公开(公告)号：US20060122048A1

公开(公告)日：2006-06-08

申请号：US11307451

申请日：2006-02-08

申请人： Dennis Hlavinka ,  William Palsulich ,  Thomas Felt ,  Frank Corbin

发明人： Dennis Hlavinka ,  William Palsulich ,  Thomas Felt ,  Frank Corbin

IPC分类号： B04B9/08

CPC分类号： A61M1/0209 ,  A61M1/3693 ,  B04B5/0428

摘要： A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.

摘要翻译： 公开了用于将复合流体离心分离成其组分的离心流体分离系统。 该离心分离系统至少包括离心转子，其具有复合流体容纳区域，流体流动通道/管道和限定在其中的至少一个分离的部件收集区域。 要分离的复合流体被输送到流体容纳区域，在离心力作用下，复合流体被分离成组分，然后组分通过出口通道行进到流过其中的各自分离的组分流体。 还提供了一个集中设置的泵以将分离的部件移动到收集区域。 分离的流体组分的界面的光学感测可以与夹具一起使用以阻止流动。 还公开了一次性袋和管道系统，用于可重复使用的转子装置。

公开(公告)号：US20060191857A1

公开(公告)日：2006-08-31

申请号：US11348524

申请日：2006-02-07

申请人： Dennis Hlavinka ,  Thomas Felt

发明人： Dennis Hlavinka ,  Thomas Felt

IPC分类号： B01D33/15

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  B04B5/0442 ,  B04B2005/045 ,  B04B2005/0471

摘要： An apparatus and method are provided for separating components of a fluid or particles. A separation vessel having a barrier dam is provided to initially separate an intermediate density components of a fluid, and a fluid chamber is provided to further separate these intermediate density components by forming an elutriative field or saturated fluidized particle bed. The separation vessel includes a shield for limiting flow into the fluid chamber of relatively high density substances, such as red blood cells. The separation vessel also includes a trap dam with a smooth, gradually sloped downstream section for reducing mixing of substances. Structure is also provided for adding additional plasma to platelets and plasma flowing from the fluid chamber. The system reduces clumping of platelets by limiting contact between the platelets and walls of the separation vessel.

公开(公告)号：US08277406B2

公开(公告)日：2012-10-02

申请号：US12633461

申请日：2009-12-08

申请人： Thomas Felt ,  Brian M. Holmes ,  Bruce Gibbs

发明人： Thomas Felt ,  Brian M. Holmes ,  Bruce Gibbs

IPC分类号： A61M37/00

CPC分类号： A61M1/3693 ,  A61M1/0218 ,  A61M1/0231 ,  A61M1/3633 ,  A61M1/3696 ,  A61M1/3698 ,  A61M1/38 ,  A61M2205/331 ,  B04B5/0428 ,  B04B5/0442 ,  B04B13/00 ,  B04B2013/006

摘要： A method for separating a volume of whole blood contained in a separation bag into at least three components comprising centrifuging the separation bag so as to separate therein a first inner layer comprising plasma, a second intermediate layer comprising platelets, a third intermediate layer comprising lymphocytes, monocytes and granulocytes and a fourth outer layer comprising red blood cells, transferring, into a plasma component bag connected to the separation bag, a plasma component and transferring into a mononuclear cell component bag a mononuclear cell components.

摘要翻译： 一种将包含在分离袋中的全血的体积分成至少三个组分的方法，包括离心分离袋，以便在其中分离包含血浆的第一内层，包含血小板的第二中间层，包含淋巴细胞的第三中间层， 单核细胞和粒细胞以及包含红细胞的第四外层，转移到与分离袋连接的血浆成分袋中的血浆成分，并将单核细胞成分转移到单核细胞成分袋中。

公开(公告)号：US08425448B2

公开(公告)日：2013-04-23

申请号：US11668715

申请日：2007-01-30

申请人： Thomas Felt ,  Peter Pihlstedt ,  Bruce Gibbs

发明人： Thomas Felt ,  Peter Pihlstedt ,  Bruce Gibbs

IPC分类号： A61M1/00 ,  A61M37/00 ,  B04B11/00 ,  B04B11/02 ,  B04B15/00

CPC分类号： A61M1/3496 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/3633 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/3698 ,  A61M1/38 ,  G01N33/491

摘要： This invention is directed to a method of collecting and separating whole blood into components. The method includes the steps of adding an anticoagulant having an acidic pH to a bag for collecting and/or separating whole blood, collecting whole blood in the bag, loading the bag containing anticoagulated whole blood on a rotor, spinning the bag on the rotor to separate the whole blood into at least one component; and squeezing the bag on the rotor to push the component from the separation bag into at least one satellite bag.

