公开(公告)号：US11145411B2

公开(公告)日：2021-10-12

申请号：US14440987

申请日：2013-11-06

Applicant: CHEMIMAGE CORPORATION ,  Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

Inventor： Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

IPC: G01N21/65 ,  G01N33/49 ,  G16H50/20 ,  G16B40/00 ,  G01N33/574 ,  G01J3/44 ,  G01J3/18

Abstract: A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.

公开(公告)号：US08374801B2

公开(公告)日：2013-02-12

申请号：US12684495

申请日：2010-01-08

Applicant: Michael Fuhrman ,  Ryan Priore ,  Oksana Olkhovyk ,  Oksana Klueva

Inventor： Michael Fuhrman ,  Ryan Priore ,  Oksana Olkhovyk ,  Oksana Klueva

IPC: G01N31/00

CPC classification number: G01N15/0227 ,  G01J3/02 ,  G01J3/027 ,  G01J3/44 ,  G01N21/65

Abstract: A system and method for determining at least one geometric property of a particle in a sample. A sample is irradiated to thereby generate Raman scattered photons. These photons are collected to generate a Raman chemical image. A first threshold is applied wherein the first threshold is such that all particles in the sample are detected. A particle in the sample is selected and a second threshold is applied so that at least one geometric property of the selected particle can be determined. At least one spectrum representative of the selected particle is analyzed to determine whether or not it is a particle of interest. The step of determining a second threshold may be iterative and automated via software so that candidate second thresholds are applied until a satisfactory result is achieved.

Abstract translation: 用于确定样品中颗粒的至少一个几何性质的系统和方法。 照射样品从而产生拉曼散射光子。 收集这些光子以产生拉曼化学图像。 应用第一阈值，其中第一阈值使得检测样品中的所有颗粒。 选择样品中的颗粒并施加第二阈值，使得可以确定所选择的颗粒的至少一个几何性质。 分析代表所选粒子的至少一个光谱，以确定其是否是感兴趣的粒子。 确定第二阈值的步骤可以是经由软件的迭代和自动化，使得应用候选的第二阈值直到达到令人满意的结果。

公开(公告)号：US20100328669A1

公开(公告)日：2010-12-30

申请号：US12530267

申请日：2008-03-27

Applicant: Michael L. Myrick ,  Robert P. Freese ,  John Blackburn ,  David L. Perkins ,  Leonard Zheleznyak ,  Ryan Priore

Inventor： Michael L. Myrick ,  Robert P. Freese ,  John Blackburn ,  David L. Perkins ,  Leonard Zheleznyak ,  Ryan Priore

IPC: G01N21/00

CPC classification number: G01N21/25 ,  G01N21/31 ,  G01N21/9508 ,  G01N2201/1293

Abstract: The present subject matter relates to multivariate optical analysis systems employ multivariate optical elements and utilize multivariate optical computing methods to determine information about a product carried by light reflected from or transmitted through the product. An exemplary method of processing and monitoring the product includes introducing the product at an inspection point; illuminating the product with a spectral-specific light though an optic lens; directing the light that has passed through at least a section of the product through at least one multivariate optical element to produce a first signal, the directed light carrying information about the product; detecting the signal at a detector; and determining at least one property of the product based upon the detector output.

Abstract translation: 本主题涉及采用多变量光学元件的多变量光学分析系统，并且利用多变量光学计算方法来确定关于从产品反射或透过产品运送的光携带的产品的信息。 处理和监测产品的示例性方法包括在检查点引入产品; 通过光学透镜照射具有光谱特定光的产品; 将通过至少一部分产品的光引导通过至少一个多变量光学元件以产生第一信号，所述导光携带关于产品的信息; 在检测器处检测信号; 以及基于所述检测器输出来确定所述产品的至少一个属性。

公开(公告)号：US20130003044A1

公开(公告)日：2013-01-03

申请号：US13541171

申请日：2012-07-03

Applicant: John Maier ,  Jeffrey Cohen ,  Ryan Priore

Inventor： John Maier ,  Jeffrey Cohen ,  Ryan Priore

IPC: G01J3/28 ,  G01J3/44

CPC classification number: G01N21/84 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0248 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/4406 ,  G01J5/0846 ,  G01J2005/0077 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/129 ,  G02B21/0092 ,  G02B21/14 ,  G02B21/16

Abstract: The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte.

Abstract translation: 本公开提供了用于评估生物样品（例如体液）到感兴趣分析物的慢性暴露的系统和方法。 可以照射生物样品，从而产生一个或多个相互作用的光子。 可以检测这些相互作用的光子，从而生成代表生物样品的一个或多个光谱数据集。 可以将生成的光谱数据集与至少一个参考数据集进行比较。 每个参考数据集可以与已知分析物的已知暴露相关联。 本公开内容考虑到本文公开的系统和方法可用于分析生物样品随时间的至少一种分析物的暴露。 可以以不同的时间间隔获得数据集，以评估作为慢性暴露于分析物的结果的分子组成的变化。

