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公开(公告)号：US20130090238A1
公开(公告)日：2013-04-11
申请号：US13702913
申请日：2011-06-22
申请人： Christopher Molloy , Peter James Hayward , Paul Garry Lobb , George William Mason , Stephen Millward , Wallace James Rae , André Frederik Siraa
发明人： Christopher Molloy , Peter James Hayward , Paul Garry Lobb , George William Mason , Stephen Millward , Wallace James Rae , André Frederik Siraa
IPC分类号： A01N43/653
CPC分类号： A01N43/653 , A01N2300/00
摘要： Described is a broad spectrum, synergistic fungicidal composition when used for the preservation of a glued wood product comprising as active ingredients:(A) triadimefon, and(B) cyproconazolecharacterised in that the weight ratio of (A):(B) is from about 20:1 to about 1:1, the composition being further characterised in that the application rate for the composition is from about 10 gai/m3 to about 6,000 gai/m3
摘要翻译： 描述了当用于保存包含作为活性成分的胶木产品时的广谱协同杀真菌组合物：（A）三唑酮和（B）环唑啉，其特征在于（A）:( B）的重量比来自 约20:1至约1:1，该组合物的进一步特征在于组合物的施用量为约10gai / m 3至约6,000gai / m 3
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公开(公告)号：US09439429B2
公开(公告)日：2016-09-13
申请号：US13702913
申请日：2011-06-22
申请人： Christopher Molloy , Peter James Hayward , Paul Garry Lobb , George William Mason , Stephen Millward , Wallace James Rae , André Frederik Siraa
发明人： Christopher Molloy , Peter James Hayward , Paul Garry Lobb , George William Mason , Stephen Millward , Wallace James Rae , André Frederik Siraa
IPC分类号： A01N43/653
CPC分类号： A01N43/653 , A01N2300/00
摘要： Described is a broad spectrum, synergistic fungicidal composition when used for the preservation of a glued wood product comprising as active ingredients: (A) triadimefon, and (B) cyproconazole characterized in that the weight ratio of (A):(B) is from about 20:1 to about 1:1, the composition being further characterized in that the application rate for the composition is from about 10 gai/m3 to about 6,000 gai/m3.
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公开(公告)号：US20120003491A1
公开(公告)日：2012-01-05
申请号：US13256298
申请日：2010-03-25
CPC分类号： A01N51/00 , A01N43/36 , A01N43/40 , A01N47/02 , A01N47/38 , A01N47/40 , Y10T428/31971 , Y10T428/31986 , Y10T428/31989
摘要： A composition for surface treatment of timber and wood products that provides protection against insect damage to all surfaces without any need for a secondary insecticide treatment of one or more new, untreated surfaces generated by post-treatment processing operations including sawing, cutting, drilling, beveling, planing, sanding and/or a combination thereof, comprising one or more non-repellent insecticides.
摘要翻译： 用于表面处理木材和木材产品的组合物，其提供对所有表面的昆虫损伤的保护，而不需要对通过后处理加工操作产生的一个或多个新的未处理的表面进行二次杀虫剂处理，包括锯切，切割，钻孔，斜面 ，刨削，打磨和/或其组合，包括一种或多种不含防腐剂的杀虫剂。
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公开(公告)号：US08329310B2
公开(公告)日：2012-12-11
申请号：US13256298
申请日：2010-03-25
IPC分类号： B32B23/04
CPC分类号： A01N51/00 , A01N43/36 , A01N43/40 , A01N47/02 , A01N47/38 , A01N47/40 , Y10T428/31971 , Y10T428/31986 , Y10T428/31989
摘要： A composition for surface treatment of timber and wood products that provides protection against insect damage to all surfaces without any need for a secondary insecticide treatment of one or more new, untreated surfaces generated by post-treatment processing operations including sawing, cutting, drilling, bevelling, planing, sanding and/or a combination thereof, comprising one or more non-repellent insecticides.
摘要翻译： 用于表面处理木材和木材产品的组合物，其提供对所有表面的昆虫损伤的保护，而不需要对通过后处理加工操作产生的一个或多个新的未处理的表面进行二次杀虫剂处理，包括锯切，切割，钻孔，斜切 ，刨削，打磨和/或其组合，包括一种或多种不含防腐剂的杀虫剂。
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公开(公告)号：US20100068543A1
公开(公告)日：2010-03-18
申请号：US12517150
申请日：2007-12-04
CPC分类号： C08H8/00 , B27K3/156 , C08K5/0025 , C08L33/02 , Y10T428/31895 , Y10T428/31971 , Y10T428/31989
摘要： A composition for modification of wood products is disclosed. The composition contains a prepolymer formed by the reaction of a polyfunctional hydrophilic polymer of high molecular weight and a crosslinking agent. The composition may also contain a prepolymer formed by the reaction of a sugar and a crosslinking agent. Modification of the wood product may result in one or more of: improved stiffness, strength, surface hardness, dimensional stability, water resistance, flame retardancy, and biological resistance.
