公开(公告)号：US20240123006A1

公开(公告)日：2024-04-18

申请号：US18546238

申请日：2022-02-15

Applicant: DSM IP ASSETS B.V.

Inventor： Joshua CLAYPOOL ,  Aaron COWIESON ,  Kevin FREEMAN ,  Ghislain SCHYNS

IPC: A61K36/06 ,  A23K10/30 ,  A23K20/158 ,  A23K20/163 ,  A23K50/75 ,  A61K31/05 ,  A61K31/4525 ,  A61P1/14

CPC classification number: A61K36/06 ,  A23K10/30 ,  A23K20/158 ,  A23K20/163 ,  A23K50/75 ,  A61K31/05 ,  A61K31/4525 ,  A61P1/14

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome improve the health and welfare of the animal. The present disclosure further relates to methods of modulating level of secondary metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level of tryptophan metabolism derivates.

公开(公告)号：US20230368914A1

公开(公告)日：2023-11-16

申请号：US18022361

申请日：2021-08-24

Applicant: DSM IP ASSETS B.V.

Inventor： Kevin FREEMAN ,  Joshua CLAYPOOL ,  Ghislain SCHYNS ,  Riccardo SFRISO

IPC: G16H50/20 ,  G16H50/30 ,  G16H20/60 ,  A61B5/00

CPC classification number: G16H50/20 ,  G16H50/30 ,  G16H20/60 ,  A61B5/4866

Abstract: In some aspects, the disclosure is directed to methods and systems for identifying a set of predictor metabolites which are predictive of a state of an animal subject. For that purpose, a plurality of data sets of respective ones of a plurality of animal subjects may be obtained, wherein each of the plurality of data sets comprises measurement data comprising an indication of a concentration of each of a plurality of metabolites in a sample of a microbiome of a respective animal subject. A label may be provided at least in part characterizing the state of the animal subject. A feature selection process may be applied to the plurality of data sets to select and thereby identify a subset of the plurality of metabolites of which subset the concentrations are a statistically significant predictor of the state according to the label.

公开(公告)号：US20240122953A1

公开(公告)日：2024-04-18

申请号：US18546264

申请日：2022-02-15

Applicant: DSM IP Assets B.V.

Inventor： Ghislain SCHYNS ,  Joshua CLAYPOOL ,  Kevin FREEMAN

IPC: A61K31/702 ,  A23K20/163 ,  A23K50/75 ,  A61P31/04 ,  C12Q1/689

CPC classification number: A61K31/702 ,  A23K20/163 ,  A23K50/75 ,  A61P31/04 ,  C12Q1/689 ,  C12Q2600/156

Abstract: The present disclosure relates to methods of modulating level of pathogenic E. coli (EHEC, EPEC, APEC) present in the gastrointestinal tract of an animal by administering saccharide compositions comprising an anhydro moiety. The presence/load with pathogenic E. coli strains can be assessed via the level of LEE and non-LEE pathogenic genes in the microbiome of the host animal.

公开(公告)号：US20240115669A1

公开(公告)日：2024-04-11

申请号：US18263818

申请日：2022-02-15

Applicant: DSM IP Assets B.V. ,  NOVOZYMES A/S

Inventor： Joshua CLAYPOOL ,  Kevin FREEMAN ,  Ghislain SCHYNS

IPC: A61K38/48 ,  A61K9/00 ,  A61K38/44 ,  A61K38/47 ,  A61P31/04 ,  C12Q1/689

CPC classification number: A61K38/48 ,  A61K9/0056 ,  A61K38/44 ,  A61K38/446 ,  A61K38/47 ,  A61P31/04 ,  C12Q1/689 ,  C12Y111/01006 ,  C12Y115/01001 ,  C12Y302/01017 ,  C12Q2600/156

Abstract: The present disclosure relates to methods of modulating level of E. coli present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level of LEE and non-LEE pathogenic genes in the microbiome of the host animal. The present disclosure further relates to methods of modulating the virulence of pathogenic E. coli in the gastrointestinal tract of an animal by reducing the population of B. thetaiotaomicron in the gut microbiome of the animal.

公开(公告)号：US20240099335A1

公开(公告)日：2024-03-28

申请号：US18263809

申请日：2022-02-15

Applicant: DSM IP Assets B.V. ,  NOVOZYMES A/S

Inventor： Joshua CLAYPOOL ,  Aaron COWIESON ,  Kevin FREEMAN ,  Ghislain SCHYNS

IPC: A23K20/189 ,  A23K50/75

CPC classification number: A23K20/189 ,  A23K50/75 ,  C12Y302/01092

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut micro-biome improve the health and welfare of the animal. The present disclosure further relates to methods of modulating level of secondary metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level of tryptophan metabolism derivates.