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公开(公告)号:US20080288060A1
公开(公告)日:2008-11-20
申请号:US11631832
申请日:2005-07-06
申请人: David Martin Kaye , John Melmouth Power , Clifton A. Alferness , Adam Lucas Bilney , Mark L. Mathis
发明人: David Martin Kaye , John Melmouth Power , Clifton A. Alferness , Adam Lucas Bilney , Mark L. Mathis
IPC分类号: A61F2/24
CPC分类号: A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/068 , A61B17/221 , A61B2017/00243 , A61B2017/0409 , A61B2017/0441 , A61B2017/0445 , A61B2017/0448 , A61B2017/0453 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61B2017/0649 , A61B2017/081 , A61B2017/2215 , A61F2/2445
摘要: In a method of treating valvular insufficiency in a patient, a plurality of filaments (2) are used to engage tissue at spaced apart locations of an annulus (1) of the valve being treated. The engaged filaments (2) are drawn inward so as to draw the engaged tissue around the valve annulus (1) inward. The filaments (2) are then secured with the engaged tissue in the drawn-in configuration. Inward drawing of the engaged tissue improves valve function by reducing the valve annulus (1). Alternatively or additionally, anchor means may be used to secure the filaments to a region of robust tissue, thus drawing the engaged tissue toward the anchor means to further improve valve function.
摘要翻译: 在治疗患者瓣膜功能不全的方法中,多个细丝(2)用于在所治疗的瓣膜(1)的间隔开的位置处接合组织。 所接合的细丝(2)向内拉,以便将所接合的组织向内抽吸到瓣膜环(1)周围。 然后,细丝(2)以接合的组织固定在牵引构造中。 通过减小瓣膜环(1)来改变接合组织的内部抽吸来提高瓣膜功能。 或者或另外,锚固装置可以用于将细丝固定到坚固的组织的区域,从而将接合的组织拉向锚固装置以进一步改善瓣膜功能。
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公开(公告)号:US07942927B2
公开(公告)日:2011-05-17
申请号:US10592839
申请日:2005-03-09
IPC分类号: A61F2/24
CPC分类号: A61F2/2445
摘要: A device (1) for treating valve failure in a patient is provided. The device has one or more engaging zones (3) for engaging the device with the annulus of the valve being treated. The device also has pre-disposition means for changing the geometry of the device to a predetermined configuration which is suitable for constricting the valve annulus. The device is compressible for percutaneous delivery to the valve. When in the predetermined configuration, the engaged device constricts the valve annulus facilitating substantial closure of leaflets of the valve.
摘要翻译: 提供了一种用于治疗患者的阀门故障的装置(1)。 该装置具有一个或多个接合区域(3),用于将装置与正被处理的阀的环形空间接合。 该装置还具有用于将装置的几何形状改变为适合于收缩瓣膜环的预定构造的预设置装置。 该装置可压缩,用于经皮输送到阀门。 当处于预定构造时,接合装置限制阀环,从而有助于阀的传单的实质封闭。
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公开(公告)号:US20110015558A1
公开(公告)日:2011-01-20
申请号:US12803005
申请日:2010-06-16
CPC分类号: A61M1/3666 , A61B17/12136 , A61B2017/00252 , A61B2017/22068 , A61M1/32 , A61M1/3624 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M25/0074 , A61M25/0082 , A61M25/1002 , A61M25/1011 , A61M29/00 , A61M2025/0096 , A61M2025/1052 , A61M2202/07 , A61M2202/206 , A61M2210/125 , A61M2210/127
摘要: In a method for substantially isolating cardiac circulation from systemic circulation, flow between the coronary sinus and the right atrium is occluded. A venous collection device having a collection lumen and a support structure is located in the coronary sinus. The support structure is used to maintain patency of the coronary sinus during collection of fluid through the collection lumen. An artificial flow path is provided between the collection lumen and the one or more coronary arteries, thus isolating the cardiac circulation. According to the method, cardiac pumping for systemic circulation can be maintained during isolation of the cardiac circulation.