摘要翻译： 本发明涉及一种收集和分离全血成分的方法。 该方法包括以下步骤：将具有酸性pH的抗凝剂添加到用于收集和/或分离全血的袋中，在袋中收集全血，将含有抗凝血全血的袋装载在转子上，将转子上的袋旋转至 将全血分成至少一个组分; 并将袋子挤压在转子上以将组件从分离袋推入至少一个卫星袋中。

公开(公告)号：US07833185B2

公开(公告)日：2010-11-16

申请号：US11741081

申请日：2007-04-27

申请人： Thomas Felt ,  Brian M. Holmes ,  Bruce Gibbs

发明人： Thomas Felt ,  Brian M. Holmes ,  Bruce Gibbs

IPC分类号： A61M37/00

CPC分类号： A61M1/3693 ,  A61M1/0218 ,  A61M1/0231 ,  A61M1/3633 ,  A61M1/3696 ,  A61M1/3698 ,  A61M1/38 ,  A61M2205/331 ,  B04B5/0428 ,  B04B5/0442 ,  B04B13/00 ,  B04B2013/006

摘要： A method and apparatus for separating a volume of whole blood contained in a separation bag into at least three components comprising centrifuging the separation bag so as to separate therein a first inner layer comprising plasma, a second intermediate layer comprising platelets, a third intermediate layer comprising lymphocytes, monocytes and granulocytes and a fourth outer layer comprising red blood cells, transferring, into a plasma component bag connected to the separation bag, a plasma component and transferring into a mononuclear cell component bag a mononuclear cell components.

摘要翻译： 一种将包含在分离袋中的全血的体积分成至少三个组分的方法和装置，包括离心分离袋，以便在其中分离包含等离子体的第一内层，包含血小板的第二中间层，第三中间层， 淋巴细胞，单核细胞和粒细胞，以及包含红细胞的第四外层，转移到与分离袋连接的血浆成分袋中的血浆成分，并将单核细胞成分转移到单核细胞成分袋中。

公开(公告)号：US20070093774A1

公开(公告)日：2007-04-26

申请号：US11530131

申请日：2006-09-08

申请人： Thomas Felt ,  Marlene Bainbridge

发明人： Thomas Felt ,  Marlene Bainbridge

IPC分类号： A61B19/00

CPC分类号： A61M1/30 ,  A61M1/0209 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3496 ,  A61M1/36 ,  A61M1/3639 ,  A61M1/3641 ,  A61M1/3656 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2205/123 ,  A61M2205/17 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/50

摘要： This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes at least a two-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.

摘要翻译： 本发明提供一种用于控制流体分离系统的方法，优选具有白细胞减少室的血液分离系统。 该方法至少使用两级报警系统。 响应于系统中的压降而触发第一级报警条件以小于或等于指定的系统压力并在系统的至少一部分中暂停流体流动。 响应于指定时间内的指定数量的所述压降触发二级报警条件，并且降低系统中流体的流量。 报警条件也可能触发可见和/或声音报警。 当压降由非严重的，自分辨的或易于纠正的条件（例如系统部件的未对准）引起时，这些警报水平允许通过白细胞减少室流动。

公开(公告)号：US20070078368A1

公开(公告)日：2007-04-05

申请号：US11530122

申请日：2006-09-08

申请人： Thomas Felt ,  Marlene Bainbridge

发明人： Thomas Felt ,  Marlene Bainbridge

IPC分类号： A61M37/00

CPC分类号： A61M1/30 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3496 ,  A61M1/3639 ,  A61M1/3641 ,  A61M1/3656 ,  A61M1/3696 ,  A61M2205/123 ,  A61M2205/17 ,  A61M2205/18 ,  A61M2205/3331

摘要： This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a return-flow alarm system. A return-flow alarm-triggering pressure is specified, and when pressure of the return flow in the system is higher than or equal to the specified pressure, a return-flow alarm is triggered.

摘要翻译： 本发明提供一种用于控制流体分离系统的方法，优选具有白细胞减少室的血液分离系统。 该方法采用回流报警系统。 指定回流报警触发压力，当系统的回流压力大于或等于指定压力时，会触发回流报警。

公开(公告)号：US20070004997A1

公开(公告)日：2007-01-04

申请号：US11530111

申请日：2006-09-08

申请人： Thomas Felt ,  Marlene Bainbridge

发明人： Thomas Felt ,  Marlene Bainbridge

IPC分类号： A61M37/00

CPC分类号： A61M1/30 ,  A61M1/0209 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3496 ,  A61M1/36 ,  A61M1/3639 ,  A61M1/3641 ,  A61M1/3656 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2205/123 ,  A61M2205/17 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/50

摘要： This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a three-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.

摘要翻译： 本发明提供一种用于控制流体分离系统的方法，优选具有白细胞减少室的血液分离系统。 该方法采用三级报警系统。 响应于系统中的压降而触发第一级报警条件以小于或等于指定的系统压力并在系统的至少一部分中暂停流体流动。 响应于指定时间内的指定数量的所述压降触发二级报警条件，并且降低系统中流体的流量。 报警条件也可能触发可见和/或声音报警。 当压降由非严重的，自分辨的或易于纠正的条件（例如系统部件的未对准）引起时，这些警报水平允许通过白细胞减少室流动。