公开(公告)号：US20120057743A1

公开(公告)日：2012-03-08

申请号：US13317333

申请日：2011-10-14

Applicant: Ryan Priore ,  Oksana Olkhovyk ,  Michael Fuhrman

Inventor： Ryan Priore ,  Oksana Olkhovyk ,  Michael Fuhrman

IPC: G06K9/00

CPC classification number: G01J3/02 ,  G01J3/027 ,  G01J3/44 ,  G01N15/00 ,  G01N15/1463 ,  G01N21/6456 ,  G01N21/65 ,  G01N2015/1493 ,  G01N2015/1497

Abstract: The present disclosure provides for a system and method for rapid, accurate, and reliable targeting and interrogation of pharmaceutical samples. An autofluorescence image of a sample may be generated and analyzed to identify areas of interest that exhibit autofluorescence characteristic of APIs. These areas of interest may then be targeted for analysis using Raman chemical imaging. This Raman chemical image may be used to determine geometric properties of particles present in a sample such as size and particle distribution.

Abstract translation: 本公开提供了用于药物样品的快速，准确和可靠的靶向和询问的系统和方法。 可以生成样品的自发荧光图像并进行分析，以鉴定显示API的自发荧光特征的感兴趣区域。 然后可以将这些感兴趣的区域用于使用拉曼化学成像进行分析。 该拉曼化学图像可用于确定样品中存在的颗粒的几何性质，例如尺寸和颗粒分布。

公开(公告)号：US08098373B2

公开(公告)日：2012-01-17

申请号：US12759082

申请日：2010-04-13

Applicant: Matthew Nelson ,  Patrick Treado ,  Ryan Priore

Inventor： Matthew Nelson ,  Patrick Treado ,  Ryan Priore

IPC: G01J3/28

CPC classification number: G01J3/36 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/2823 ,  G01N21/31 ,  G01N2201/0833 ,  G01N2201/0846

Abstract: System and method for spatially and spectrally parallelized FAST. A sample is illuminated to thereby produce interacted photons. The photons are passed through a filter and received at a two-dimensional end of a FAST device wherein said FAST device comprises a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack so as to effectively convert a two-dimensional array of optical fibers into a curvilinear field of view, and wherein said two-dimensional array of optical fibers is configured to receive said photons and transfer said photons out of said fiber array spectral translator device and to a spectrograph through said one-dimensional fiber stack wherein said one-dimensional fiber stack comprises at least two columns of fibers spatially offset in parallel at the entrance slit of said spectrograph. The photons are then detected at a detector to thereby obtain a spectroscopic data set representative of the sample.

Abstract translation: 用于空间和光谱平行化FAST的系统和方法。 照射样品从而产生相互作用的光子。 光子通过过滤器并在FAST装置的二维端接收，其中所述FAST装置包括被拉入一维纤维堆叠的二维光纤阵列，以有效地将二维阵列 的光纤变成曲线视场，并且其中所述二维光纤阵列被配置为接收所述光子并将所述光子从所述光纤阵列光谱转换器装置传送到通过所述一维光纤堆的光谱仪，其中 所述一维纤维堆叠包括在所述光谱仪的入口狭缝处空间上平行偏移的至少两列纤维。 然后在检测器处检测光子，从而获得代表样品的光谱数据集。

公开(公告)号：US20120229796A1

公开(公告)日：2012-09-13

申请号：US12932957

申请日：2011-03-10

Applicant: Ryan Priore

Inventor： Ryan Priore

IPC: G01J3/44 ,  G01J5/00 ,  G01J5/10

CPC classification number: G01N21/359 ,  G01N21/3563 ,  G01N21/65

Abstract: A system and method for detecting a contaminant in a sample. The contaminant may comprise melamine or a derivative thereof and the sample may comprise a feed material. The method may comprise illuminating a sample to thereby generate a first plurality of interacted photons, collecting the interacted photons, passing the interacted photons through a tunable filter, and detecting the interacted photons to generate a near infrared data set representative of the sample. This near infrared sample may comprise a hyperspectral near infrared image. The method may further comprise fusing said near infrared data set with a Raman data set representative of sample. A system may comprise an illumination source, one or more collection optics, a tunable filter, and a detector configured to generate a near infrared data set. The system may further comprise a second detector configured for generating a Raman data set representative of a sample.

Abstract translation: 用于检测样品中污染物的系统和方法。 污染物可以包括三聚氰胺或其衍生物，并且样品可以包含进料。 该方法可以包括照亮样品从而产生第一多个相互作用的光子，收集相互作用的光子，使相互作用的光子通过可调谐滤光器，以及检测相互作用的光子以产生代表样品的近红外数据集。 该近红外样品可以包括高光谱近红外图像。 该方法还可以包括将所述近红外数据集与表示样本的拉曼数据集进行融合。 系统可以包括照明源，一个或多个收集光学器件，可调谐滤波器和被配置为生成近红外数据集的检测器。 该系统还可以包括被配置用于生成表示样本的拉曼数据集的第二检测器。

