公开(公告)号：US20070042001A1

公开(公告)日：2007-02-22

申请号：US11505694

申请日：2006-08-16

Applicant: Carolyn Weeks-Levy ,  David Clements ,  Steven Ogata

Inventor： Carolyn Weeks-Levy ,  David Clements ,  Steven Ogata

IPC: A61K39/145 ,  C07H21/04 ,  C12N7/00 ,  C12N5/06 ,  C07K14/11

CPC classification number: A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/55505 ,  A61K2039/55577 ,  A61K2039/70 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2800/105

Abstract: The invention provides influenza proteins, including subunit proteins and immunogenic compositions that can be utilized, with or without adjuvants, as vaccines to protect against influenza infection in animal models and humans. The recombinant proteins are expressed from transformed insect cells that contain integrated copies of the appropriate expression cassettes in their genome. The invention uses a Drosophila melanogaster expression system to provide high yields of recombinant subunit proteins with native-like conformation.

Abstract translation: 本发明提供流感蛋白，包括亚基蛋白和免疫原性组合物，其可以使用或不含佐剂，作为用于在动物模型和人类中防止流感感染的疫苗。 转化的昆虫细胞在其基因组中含有合适的表达盒的集成拷贝来表达重组蛋白质。 本发明使用黑腹果蝇表达系统提供具有天然样构象的高产量的重组亚基蛋白。

公开(公告)号：US20090151297A1

公开(公告)日：2009-06-18

申请号：US12093451

申请日：2006-11-10

Applicant: David Clements ,  Alan Benson

Inventor： David Clements ,  Alan Benson

IPC: E04B1/00 ,  E04G21/14 ,  E04B1/38

CPC classification number: H02B1/50

Abstract: A method for attaching a surface mountable unit to a ground surface, said method comprising (i) fixing a foundation frame, an upper portion of which is attachable to said surface mountable unit to the ground surface, and (ii) attaching the surface mountable unit to the upper portion of the foundation frame. Systems comprising combinations of foundation frames and surface mountable units and elements for use therein are also described and claimed.

Abstract translation: 一种用于将表面可安装单元附接到地面的方法，所述方法包括（i）将基部框架的上部固定到所述表面安装单元到地面上，以及（ii）将所述表面安装单元 到基础框架的上部。 还描述并要求保护包括基础框架和表面安装单元以及用于其中的元件的组合的系统。

公开(公告)号：US5960588A

公开(公告)日：1999-10-05

申请号：US822390

申请日：1997-03-20

Applicant: Georg Wurm ,  David Clements

Inventor： Georg Wurm ,  David Clements

IPC: B60J5/04 ,  E05F11/52 ,  E05F11/48

CPC classification number: B60J5/0416 ,  E05F11/488 ,  E05Y2201/684 ,  E05Y2201/702 ,  E05Y2600/20 ,  E05Y2900/55

Abstract: Apparatus for adjusting a frameless window pane moved by a cable window lifter in an automobile. The apparatus includes a first guide rail which has an unlocked and a locked state, and a second guide rail. The first guide rail is freely movable to a limited degree in the unlocked state and fixed in the locked state. A window pane is connected between the first guide rail and the second guide rail such that movement of the second guide rail causes the first guide rail to move when in its unlocked state. A bolt is provided for moving the second guide rail and for locking the first guide rail.

Abstract translation: 用于调节由汽车中的电缆窗升降机移动的无框窗玻璃的装置。 该装置包括具有解锁和锁定状态的第一导轨和第二导轨。 第一导轨可在解锁状态下自由移动到有限的程度并固定在锁定状态。 窗玻璃连接在第一导轨和第二导轨之间，使得当处于其解锁状态时，第二导轨的运动导致第一导轨移动。 提供用于移动第二导轨并锁定第一导轨的螺栓。

公开(公告)号：US20080008725A1

公开(公告)日：2008-01-10

申请号：US11506539

申请日：2006-08-16

Applicant: Carolyn Weeks-Levy ,  David Clements ,  Steven Ogata

Inventor： Carolyn Weeks-Levy ,  David Clements ,  Steven Ogata

IPC: A61K39/145 ,  C12N7/00

CPC classification number: A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/55505 ,  A61K2039/55577 ,  A61K2039/70 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2800/105

Abstract: The invention provides influenza proteins, including subunit proteins and immunogenic compositions that can be utilized, with or without adjuvants, as vaccines to protect against influenza infection in animal models and humans. The recombinant proteins are expressed from transformed insect cells that contain integrated copies of the appropriate expression cassettes in their genome. The invention uses a Drosophila melanogaster expression system to provide high yields of recombinant subunit proteins with native-like conformation.