摘要翻译： 公开了一种用于木制品改性的组合物。 该组合物含有通过高分子量多官能亲水性聚合物与交联剂的反应形成的预聚物。 组合物还可以含有通过糖和交联剂的反应形成的预聚物。 木制品的改性可以产生以下一个或多个：改进的刚度，强度，表面硬度，尺寸稳定性，耐水性，阻燃性和生物抗性。
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公开(公告)号：US08252426B2
公开(公告)日：2012-08-28
申请号：US12517150
申请日：2007-12-04
IPC分类号： B03B23/04
CPC分类号： C08H8/00 , B27K3/156 , C08K5/0025 , C08L33/02 , Y10T428/31895 , Y10T428/31971 , Y10T428/31989
摘要： A composition for modification of wood products is disclosed. The composition contains a prepolymer formed by the reaction of a polyfunctional hydrophilic polymer of high molecular weight and a crosslinking agent. The composition may also contain a prepolymer formed by the reaction of a sugar and a crosslinking agent. Modification of the wood product may result in one or more of: improved stiffness, strength, surface hardness, dimensional stability, water resistance, flame retardancy, and biological resistance.
摘要翻译： 公开了一种用于木制品改性的组合物。 该组合物含有通过高分子量多官能亲水性聚合物与交联剂的反应形成的预聚物。 组合物还可以含有通过糖和交联剂的反应形成的预聚物。 木制品的改性可以产生以下一个或多个：改进的刚度，强度，表面硬度，尺寸稳定性，耐水性，阻燃性和生物抗性。
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公开(公告)号：US20100190726A1
公开(公告)日：2010-07-29
申请号：US12642877
申请日：2009-12-21
CPC分类号： A61K36/47
摘要： A method is described for producing an extract of Phyllanthus comprising the steps of: (a) extracting Phyllanthus components with a solvent; (b) fractionating the extract obtained in the preceding step on the basis of hydrophobicity; (c) collecting and combining fractions that correspond in hydrophobicity to elute fractions resulting from 10-50% methanol elution steps, wherein the elute fractions are obtained by low pressure vacuum liquid chromatography (VLC) using a C18 reversed-phase lipophilic column and a water/methanol gradient system, wherein the gradient system is based on an initial elution step of loading the column with 100% water, on intermediate elution steps with gradually decreasing water content and on a terminal elution step loading the column with 100% methanol; and (d) optionally drying the extract obtained in step (c). The invention also relates to an extract of Phyllanthus obtainable or obtained by the method or a fraction thereof and a Phyllanthus extract or fraction thereof comprising repandusinic acid, wherein the repandusinic acid is present at a concentration of at least 42 mg/g.
摘要翻译： 描述了用于生产叶酸提取物的方法，包括以下步骤：（a）用溶剂萃取叶酸成分; （b）基于疏水性对前述步骤中获得的提取物进行分级; （c）将从疏水性对应的级分与从10-50％甲醇洗脱步骤得到的洗脱级分进行收集并合并，其中洗脱级分通过使用C18反相亲油柱和水的低压真空液相色谱（VLC）获得 /甲醇梯度系统，其中梯度系统基于在具有逐渐降低的水含量的中间洗脱步骤的情况下以100％水加载柱的初始洗脱步骤，以及在100％甲醇下加载柱的末端洗脱步骤; 和（d）任选地干燥步骤（c）中获得的提取物。 本发明还涉及通过该方法或其一部分获得或获得的珍珠提取物，以及含有还原性酸的叶酸提取物或其级分，其中所述还原性酸以至少42mg / g的浓度存在。
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公开(公告)号：US20060100201A1
公开(公告)日：2006-05-11
申请号：US11255043
申请日：2005-10-20
申请人： Carl Illig , Shelley Ballentine , Jinsheng Chen , Sanath Meegalla , M. Jonathan Rudolph , Mark Wall , Kenneth Wilson , Renee DesJarlais , Carl Manthey , Christopher Flores , Christopher Molloy
发明人： Carl Illig , Shelley Ballentine , Jinsheng Chen , Sanath Meegalla , M. Jonathan Rudolph , Mark Wall , Kenneth Wilson , Renee DesJarlais , Carl Manthey , Christopher Flores , Christopher Molloy
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , C07D417/14 , C07D413/14 , C07D405/14
CPC分类号： C07D263/34 , C07D207/34 , C07D233/90 , C07D307/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The invention relates to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.
