公开(公告)号：US20070249615A1

公开(公告)日：2007-10-25

申请号：US11737966

申请日：2007-04-20

申请人： Robert Hughes ,  Andrew Bell ,  David Brown ,  Dafydd Owen ,  Michael Palmer ,  Christopher Phillips ,  David Brown ,  Yvette Fobian ,  John Freskos ,  Steven Heasley ,  E. Jacobsen ,  Todd Maddux ,  Brent Mischke ,  John Molyneaux ,  Joseph Moon ,  D. Rogier ,  Michael Tollefson ,  John Walker

发明人： Robert Hughes ,  Andrew Bell ,  David Brown ,  Dafydd Owen ,  Michael Palmer ,  Christopher Phillips ,  David Brown ,  Yvette Fobian ,  John Freskos ,  Steven Heasley ,  E. Jacobsen ,  Todd Maddux ,  Brent Mischke ,  John Molyneaux ,  Joseph Moon ,  D. Rogier ,  Michael Tollefson ,  John Walker

IPC分类号： A61K31/498 ,  C07D487/02

CPC分类号： C07D471/04

摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.

摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式I的结构：其中R 2，R 6A，R 6B， >和R＆gt; 8如说明书中所定义。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。

公开(公告)号：US20240026317A1

公开(公告)日：2024-01-25

申请号：US18249023

申请日：2021-10-13

申请人： Dong SHEN ,  David BROWN ,  Renxiang CHEN ,  RNAimmune, Inc

发明人： Dong Shen ,  David Brown ,  Renxiang Chen

IPC分类号： C12N9/14 ,  C12P19/30 ,  A61K39/00 ,  A61K9/127 ,  A61K47/69 ,  A61P35/00 ,  A61K47/54

CPC分类号： C12N9/14 ,  C12Y306/05002 ,  C12P19/30 ,  A61K39/001164 ,  A61K9/1273 ,  A61K47/6911 ,  A61P35/00 ,  A61K47/54 ,  A61K2039/53 ,  A61K2039/585 ,  A61K2039/55555

摘要： Compositions and methods are provided for potent mRNA vaccines for treatment of cancers with a mutation in the ras gene family. The compositions include a pharmaceutical composition comprising, or consisting essentially of, or yet further comprising mRNA molecules encoding at least one of multiple peptides of a group of somatic mutants and a pharmaceutically acceptable carrier. Methods for stimulating system immune responses and treatment are provided, including intratumoral, intravenous, intramuscular, intradermal, or subcutaneous injection of the composition as disclosed herein.

公开(公告)号：US11345606B2

公开(公告)日：2022-05-31

申请号：US15435318

申请日：2017-02-17

申请人： David Brown

发明人： David Brown

IPC分类号： G02B6/02 ,  C01G23/053 ,  C01G49/06 ,  C01B33/18

摘要： Disclosed is a method for producing deposition particles or intermediate particles, characterized in that the method comprises: forming a solution comprising a solvent and one or more deposit sources, aerosolizing the formed solution to produce an aerosol of precursor particles comprising the deposit source, conditioning the precursor particles to produce deposition particles or intermediate particles from the deposit source and collecting said particles. The particles may be collected as a deposit or precursor deposit on a substrate. The particles may include a matrix material and a dopant. The conditioning may be quenched to produce a desired substructure. The matrix material may be essentially optically clear. The substrate may comprise an optical fiber or an optical fiber preform or mandrel.

公开(公告)号：USD819777S1

公开(公告)日：2018-06-05

申请号：US29581051

申请日：2016-10-14

申请人： David Brown

设计人： David Brown

公开(公告)号：US20170128079A1

公开(公告)日：2017-05-11

申请号：US15343765

申请日：2016-11-04

申请人： David Brown

发明人： David Brown

IPC分类号： A61B17/15

CPC分类号： A61B17/155

摘要： An integrated instrument for arthroplasty planning comprises a cutting block having an adjustable distance between an anterior cut guide and a posterior cut guide, and a sizer mounted to the cutting block, the sizer comprising medial and lateral posterior feet having an adjustable distance from one of the cut guides and an adjustable angular position relative to the one of the cut guides.

公开(公告)号：US09612287B2

公开(公告)日：2017-04-04

申请号：US13461862

申请日：2012-05-02

申请人： David Brown ,  Christopher James Belcher ,  Duncan Joseph Brown ,  Dat Tan Chau

发明人： David Brown ,  Christopher James Belcher ,  Duncan Joseph Brown ,  Dat Tan Chau

IPC分类号： H02J7/00 ,  G01R31/36 ,  H02J9/04

CPC分类号： G01R31/3631 ,  G01R31/3658 ,  G01R31/3662 ,  H02J7/0021 ,  H02J9/04

摘要： Non-sequential monitoring of battery cells in battery monitoring systems, and related components, systems, and methods are disclosed. In one embodiment, a battery monitoring system control unit is provided. The battery monitoring system control unit is configured to control battery monitoring devices. Each battery monitoring device is configured to be coupled to a subset of battery cells electrically connected in series in a sequential order to form a battery. The battery monitoring system control unit is further configured to instruct the battery monitoring devices to test an ohmic value of each battery cell of the battery cells of the battery in a non-sequential order. In this manner, heat generated in the battery monitoring devices from the testing may be more effectively dissipated, which can also allow for the battery monitoring devices to be employed in higher operating temperature environments.