Abstract translation: 本发明提供流感蛋白，包括亚基蛋白和免疫原性组合物，其可以使用或不含佐剂，作为用于在动物模型和人类中防止流感感染的疫苗。 转化的昆虫细胞在其基因组中含有合适的表达盒的集成拷贝来表达重组蛋白质。 本发明使用黑腹果蝇表达系统提供具有天然样构象的高产量的重组亚基蛋白。

公开(公告)号：US20070082011A1

公开(公告)日：2007-04-12

申请号：US11545093

申请日：2006-10-05

Applicant: Axel Lehrer ,  David Clements ,  Tom Humphreys

Inventor： Axel Lehrer ,  David Clements ,  Tom Humphreys

IPC: A61K39/395 ,  A61K39/12

CPC classification number: A61K39/12 ,  A61K2039/55566 ,  A61K2039/55577 ,  C07K14/005 ,  C12N2760/14122 ,  C12N2760/14134 ,  C12N2760/14222 ,  C12N2760/14234

Abstract: Filovirus subunit protein immunogens are produced using a recombinant expression system and combined with one or more adjuvants in immunogenic formulations. The subunit proteins include GP95, GP-FL, VP40, VP24, and NP derived from Ebola Virus and Marburg Virus. Adjuvants include saponins, emulsions, alum, and dipeptidyl peptidase inhibitors. The disclosed immunogenic formulations are effective in inducing strong antibody responses directed against individual Filovirus proteins and intact Filovirus particles as well as stimulating cell-mediated immune responses to the Filoviruses.

Abstract translation: 使用重组表达系统产生病毒亚单位蛋白免疫原，并与免疫原性制剂中的一种或多种佐剂组合。 亚基蛋白包括源自埃博拉病毒和马尔堡病毒的GP95，GP-FL，VP40，VP24和NP。 佐剂包括皂苷，乳液，明矾和二肽基肽酶抑制剂。 所公开的免疫原性制剂有效诱导针对单个病毒蛋白和完整的病毒颗粒的强抗体应答，以及刺激细胞介导的对病毒载体的免疫应答。

公开(公告)号：US6165477A

公开(公告)日：2000-12-26

申请号：US915152

申请日：1997-08-20

Applicant: John Ivy ,  Eilen Nakano ,  David Clements

Inventor： John Ivy ,  Eilen Nakano ,  David Clements

IPC: A61K39/00 ,  A61K39/12 ,  A61P31/12 ,  C07K14/18 ,  C07K16/10 ,  A61K39/193

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/6081 ,  C07K16/1081 ,  C07K2319/00 ,  C07K2319/02 ,  C12N2770/24122 ,  C12N2770/24134 ,  G01N2333/18 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396

Abstract: The Flaviviridae comprise a number of medically important pathogens that cause significant morbidity in humans including the dengue (DEN) virus, Japanese encephalitis (JE) virus, tick-borne encephalitis virus (TBE), and yellow fever virus (YF). Flaviviruses are generally transmitted to vertebrates by chronically infected mosquito or tick vectors. The viral particle which is enveloped by host cell membranes, comprises a single positive strand genomic RNA and the structural capsid (CA), membrane (M), and envelope (E) proteins. The E and M proteins are found on the surface of the virion where they are anchored in the membrane. Mature E is glycosylated and contains functional domains responsible for cell surface attachment and intraendosomal fusion activities. Problems have arisen in the art with respect to producing recombinant forms of the E glycoprotein that retain their native configuration and attendant properties associated therewith (i.e., ability to induce neutralizing antibody responses). To date, recombinantly produced E glycoproteins have suffered from a number of limitations including improper glycosylation, folding, and disulfide bond formation. The claimed invention has addressed these concerns by providing secreted recombinant forms of the E glycoprotein that are highly immunogenic and appear to retain their native configuration. Carboxy-terminally truncated forms of E containing the amino terminal 395 amino acids and a suitable secretion signal sequence were generated in Drosophila melanogaster Schneider cell lines. Immunogenic compositions comprising these recombinant envelope glycoproteins were capable of inducing protective, neutralizing antibody responses when administered to a suitable host.

Abstract translation: 黄病毒科包括许多在医学上重要的病原体，其引起人类重大的发病率，包括登革热（DEN）病毒，日本脑炎（JE）病毒，蜱传脑炎病毒（TBE）和黄热病病毒（YF）。 黄病毒一般通过慢性感染的蚊子或蜱载体传播给脊椎动物。 由宿主细胞膜包围的病毒颗粒包含单个正链基因组RNA和结构衣壳（CA），膜（M）和包膜（E）蛋白。 E和M蛋白存在于病毒粒子的表面，它们被锚定在膜中。 成熟的E被糖基化并且包含负责细胞表面附着和体内融合活性的功能结构域。 关于生产重组形式的E糖蛋白，其保留其天然构型和与其相关的伴随性质（即，诱导中和抗体应答的能力）方面出现了问题。 迄今为止，重组产生的E糖蛋白已经受到许多限制，包括不正确的糖基化，折叠和二硫键形成。 所要求保护的发明通过提供高度免疫原性并且看起来保持其天然构型的E糖蛋白的分泌重组形式来解决这些问题。 在黑腹果蝇施耐德细胞系中产生含有氨基末端395个氨基酸和合适的分泌信号序列的E的羧基末端截短形式。 包含这些重组包膜糖蛋白的免疫原性组合物在施用于合适的宿主时能够诱导保护性中和抗体应答。

