公开(公告)号：US11905542B2

公开(公告)日：2024-02-20

申请号：US16648872

申请日：2018-09-25

Applicant: DSM IP ASSETS B.V.

Inventor： Nathalie Balch ,  Paul Blomquist ,  Reed Doten ,  Peter Houston ,  Ethan Lam ,  Jenna McMahon ,  Joshua Trueheart ,  Celine Viarouge

IPC: C12P23/00

CPC classification number: C12P23/00

Abstract: The present invention is related to a novel enzymatic process for production of retinyl esters, such as in particular retinyl long chain esters, via conversion of retinol, which process includes the use of enzymes having acyltransferase activity. Said process might be used for biotechnological production of vitamin A.

公开(公告)号：US10465174B2

公开(公告)日：2019-11-05

申请号：US14650298

申请日：2013-08-28

Applicant: DSM IP ASSETS B.V.

Inventor： Christopher Farrell ,  Peter Houston ,  Lisa Laprade ,  Nathalie Balch ,  Maria Mayorga

IPC: C12N15/00 ,  C12N1/20 ,  C12N15/04 ,  C12N9/10 ,  C12P23/00

Abstract: The present invention relates to novel acetyl transferases, nucleic acid sequences coding therefore, expression constructs and vectors comprising these sequences, microorganisms transformed therewith and use thereof.

公开(公告)号：US12252724B2

公开(公告)日：2025-03-18

申请号：US18161236

申请日：2023-01-30

Applicant: DSM IP ASSETS B.V.

Inventor： Nathalie Balch ,  Paul Blomquist ,  Reed Doten ,  Peter Houston ,  Ethan Lam ,  Jenna McMahon ,  Joshua Trueheart ,  Celine Viarouge

IPC: C12P7/22 ,  C12N9/04 ,  C12N9/10 ,  C12P7/62

Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.

公开(公告)号：US12049658B2

公开(公告)日：2024-07-30

申请号：US16648879

申请日：2018-09-25

Applicant: DSM IP ASSETS B.V.

Inventor： Nathalie Balch ,  Paul Blomquist ,  Reed Doten ,  Peter Houston ,  Ethan Lam ,  Jenna Mcmahon ,  Joshua Trueheart ,  Celine Viarouge ,  René Marcel De Jong

IPC: C12P23/00

CPC classification number: C12P23/00

Abstract: The present invention is related to production of retinyl esters, such as in particular retinyl acetate, an important building block for production of vitamin A. The retinyl esters might be generated via enzymatic conversion of retinol which process includes the use of enzymes with acetyl-transferase (ATF) activity, thus acetylating retinol into retinol/retinyl acetate. Said process is particularly useful for biotechnological production of vitamin A.

公开(公告)号：US11578344B2

公开(公告)日：2023-02-14

申请号：US16647730

申请日：2018-09-25

Applicant: DSM IP ASSETS B.V.

Inventor： Nathalie Balch ,  Paul Blomquist ,  Reed Doten ,  Peter Houston ,  Ethan Lam ,  Jenna McMahon ,  Joshua Trueheart ,  Celine Viarouge

IPC: C12P7/22 ,  C12N9/04 ,  C12N9/10 ,  C12P7/62

Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.