公开(公告)号：US20160130026A1

公开(公告)日：2016-05-12

申请号：US14534692

申请日：2014-11-06

申请人： David Brown ,  Sheletia Brown

发明人： David Brown ,  Sheletia Brown

IPC分类号： B65D1/02 ,  B65D41/04 ,  B65D47/06 ,  B65D1/40

CPC分类号： B65D1/0292 ,  B65D1/0284 ,  B65D1/40 ,  B65D2501/0036

摘要： A collapsible beverage containment assembly includes a bottle. The bottle has an outer wall extending between a top end and a bottom end of the bottle to contain a carbonated fluid. The outer wall is structured such that the bottle is collapsible. A sleeve is coupled to the bottom end. The sleeve is positioned within an interior of the bottle. A lid is movably coupled to the top end so the lid may be rotated. A screw is coupled to the lid such that the screw extends downwardly into the bottle. The screw engages the sleeve. Thus, the outer wall is collapsed when the lid is rotated to reduce a volume of the bottle, preserving the carbonation in the carbonated beverage.

摘要翻译： 可折叠的饮料容纳组件包括瓶子。 瓶子具有在瓶的顶端和底端之间延伸以容纳碳酸液体的外壁。 外壁的结构使得瓶子可折叠。 套筒连接到底端。 套筒位于瓶子的内部。 盖子可移动地联接到顶端，因此盖子可以旋转。 螺钉联接到盖上，使得螺钉向下延伸到瓶中。 螺钉接合套筒。 因此，当盖旋转以减小瓶的体积时，外壁被折叠，从而保持碳酸饮料中的碳酸化。

公开(公告)号：US09222085B2

公开(公告)日：2015-12-29

申请号：US13365646

申请日：2012-02-03

申请人： Kevin Kelnar ,  David Brown

发明人： Kevin Kelnar ,  David Brown

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113

CPC分类号： C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  C12N2310/141 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/3521

摘要： Embodiments concern methods and compositions involving miR-124 mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-124 sequence and a complementary passenger strand.

摘要翻译： 实施方案涉及涉及miR-124模拟物的方法和组合物。 在一些实施方案中，存在具有经修饰的核苷酸的双链RNA分子，其具有miR-124序列和补体乘客链的活性链。

公开(公告)号：US08639595B1

公开(公告)日：2014-01-28

申请号：US13045200

申请日：2011-03-10

申请人： Marc J. Brooker ,  Abhinav Agrawal ,  David Brown ,  Eric Jason Brandwine ,  Marvin M. Theimer

发明人： Marc J. Brooker ,  Abhinav Agrawal ,  David Brown ,  Eric Jason Brandwine ,  Marvin M. Theimer

IPC分类号： G07B17/00 ,  G07F19/00 ,  H04M15/00

CPC分类号： G06Q20/145 ,  G06Q20/14 ,  G06Q30/04 ,  H04M15/58

摘要： Techniques, including systems and methods, for virtual resource cost tracking account for unused capacity of implementation resources that is dedicated to particular customers and, as a result, is unusable for maintaining virtual resources for other customers. Customers requesting dedicated use of implementation resources are charged in a manner that compensates the virtual resource provider for the lost ability to use unused capacity of implementation resources to serve other customers. Customer charges may be determined by a pricing function that is calculated such that, for a base of customers, expected revenue from the base of customers approximates a revenue goal. The revenue goal may be determined based on revenue that would have been expected had the unused capacity of the dedicated implementation resources been available for serving other customers.

摘要翻译： 用于虚拟资源成本跟踪的技术，包括系统和方法，用于考虑专用于特定客户的实施资源的未使用容量，因此不能用于维护其他客户的虚拟资源。 要求专门使用实施资源的客户的收费方式是补偿虚拟资源提供商失去使用未实施资源的能力来为其他客户提供服务的能力。 客户费用可以由定价函数来确定，该定价函数的计算方式是，对于客户基础，来自客户基础的预期收入近似于收入目标。 收入目标可以根据专用实施资源的未使用容量可用于为其他客户提供服务而预期的收入确定。

公开(公告)号：US20130333710A1

公开(公告)日：2013-12-19

申请号：US13495582

申请日：2012-06-13

申请人： David Brown ,  Patrick Bryant

发明人： David Brown ,  Patrick Bryant

IPC分类号： A24C1/00 ,  A24B15/10

CPC分类号： A24B15/287 ,  A24B15/186 ,  A24C1/40 ,  A24D1/002

摘要： A method of applying precious and semi-precious metals to cigars such that the draw and ignitability of the cigar remains unaffected by the application. An embodiment of the present invention includes a composition and method of applying edible gold leaf to the external surface or wrapper of a cigar or rolled tobacco product.

摘要翻译： 贵金属和半贵金属应用于雪茄的方法，使得雪茄的拉丝和点火性不受应用影响。 本发明的一个实施方案包括将可食用金箔施用到雪茄或卷烟烟草制品的外表面或包装物上的组合物和方法。