Somatotropin analogs
    3.
    发明授权
    Somatotropin analogs 失效
    生长激素类似物

    公开(公告)号:US5631227A

    公开(公告)日:1997-05-20

    申请号:US462255

    申请日:1995-06-05

    IPC分类号: C07K14/61 A61K38/27

    CPC分类号: C07K14/61

    摘要: The present invention provides analogs of somatotropins wherein the asparagine residue corresponding to position 99 of a bovine somatotropin is replaced with a compound selected from the group consisting of proline, aspartic acid, glutamic acid, serine, glycine, serine-serine or serine-aspartic acid. Particularly preferred analogs are bovine somatotropin and their use to increase milk production.

    摘要翻译: 本发明提供生长激素类似物,其中相应于牛生长激素的第99位的天冬酰胺残基被选自脯氨酸,天冬氨酸,谷氨酸,丝氨酸,甘氨酸,丝氨酸丝氨酸或丝氨酸 - 天冬氨酸的化合物所取代 。 特别优选的类似物是牛生长激素及其用于增加产奶量的用途。

    Power setting adjustments by mission operating system in response to requests from platform manager
    6.
    发明授权
    Power setting adjustments by mission operating system in response to requests from platform manager 有权
    任务操作系统根据平台经理的要求进行功率设置调整

    公开(公告)号:US08176498B2

    公开(公告)日:2012-05-08

    申请号:US11853134

    申请日:2007-09-11

    IPC分类号: G06F3/00 G09F1/00

    摘要: A computer system includes software running on a hardware platform. The hardware platform provides a platform manager having an user interface that is independent of that for a mission operating system running on said platform. The platform manager issues platform requests for power-setting adjustments. The software includes a mission operating system with a power controller incorporated in or running on the mission operating system. The power controller adjusts power settings for hardware devices at least in part as a function of the platform requests.

    摘要翻译: 计算机系统包括在硬件平台上运行的软件。 该硬件平台提供一个平台管理器,其具有独立于在所述平台上运行的任务操作系统的用户界面。 平台经理发布功率设置调整的平台请求。 该软件包括一个任务操作系统,该系统具有并入或运行在任务操作系统上的功率控制器。 功率控制器至少部分地根据平台请求调整硬件设备的功率设置。

    Method for the Preparation of Growth Hormone and Antagonist Thereof Having Lower Levels of Isoform Impurities Thereof
    7.
    发明申请
    Method for the Preparation of Growth Hormone and Antagonist Thereof Having Lower Levels of Isoform Impurities Thereof 有权
    用于制备具有较低水平的异型杂质的生长激素及其拮抗剂的方法

    公开(公告)号:US20100021966A1

    公开(公告)日:2010-01-28

    申请号:US12405857

    申请日:2009-03-17

    IPC分类号: C12N15/09

    CPC分类号: C07K1/18 C07K14/61

    摘要: The present invention is directed generally to recombinant methods for making a desired polypeptide. These method(s) yield a polypeptide product containing reduced levels of isoform impurities thereof. In particular, the present invention is directed to (1) a recombinant method for preparing growth hormone with reduced isoform impurities thereof and (2) a recombinant method for preparing a growth hormone antagonist, such as pegvisomant, and its protein intermediate, also having reduced isoform impurities thereof. More specifically, the isoform impurities that are decreased by methods of the present invention are the trisulfide and des-phe isoform impurities of growth hormone and growth hormone antagonist (or its intermediate), respectively.

    摘要翻译: 本发明一般涉及制备所需多肽的重组方法。 这些方法产生含有降低水平的异构体杂质的多肽产物。 特别地,本发明涉及(1)一种用于制备具有降低的同种型杂质的生长激素的重组方法和(2)一种用于制备生长激素拮抗剂的重组方法,所述生长激素拮抗剂例如栓塞坦及其蛋白质中间体, 其异构体杂质。 更具体地,通过本发明的方法减少的同种型杂质分别是生长激素和生长激素拮抗剂(或其中间体)的三硫化物和脱氢异构体杂质。

    Imidoester cross-linked hemoglobin compositions
    8.
    发明授权
    Imidoester cross-linked hemoglobin compositions 失效
    酰亚胺交联血红蛋白组成

    公开(公告)号:US5521154A

    公开(公告)日:1996-05-28

    申请号:US260173

    申请日:1994-06-15

    CPC分类号: C07K14/805 A61K38/00

    摘要: An imidoester, cross-linked hemoglobin composition useful in the transport of oxygen to living cells and being essentially free of any impurities, a P50 of at least 13mm Hg and predominantly in tetraruer form. Preferably, the cross-linked hemoglobin composition has a predominant molecular weight of at least 64,000. The purified and cross-linked hemoglobin has improved cross-link stability to autoxidation and can be used as a blood substitute for mammals or as an oxygen transport fluid.

    摘要翻译: 用于将氧气输送到活细胞并且基本上不含任何杂质的亚胺酯交联血红蛋白组合物,P50至少为13mm Hg,主要是四种形式。 优选地,交联血红蛋白组合物具有至少64,000的主要分子量。 纯化和交联的血红蛋白具有改善的自身氧化的交联稳定性,并且可以用作哺乳动物或氧输送液的血液替代物。

    Dynamically reallocating computing components between partitions
    10.
    发明授权
    Dynamically reallocating computing components between partitions 有权
    在分区之间动态重新分配计算组件

    公开(公告)号:US08407447B2

    公开(公告)日:2013-03-26

    申请号:US12639335

    申请日:2009-12-16

    IPC分类号: G06F12/02

    CPC分类号: G06F9/5077

    摘要: Systems, methods and computing components are provided for dynamically reallocating a plurality of computing components among one or more logical partitions. A first computing component that is allocated to a first partition may have a management processor. A second computing component may be allocated to a second partition. The management processor of the first computing component may be configured to reallocate the first computing component to a third partition without affecting the second computing component.

    摘要翻译: 提供了系统,方法和计算组件,用于在一个或多个逻辑分区之间动态地重新分配多个计算组件。 分配给第一分区的第一计算组件可以具有管理处理器。 可以将第二计算组件分配给第二分区。 第一计算组件的管理处理器可以被配置为将第一计算组件重新分配到第三分区而不影响第二计算组件。