摘要翻译： 本发明涉及式I化合物：其中A，X，R 2和W在本说明书中列出，以及其抑制蛋白酪氨酸的溶剂合物，水合物，互变异构体和药学上可接受的盐 激酶，特别是c-fms激酶。 治疗自身免疫性疾病的方法 和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，结肠癌，胃癌，毛细胞白血病和非小细胞肺癌的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 还提供了骨质疏松症，佩吉特氏病和其它骨吸收介导包括关节炎，假体失败，溶骨性骨肉瘤，骨髓瘤以及与式I化合物对骨的肿瘤转移的其它疾病。
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公开(公告)号：US20140038168A1
公开(公告)日：2014-02-06
申请号：US13881835
申请日：2011-10-27
申请人： Andrey Vinnik , Peter Fedichev , Maxim Kholin , Christopher Molloy , Aron Katz
发明人： Andrey Vinnik , Peter Fedichev , Maxim Kholin , Christopher Molloy , Aron Katz
IPC分类号： C12N7/00 , C07C237/40 , C07K14/005 , G06F19/16
CPC分类号： G01N33/566 , A61K31/00 , C07C231/12 , C07C237/40 , C07C237/42 , C07C2601/14 , C07K14/005 , C07K16/1063 , C07K2317/14 , C12N7/00 , C12Q1/703 , C40B30/02 , G01N33/50 , G01N2333/162 , G01N2333/70514 , G01N2500/00 , G01N2500/02 , G06F19/16 , G06F19/706
摘要： The present invention relates to a method of designing an inhibitor of the binding of HIV (human immunodeficiency virus) glycoprotein (gp)120 to a CD4-receptor or to the integrin alpha4 beta7 (a4b7). The inhibitor interacts with at least two amino acid residues comprised in six motifs within the 3-dimensional structure of gp120. Also provided are compounds, pharmaceutical compositions thereof and uses thereof in the development of an inhibitor of the binding of a HIV gp120 to a CD4-receptor or an integrin alpha4 beta7 (a4b7). The inhibitors are useful for the prevention or treatment of an HIV infection and/or diseases associated with an HIV infection.
摘要翻译： 本发明涉及一种设计HIV（人类免疫缺陷病毒）糖蛋白（gp）120与CD4受体或整联蛋白α4β7（a4b7）结合的抑制剂的方法。 抑制剂与gp120的三维结构内的六个基序中包含的至少两个氨基酸残基相互作用。 还提供了化合物，其药物组合物及其在开发HIV gp120与CD4受体或整联蛋白α4β7（a4b7）结合的抑制剂中的用途。 抑制剂可用于预防或治疗HIV感染和/或与HIV感染相关的疾病。
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公开(公告)号：US09422527B2
公开(公告)日：2016-08-23
申请号：US13881835
申请日：2011-10-27
申请人： Andrey Vinnik , Peter Fedichev , Maxim Kholin , Christopher Molloy , Aron Katz
发明人： Andrey Vinnik , Peter Fedichev , Maxim Kholin , Christopher Molloy , Aron Katz
IPC分类号： C12N7/00 , A61K31/00 , C12Q1/70 , C40B30/02 , G01N33/50 , G06F19/16 , G06F19/00 , C07C237/40 , C07K14/005 , C07K16/10
CPC分类号： G01N33/566 , A61K31/00 , C07C231/12 , C07C237/40 , C07C237/42 , C07C2601/14 , C07K14/005 , C07K16/1063 , C07K2317/14 , C12N7/00 , C12Q1/703 , C40B30/02 , G01N33/50 , G01N2333/162 , G01N2333/70514 , G01N2500/00 , G01N2500/02 , G06F19/16 , G06F19/706
摘要： The present invention relates to a method of designing an inhibitor of the binding of HIV (human immunodeficiency virus) glycoprotein (gp)120 to a CD4-receptor or to the integrin alpha4 beta7 (a4b7). The inhibitor interacts with at least two amino acid residues comprised in six motifs within the 3-dimensional structure of gp120. Also provided are compounds, pharmaceutical compositions thereof and uses thereof in the development of an inhibitor of the binding of a HIV gp120 to a CD4-receptor or an integrin alpha4 beta7 (a4b7). The inhibitors are useful for the prevention or treatment of an HIV infection and/or diseases associated with an HIV infection.
摘要翻译： 本发明涉及一种设计HIV（人类免疫缺陷病毒）糖蛋白（gp）120与CD4受体或整联蛋白α4β7（a4b7）结合的抑制剂的方法。 抑制剂与gp120的三维结构内的六个基序中包含的至少两个氨基酸残基相互作用。 还提供了化合物，其药物组合物及其在开发HIV gp120与CD4受体或整联蛋白α4β7（a4b7）结合的抑制剂中的用途。 抑制剂可用于预防或治疗HIV感染和/或与HIV感染相关的疾病。
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