公开(公告)号：US20180193485A1

公开(公告)日：2018-07-12

申请号：US15915166

申请日：2018-03-08

申请人： City University of Hong Kong

发明人： Mengsu YANG ,  Dandan LIU

IPC分类号： A61K47/69 ,  A61P35/00 ,  A61K47/68 ,  A61K49/00 ,  C07K16/28 ,  A61K41/00 ,  A61K9/00 ,  C07K16/30 ,  A61K39/395 ,  A61N2/00

CPC分类号： A61K47/6925 ,  A61K9/0019 ,  A61K39/3955 ,  A61K39/39558 ,  A61K41/0052 ,  A61K47/6849 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/0019 ,  A61K49/0045 ,  A61K49/0058 ,  A61K49/0093 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  A61N2/002 ,  A61P35/00 ,  C07K16/2887 ,  C07K16/30

摘要： There is disclosed a composition in the form of a nanoparticle. The nanoparticle composition has a diameter from 5 to 500 nanometers. The nanoparticle composition has i) a central core portion including magnetic Fe3O4 nanoparticles adapted to act as a heat source when subjected to a magnetic field and a chemotherapeutic agent configured to treat cancer tissues, ii)—a shell portion including a shell member encapsulating said core portion, and iii)—antibodies configured to target cancer stem cells and adhered to surface of said shell member. The chemotherapeutic agent is a heat shock protein inhibitor and is releasable on activation of the heat source due to the magnetic field, and the shell member is made of silica or a silica based material. Surface of the nanoparticle is modified with the antibodies capable of binding with a cluster of differentiation molecules on the cell surface of the target cancer stem cells, whereby by way of combination of specificity of the nanoparticle composition due to the antibody, thermo-therapeutic effect of the Fe3O4 nanoparticles, and release of the heat shock protein inhibitor on site at the target cancer stem cells, inhibition of the target cancer stem cells is synergistically and additionally enhanced is increased.

公开(公告)号：US20160367671A1

公开(公告)日：2016-12-22

申请号：US14745639

申请日：2015-06-22

申请人： City University of Hong Kong

发明人： Mengsu YANG ,  Dandan LIU

IPC分类号： A61K41/00 ,  A61K39/395 ,  A61K39/44 ,  A61K31/395 ,  A61K49/00 ,  A61K9/51

CPC分类号： A61K41/0052 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/5115 ,  A61K31/395 ,  A61K39/39558 ,  A61K41/00 ,  A61K41/0028 ,  A61K47/50 ,  A61K49/0093 ,  A61K2039/505 ,  C07K16/2887 ,  C07K2317/77

摘要： There is provided a nanoparticle composition comprising a central core portion including magnetic nanoparticles adapted to act as a heat source and a chemotherapeutic agent configured to treat cancer tissues in issue, a shell portion including a shell member encapsulating the core portion, antibodies configured to target cancer stem cells in issue and adhered to surface of said shell member. There is also provided a method comprising a step of exposing a target site in which the cancer cells reside to an energy source for effecting elevation of temperature of the magnetic nanoparticles, and release of the chemotherapeutic agent from the shell portion for destroying the cancer cells of the composition-cancer cell complex in the target site, wherein the energy source is an alternating magnetic field whereby extent of elevation of temperature and release of the chemotherapeutic agent is controllable by the alternating magnetic field.

摘要翻译： 提供了纳米颗粒组合物，其包含中心核心部分，其包括适于充当热源的磁性纳米颗粒和被配置用于治疗所述癌症组织的化学治疗剂，壳部分，包括封装核心部分的壳部件，构建成靶向癌症的抗体 干细胞问题并附着在所述壳体的表面上。 还提供了一种方法，其包括将癌细胞所在的靶位点暴露于能量源的步骤，以实现磁性纳米颗粒的温度升高，以及化学治疗剂从壳部分释放以破坏癌细胞 靶区域中的组成癌细胞复合物，其中能量源是交变磁场，由此可以通过交变磁场控制温度升高程度和化学治疗剂的释放程度。