摘要翻译: 在用于基本上分离心脏循环与全身循环的方法中,阻塞冠状窦和右心房之间的流动。 具有收集腔和支撑结构的静脉收集装置位于冠状窦中。 支撑结构用于在通过收集腔收集流体期间保持冠状窦的通畅。 在收集腔和一个或多个冠状动脉之间提供人造流路,从而隔离心脏循环。 根据该方法,可以在分离心脏循环期间维持心脏泵送全身循环。
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公开(公告)号:US20080071364A1
公开(公告)日:2008-03-20
申请号:US10592839
申请日:2005-03-09
IPC分类号: A61F2/24
CPC分类号: A61F2/2445
摘要: A device (1) for treating valve failure in a patient is provided. The device has one or more engaging zones (3) for engaging the device with the annulus of the valve being treated. The device also has pre-disposition means for changing the geometry of the device to a predetermined configuration which is suitable for constricting the valve annulus. The device is compressible for percutaneous delivery to the valve. When in the predetermined configuration, the engaged device constricts the valve annulus facilitating substantial closure of leaflets of the valve.
摘要翻译: 提供了一种用于治疗患者的阀门故障的装置(1)。 该装置具有一个或多个接合区域(3),用于将装置与正被处理的阀的环形空间接合。 该装置还具有用于将装置的几何形状改变为适合于收缩瓣膜环的预定构造的预设置装置。 该装置可压缩,用于经皮输送到阀门。 当处于预定构造时,接合装置限制阀环,从而有助于阀的传单的实质封闭。
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公开(公告)号:US20090018526A1
公开(公告)日:2009-01-15
申请号:US11996416
申请日:2006-08-25
CPC分类号: A61M25/01 , A61F2/82 , A61M25/09 , A61M25/10 , A61M29/02 , A61M2025/09183 , A61M2025/1052
摘要: The present invention provides devices and methods for use in the perfusion of organs and anatomical regions. In one aspect the present method provides a percutaneously deliverable device for supporting a vessel in a human or animal subject including means for supporting the vessel during delivery of a fluid thereto or collection of a fluid therefrom. In another aspect the invention provides a method for delivery or collection of a fluid to or from an organ or anatomical region in a human or animal subject, the method including the step of supporting a vessel associated with the organ or anatomical region. The devices and methods may be used to deliver, remove or recirculate a therapeutic agent to an organ or anatomical region.
摘要翻译: 本发明提供了用于器官和解剖区域灌注中的装置和方法。 在一个方面,本方法提供了一种用于在人或动物对象中支撑血管的经皮递送装置,包括用于在输送流体或从其收集流体的过程中支撑血管的装置。 在另一方面,本发明提供了一种用于将流体递送或收集于人或动物受试者中的器官或解剖区域的方法,所述方法包括支撑与器官或解剖区域相关联的血管的步骤。 所述装置和方法可用于递送,移除或再循环治疗剂至器官或解剖区域。
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公开(公告)号:US07722596B2
公开(公告)日:2010-05-25
申请号:US11490476
申请日:2006-07-20
申请人: James Edward Shapland , Tuan Minh Doan , David Martin Kaye , Adam Lucas Bilney , Melissa Jane Byrne
发明人: James Edward Shapland , Tuan Minh Doan , David Martin Kaye , Adam Lucas Bilney , Melissa Jane Byrne
CPC分类号: A61M25/10 , A61B17/22 , A61B2017/22082 , A61M1/3653 , A61M1/3659 , A61M1/3667 , A61M25/104 , A61M2025/0031 , A61M2027/004
摘要: A method for treating an occlusion in a coronary artery of a patient includes percutaneously advancing an occlusion treatment tool (such as an angioplasty balloon or stent delivery device) through the vasculature of the patient and into a coronary artery to a site of the occlusion. Following the treatment of the occlusion, a therapeutic agent is admitted into the first coronary artery. The therapeutic agent is selected to treat microvasculature obstructions at a target cardiac tissue site distal to the site of the occlusion.