公开(公告)号：US08993964B2

公开(公告)日：2015-03-31

申请号：US12932957

申请日：2011-03-10

Applicant: Ryan Priore

Inventor： Ryan Priore

IPC: G01J5/00 ,  G01N21/359 ,  G01N21/65 ,  G01N21/3563

CPC classification number: G01N21/359 ,  G01N21/3563 ,  G01N21/65

Abstract: A system and method for detecting a contaminant in a sample. The contaminant may comprise melamine or a derivative thereof and the sample may comprise a feed material. The method may comprise illuminating a sample to thereby generate a first plurality of interacted photons, collecting the interacted photons, passing the interacted photons through a tunable filter, and detecting the interacted photons to generate a near infrared data set representative of the sample. This near infrared sample may comprise a hyperspectral near infrared image. The method may further comprise fusing said near infrared data set with a Raman data set representative of sample. A system may comprise an illumination source, one or more collection optics, a tunable filter, and a detector configured to generate a near infrared data set. The system may further comprise a second detector configured for generating a Raman data set representative of a sample.

Abstract translation: 用于检测样品中污染物的系统和方法。 污染物可以包括三聚氰胺或其衍生物，并且样品可以包含进料。 该方法可以包括照亮样品从而产生第一多个相互作用的光子，收集相互作用的光子，使相互作用的光子通过可调谐滤光器，以及检测相互作用的光子以产生代表样品的近红外数据集。 该近红外样品可以包括高光谱近红外图像。 该方法还可以包括将所述近红外数据集与表示样本的拉曼数据集进行融合。 系统可以包括照明源，一个或多个收集光学器件，可调谐滤波器和被配置为生成近红外数据集的检测器。 该系统还可以包括被配置用于生成表示样本的拉曼数据集的第二检测器。

公开(公告)号：US20130027701A1

公开(公告)日：2013-01-31

申请号：US13347788

申请日：2012-01-11

Applicant: Ryan Priore ,  John Maier

Inventor： Ryan Priore ,  John Maier

IPC: G01J3/28 ,  G02B5/20 ,  G01J3/45

CPC classification number: G01J3/02 ,  G01J3/0297 ,  G01J3/28 ,  G01J3/44 ,  G01J2003/1213 ,  G01N21/276 ,  G01N21/65 ,  G01N2201/1293

Abstract: The present disclosure provides for a correction filter that may be configured to comprise a predetermined arrangement of thin film layers. This arrangement of thin film layers may be such that it effectively enables a correction filter to generate a predetermined spectral response, wherein said predetermined spectral response is substantially the same as a determined instrument response correction associated with an instrument. The invention of the present disclosure therefore provides for effectively compensating for transmission inefficiencies associated with an instrument without the need for separate reference measurements to determine and correct for instrument response.

Abstract translation: 本公开提供了一种校正滤波器，其可被配置为包括薄膜层的预定排列。 薄膜层的这种布置可以使得其有效地使得校正滤波器能够产生预定的光谱响应，其中所述预定光谱响应与与仪器相关联的确定的仪器响应校正基本相同。 因此，本公开的发明提供了有效地补偿与仪器相关联的传输效率低下，而不需要单独的参考测量来确定和校正仪器响应。

公开(公告)号：US20120133775A1

公开(公告)日：2012-05-31

申请号：US13020997

申请日：2011-02-04

Applicant: Patrick Treado ,  Charles W. Gardner, JR. ,  Matthew Nelson ,  Ryan Priore

Inventor： Patrick Treado ,  Charles W. Gardner, JR. ,  Matthew Nelson ,  Ryan Priore

IPC: H01L27/146 ,  H04N5/33

CPC classification number: G01J3/32 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/0289 ,  G01J3/36 ,  G01J3/4338 ,  G01J3/44 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N33/0057

Abstract: A system and method for hyperspectral imaging to detect hazardous agents including explosive agents. A system comprising a tunable laser, a collection optics, and one or more hyperspectral imaging detectors configured for hyperspectral imaging of a target comprising an unknown material. A method comprising illuminating a target comprising an unknown material via a tunable laser to thereby generate a plurality of interacted photons. Detecting said interacted photons to generate at least one hyperspectral image representative of the target. One or more hyperspectral images may be obtained including SWIR, MWIR, and LWIR hyperspectral images. Algorithms and chemometric techniques may be applied to assess the hyperspectral images to identify the unknown material as comprising an explosive agent or a non-explosive agent. A video imaging device may also be configured to provide a video image of an area of interest, which may be assessed to identify a target for interrogation using hyperspectral imaging.

Abstract translation: 用于高光谱成像检测危险物质（包括爆炸物）的系统和方法。 一种包括可调激光器，收集光学器件和一个或多个高光谱成像检测器的系统，其被配置用于包含未知材料的靶的超光谱成像。 一种方法，包括通过可调激光照射包括未知材料的靶，从而产生多个相互作用的光子。 检测所述相互作用的光子以产生代表目标的至少一个高光谱图像。 可以获得一个或多个高光谱图像，包括SWIR，MWIR和LWIR高光谱图像。 可以应用算法和化学计量技术来评估高光谱图像以将未知材料识别为包括爆炸剂或非爆炸剂。 视频成像装置还可以被配置为提供感兴趣区域的视频图像，其可以被评估以使用高光谱成像识别用于询问的目标。