公开(公告)号：US20160136050A1

公开(公告)日：2016-05-19

申请号：US15006748

申请日：2016-01-26

Applicant: David Clements

Inventor： David Clements

IPC: A61J1/18 ,  A61J1/10 ,  A61J1/16

CPC classification number: A61J1/18 ,  A61B90/90 ,  A61B90/92 ,  A61B90/94 ,  A61B90/96 ,  A61J1/00 ,  A61J1/035 ,  A61J1/10 ,  A61J2205/20 ,  A61J2205/50 ,  A61M5/31525 ,  A61M2005/3126

Abstract: An apparatus comprises a container comprising a volume. The volume is configured to retain a single dose of a medication appropriate for a specific classification of a weight of a patient. A first indicia is disposed on an exterior surface of the container. The first indicia indicates a type of the medication. A second indicia is disposed on the exterior surface. The second indicia indicates the specific classification, wherein the container, pre-packaged with the single dose, is appropriate for a single use dosing of the patient having the specific weight classification.

Abstract translation: 一种装置包括容器，其包括容积。 体积被配置为保留适合于患者重量的特定分类的单剂量的药物。 第一标记设置在容器的外表面上。 第一个标记表示一种药物。 第二标记设置在外表面上。 第二标记表示具体分类，其中用单剂量预包装的容器适合于具有特定重量分类的患者的单次使用剂量。

公开(公告)号：US20150174619A1

公开(公告)日：2015-06-25

申请号：US14313977

申请日：2014-06-24

Applicant: David Clements

Inventor： David Clements

IPC: B08B1/02 ,  A61L2/235 ,  B08B3/04

CPC classification number: B08B1/02 ,  A61L2/235 ,  B08B3/022 ,  B08B3/041 ,  B65H54/702 ,  B65H2701/34 ,  H02G11/02

Abstract: A system and method is provided for cleaning patient monitoring cables including: retracting a cable using a retraction mechanism; receiving, by a housing unit, the cable; and directing, based on movement of the cable, the cable into the housing unit. The innovation may further include: providing cleaning means to the housing unit; protracting the cable; and providing drying means to the housing unit.

Abstract translation: 提供了用于清洁患者监测电缆的系统和方法，包括：使用回缩机构缩回电缆; 由住房单元接收电缆; 并且基于电缆的移动将电缆引导到壳体单元中。 该创新还可以包括：向壳体单元提供清洁装置; 延长电缆; 以及向所述壳体单元提供干燥装置。

公开(公告)号：US06263975B1

公开(公告)日：2001-07-24

申请号：US09358439

申请日：1999-07-22

Applicant: Richard Rosa ,  James Marshall ,  David Clements

Inventor： Richard Rosa ,  James Marshall ,  David Clements

IPC: A01D5314

CPC classification number: A01D34/84

Abstract: A lawn edger includes an edge guide movable between a curb-edging mode and a trench mode. A lever is connected to the edge guide and extends through an aperture of a blade guard that is positioned to cover at least a portion of the cutting blade. The lever is positionable to move the edge guide between the curb-edging mode and the trench mode. When the edge guide is in the trench mode, the lever moves from a retracted position into an extended position, thereby providing a visual directional to the user.

Abstract translation: 草坪修剪器包括可在路缘边缘模式和沟槽模式之间移动的边缘引导件。 杠杆连接到边缘引导件并且延伸穿过刀片防护罩的孔，其被定位成覆盖切割刀片的至少一部分。 杠杆可定位以在边缘边缘模式和沟槽模式之间移动边缘引导件。 当边缘引导件处于沟槽模式时，杠杆从缩回位置移动到伸出位置，从而向使用者提供视觉方向。

公开(公告)号：US09271896B2

公开(公告)日：2016-03-01

申请号：US14311289

申请日：2014-06-21

Applicant: David Clements

Inventor： David Clements

IPC: A61M5/00 ,  A61J1/18 ,  A61B19/00

CPC classification number: A61J1/18 ,  A61B90/90 ,  A61B90/92 ,  A61B90/94 ,  A61B90/96 ,  A61J1/00 ,  A61J1/035 ,  A61J1/10 ,  A61J2205/20 ,  A61J2205/50 ,  A61M5/31525 ,  A61M2005/3126

Abstract: An apparatus having a container comprising a volume. The volume is configured to retain a single dose of a medication appropriate for a specific classification of a weight of a patient. A first indicia is disposed on an exterior surface of the container. The first indicia indicates a type of the medication. A second indicia is disposed on the exterior surface. The second indicia indicates the specific classification, wherein the container, pre-packaged with the single dose, is appropriate for a single use dosing of the patient having the specific classification.

Abstract translation: 一种具有容器的装置，包括容积。 体积被配置为保留适合于患者重量的特定分类的单剂量的药物。 第一标记设置在容器的外表面上。 第一个标记表示一种药物。 第二标记设置在外表面上。 第二标记表示具体分类，其中用单次剂量预先包装的容器适合于具有特定分类的患者的单次使用剂量。