摘要翻译: 用于治疗患者冠状动脉闭塞的方法包括通过患者的脉管系统经皮推进闭塞治疗工具(例如血管成形术球囊或支架输送装置)并进入冠状动脉至闭塞部位。 治疗闭塞后,治疗剂进入第一冠状动脉。 治疗剂被选择用于治疗位于闭塞部位远端的靶心脏组织部位的微血管阻塞物。
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公开(公告)号:US08292871B2
公开(公告)日:2012-10-23
申请号:US12799007
申请日:2010-04-14
申请人: James Edward Shapland , Tuan Minh Doan , David Martin Kaye , Adam Lucas Bilney , Melissa Jane Byrne
发明人: James Edward Shapland , Tuan Minh Doan , David Martin Kaye , Adam Lucas Bilney , Melissa Jane Byrne
CPC分类号: A61M25/10 , A61B17/22 , A61B2017/22082 , A61M1/3653 , A61M1/3659 , A61M1/3667 , A61M25/104 , A61M2025/0031 , A61M2027/004
摘要: A method for treating an occlusion in a coronary artery of a patient includes percutaneously advancing an occlusion treatment tool (such as an angioplasty balloon or stent delivery device) through the vasculature of the patient and into a coronary artery to a site of the occlusion. Following the treatment of the occlusion, a therapeutic agent is admitted into the first coronary artery. The therapeutic agent is selected to treat microvasculature obstructions at a target cardiac tissue site distal to the site of the occlusion.
摘要翻译: 用于治疗患者冠状动脉闭塞的方法包括通过患者的脉管系统经皮推进闭塞治疗工具(例如血管成形术球囊或支架输送装置)并进入冠状动脉至闭塞部位。 治疗闭塞后,治疗剂进入第一冠状动脉。 治疗剂被选择用于治疗位于闭塞部位远端的靶心脏组织部位的微血管阻塞物。
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公开(公告)号:US20100274173A1
公开(公告)日:2010-10-28
申请号:US12799007
申请日:2010-04-14
申请人: James Edward Shapland , Tuan Minh Doan , David Martin Kaye , Adam Lucas Bilney , Melissa Jane Byrne
发明人: James Edward Shapland , Tuan Minh Doan , David Martin Kaye , Adam Lucas Bilney , Melissa Jane Byrne
CPC分类号: A61M25/10 , A61B17/22 , A61B2017/22082 , A61M1/3653 , A61M1/3659 , A61M1/3667 , A61M25/104 , A61M2025/0031 , A61M2027/004
摘要: A method for treating an occlusion in a coronary artery of a patient includes percutaneously advancing an occlusion treatment tool (such as an angioplasty balloon or stent delivery device) through the vasculature of the patient and into a coronary artery to a site of the occlusion. Following the treatment of the occlusion, a therapeutic agent is admitted into the first coronary artery. The therapeutic agent is selected to treat microvasculature obstructions at a target cardiac tissue site distal to the site of the occlusion.
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公开(公告)号:US20140328908A1
公开(公告)日:2014-11-06
申请号:US14238961
申请日:2012-08-16
IPC分类号: A61K9/28 , A61K45/06 , A61K9/48 , A61K31/444
CPC分类号: A61K9/2866 , A61K9/2072 , A61K9/2886 , A61K9/4808 , A61K9/4891 , A61K31/444 , A61K45/06 , A61K2300/00
摘要: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 μg/kg body weight/minute and 20 μg/kg body weight/minute.
摘要翻译: 本发明涉及5-(吡啶基)-2(1H) - 吡啶酮化合物的口服缓释制剂及其用于治疗患有心力衰竭,阶段,阶段或心脏衰竭表现或患有风险的受试者 发展或表现出心力衰竭症状。 本发明的制剂将化合物释放在0.1μg/ kg体重/分钟和20μg/ kg体重/分钟之间的范围内。
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公开(公告)号:US10137093B2
公开(公告)日:2018-11-27
申请号:US14238961
申请日:2012-08-16
IPC分类号: A61K9/20 , A61K9/28 , A61K9/48 , A61K31/444 , A61K45/06
摘要: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 μg/kg body weight/minute and 20 μg/kg body weight/minute.
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