opened end is located at one end of the tubular body and the closed end is located at an opposing end of the tubular body. The tubular body further comprises a tear line located therein, wherein the tear line extends across at least a portion of one side of the tubular body, across the closed end, and across at least a portion of another side of the tubular body. In addition, the tubular body further comprises two flanges extending from the closed end, wherein the two flanges are configured to separate from one another outwardly from the tubular body and apply a force to break-open at least a portion of the tear line to open at least the closed end of the tubular body.

公开(公告)号：US20170342363A1

公开(公告)日：2017-11-30

申请号：US15492690

申请日：2017-04-20

Applicant: Corning Incorporated

Inventor： Ye Fang ,  Ann MeeJin Ferrie ,  Vasiliy Nikolaevich Goral ,  Gregory Roger Martin ,  Kaitlyn Mary Matias ,  Michael Kurt Schaefer ,  Allison Jean Tanner

IPC: C12M1/32 ,  C12M3/06 ,  C12M1/26

CPC classification number: C12M23/12 ,  C12M1/268 ,  C12M3/065 ,  C12M23/02 ,  C12M23/24

Abstract: The present disclosure relates to apparatuses, systems and methods for culturing cells. In particular, devices and methods are provided for generation and culture of 3d cell aggregates.

公开(公告)号：US20170172140A1

公开(公告)日：2017-06-22

申请号：US15380249

申请日：2016-12-15

Applicant: CORNING INCORPORATED

Inventor： Michael Kurt Schaefer

IPC: A01N1/02 ,  B29C45/00

CPC classification number: A01N1/0284 ,  A01N1/0263 ,  B29C45/0081 ,  B29K2023/12 ,  B29L2031/712

Abstract: A vial is described herein that comprises a tubular body which comprises an opened end, a closed end, and a cavity, wherein the opened end is located at one end of the tubular body and the closed end is located at an opposing end of the tubular body. The tubular body further comprises a tear line located therein, wherein the tear line extends across at least a portion of one side of the tubular body, across the closed end, and across at least a portion of another side of the tubular body. In addition, the tubular body further comprises two flanges extending from the closed end, wherein the two flanges are configured to separate from one another outwardly from the tubular body and apply a force to break-open at least a portion of the tear line to open at least the closed end of the tubular body.