公开(公告)号：US20150294076A1

公开(公告)日：2015-10-15

申请号：US14440987

申请日：2013-11-06

Applicant: Patrick TREADO ,  Shona STEWART ,  Heather KIRSCHNER ,  Ryan PRIORE ,  Alan WILSON ,  CHEMIMAGE CORPORATION

Inventor： Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

IPC: G06F19/00 ,  G06F19/24 ,  G01N21/65 ,  G01N33/49

CPC classification number: G16H50/20 ,  G01J3/1804 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/65 ,  G01N33/49 ,  G01N33/57419 ,  G16B40/00

Abstract: A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.

Abstract translation: 用于分析诸如干人血清的生物样品以确定诸如结肠直肠癌（CRC）的疾病状态的系统和方法。 使用干燥的样品可能具有增强样品组分的局部浓度和/或分割的潜力。 该方法可以包括照射生物样品的至少一个位置以产生多个相互作用的光子，收集相互作用的光子并产生代表生物样品的至少一个拉曼数据集。 系统可以包括照明源以照亮生物样品的至少一个位置并且生成至少一个多个相互作用的光子，至少一个反射镜，用于将相互作用的光子引导到检测器。 检测器可以被配置为产生代表生物样品的至少一个拉曼数据集。 该系统和方法可以利用FAST设备进行多点分析，或者可以配置为使用线扫描配置分析样本。

公开(公告)号：US20130321813A1

公开(公告)日：2013-12-05

申请号：US13905817

申请日：2013-05-30

Applicant: Chemimage Corporation

Inventor： Patrick J. Treado ,  Ryan Priore

IPC: G01J3/51

CPC classification number: G01J3/51 ,  G01J3/0224 ,  G01J3/0272 ,  G01J3/457 ,  G01J2003/1213 ,  G01N21/255 ,  G01N21/33 ,  G01N21/35 ,  G01N21/359 ,  G01N21/65 ,  G01N21/718 ,  G01N2021/6471 ,  G01N2201/0221 ,  G01N2201/067 ,  G01N2201/129

Abstract: A portable system and method for analyzing biological tissue samples and detecting analytes associated with tissue oxygenation using a conformal filter. A conformal filter, which may comprise a tunable filter, is configured to filter interacted photons conforming to a spectral shape correlated with an analyte of interest. Conformal filter configurations may be selected by consulting a modified look-up table associated with an analyte. An iterative methodology may be used to calibrate a conformal design for an analyte of interest, refine a previous conformal filter design for an analyte of interest, and/or generate a new conformal filter design for an analyte of interest.

Abstract translation: 用于分析生物组织样品并使用保形过滤器检测与组织氧合相关的分析物的便携式系统和方法。 可以包括可调滤波器的保形滤波器被配置为滤波符合与感兴趣的分析物相关的光谱形状的相互作用的光子。 可以通过咨询与分析物相关联的经修改的查找表来选择保形过滤器配置。 可以使用迭代方法来校准感兴趣分析物的共形设计，改进目标分析物的先前共形过滤器设计，和/或为感兴趣的分析物生成新的保形过滤器设计。

公开(公告)号：US20130218480A1

公开(公告)日：2013-08-22

申请号：US13764374

申请日：2013-02-11

Applicant: Chemimage Corporation

Inventor： Michael Fuhrman ,  Ryan Priore ,  Oksana Olkhovyk ,  Oksana Klueva

IPC: G01N15/02

CPC classification number: G01N15/0227 ,  G01J3/02 ,  G01J3/027 ,  G01J3/44 ,  G01N21/65

Abstract: A system and method for determining at least one geometric property of a particle in a sample. A sample is irradiated to thereby generate Raman scattered photons. These photons are collected to generate a Raman chemical image. A first threshold is applied wherein the first threshold is such that all particles in the sample are detected. A particle in the sample is selected and a second threshold is applied so that at least one geometric property of the selected particle can be determined. At least one spectrum representative of the selected particle is analyzed to determine whether or not it is a particle of interest. The step of determining a second threshold may be iterative and automated via software so that candidate second thresholds are applied until a satisfactory result is achieved.

Abstract translation: 用于确定样品中颗粒的至少一个几何性质的系统和方法。 照射样品从而产生拉曼散射光子。 收集这些光子以产生拉曼化学图像。 应用第一阈值，其中第一阈值使得检测样品中的所有颗粒。 选择样品中的颗粒并施加第二阈值，使得可以确定所选择的颗粒的至少一个几何性质。 分析代表所选粒子的至少一个光谱，以确定其是否是感兴趣的粒子。 确定第二阈值的步骤可以是经由软件的迭代和自动化，使得应用候选的第二阈值直到达到令人满意的结果。

公开(公告)号：US11145411B2

公开(公告)日：2021-10-12

申请号：US14440987

申请日：2013-11-06

Applicant: CHEMIMAGE CORPORATION ,  Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

Inventor： Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

IPC: G01N21/65 ,  G01N33/49 ,  G16H50/20 ,  G16B40/00 ,  G01N33/574 ,  G01J3/44 ,  G01J3/18

Abstract: A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.

公开(公告)号：US09274046B2

公开(公告)日：2016-03-01

申请号：US13998776

申请日：2013-12-03

Applicant: ChemImage Corporation

Inventor： Shona Stewart ,  Patrick Treado ,  Heather Kirschner ,  Alan Wilson ,  Ryan Priore ,  Jeffrey Cohen ,  Serena Augustine

IPC: G01J3/28 ,  G01N21/25 ,  G01J3/02 ,  G01J3/32 ,  G01J3/44 ,  G01N21/31 ,  G01N21/35 ,  G02B21/00 ,  G02B21/16 ,  G02B21/36 ,  G01N21/21 ,  G01N21/33 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65

CPC classification number: G01N21/255 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/32 ,  G01J3/44 ,  G01N21/21 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G02B21/0092 ,  G02B21/16 ,  G02B21/361

Abstract: A method for analyzing organ samples using hyperspectral imaging comprising illuminating an organ sample to generate interacted photons, collecting the interacted photons and passing the interacted photons through a tunable filter. The filtered interacted photons are detected to generate a hyperspectral image. A brightfield image is generated and associated with the hyperspectral image. Spectra from locations of interest are extracted and analyzed to assess a characteristic of the organ sample. A system may comprise an illumination source to illuminate an organ sample and generate interacted photons, a collection optics for collecting the interacted photons and a tunable filter to filter the interacted photons. A detector is configured to detect the filtered photons and generate at least one hyperspectral image. The detector may also be configured to generate at least one brightfield image representative of the organ sample.

Abstract translation: 一种使用高光谱成像分析器官样品的方法，包括照亮器官样品以产生相互作用的光子，收集相互作用的光子并使相互作用的光子通过可调滤光器。 检测过滤的相互作用的光子以产生高光谱图像。 生成亮场图像并与高光谱图像相关联。 提取并分析来自感兴趣位置的光谱，以评估器官样品的特征。 系统可以包括用于照亮器官样本并产生相互作用的光子的照明源，用于收集相互作用的光子的收集光学器件和用于过滤相互作用的光子的可调滤波器。 检测器被配置为检测滤波的光子并产生至少一个高光谱图像。 检测器还可以被配置为产生代表器官样本的至少一个亮场图像。