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    FLUID SEPARATION DEVICES, SYSTEMS AND/OR METHODS USING A CENTRIFUGE AND ROLLER PUMP
    1.
    发明申请
    FLUID SEPARATION DEVICES, SYSTEMS AND/OR METHODS USING A CENTRIFUGE AND ROLLER PUMP 失效
    使用离心泵和滚筒泵的流体分离装置，系统和/或方法

    公开(公告)号：US20060122048A1

    公开(公告)日：2006-06-08

    申请号：US11307451

    申请日：2006-02-08

    申请人： Dennis Hlavinka ,  William Palsulich ,  Thomas Felt ,  Frank Corbin

    发明人： Dennis Hlavinka ,  William Palsulich ,  Thomas Felt ,  Frank Corbin

    IPC分类号： B04B9/08

    CPC分类号： A61M1/0209 ,  A61M1/3693 ,  B04B5/0428

    摘要： A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.

    摘要翻译： 公开了用于将复合流体离心分离成其组分的离心流体分离系统。 该离心分离系统至少包括离心转子，其具有复合流体容纳区域，流体流动通道/管道和限定在其中的至少一个分离的部件收集区域。 要分离的复合流体被输送到流体容纳区域，在离心力作用下，复合流体被分离成组分，然后组分通过出口通道行进到流过其中的各自分离的组分流体。 还提供了一个集中设置的泵以将分离的部件移动到收集区域。 分离的流体组分的界面的光学感测可以与夹具一起使用以阻止流动。 还公开了一次性袋和管道系统，用于可重复使用的转子装置。

    Centrifugal separation apparatus and method for separating fluid components
    2.
    发明申请
    Centrifugal separation apparatus and method for separating fluid components 有权

    公开(公告)号：US20060191857A1

    公开(公告)日：2006-08-31

    申请号：US11348524

    申请日：2006-02-07

    申请人： Dennis Hlavinka ,  Thomas Felt

    发明人： Dennis Hlavinka ,  Thomas Felt

    IPC分类号： B01D33/15

    CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  B04B5/0442 ,  B04B2005/045 ,  B04B2005/0471

    摘要： An apparatus and method are provided for separating components of a fluid or particles. A separation vessel having a barrier dam is provided to initially separate an intermediate density components of a fluid, and a fluid chamber is provided to further separate these intermediate density components by forming an elutriative field or saturated fluidized particle bed. The separation vessel includes a shield for limiting flow into the fluid chamber of relatively high density substances, such as red blood cells. The separation vessel also includes a trap dam with a smooth, gradually sloped downstream section for reducing mixing of substances. Structure is also provided for adding additional plasma to platelets and plasma flowing from the fluid chamber. The system reduces clumping of platelets by limiting contact between the platelets and walls of the separation vessel.

    Method and apparatus for inactivation of biological contaminants using photosensitizers
    4.
    发明授权
    Method and apparatus for inactivation of biological contaminants using photosensitizers 有权
    使用光敏剂灭活生物污染物的方法和装置

    公开(公告)号：US06277337B1

    公开(公告)日：2001-08-21

    申请号：US09357188

    申请日：1999-07-20

    申请人： Raymond Paul Goodrich, Jr. ,  Dennis Hlavinka ,  Frank Corbin, III ,  Edward C. Wood, Jr.

    发明人： Raymond Paul Goodrich, Jr. ,  Dennis Hlavinka ,  Frank Corbin, III ,  Edward C. Wood, Jr.

    IPC分类号： B01J1908

    CPC分类号： A61L2/08 ,  A61L2/0011 ,  A61L2/0047 ,  A61L2/0052 ,  A61L2/0082 ,  A61L2/10 ,  A61L2/23 ,  A61L2202/22 ,  A61M1/3683 ,  C12N7/04

    摘要： Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to a fluid and exposing the fluid to photoradiation sufficient to activate the endogenous photosensitizer whereby microorganisms are inactivated. Other fluids, including juices, water and the like, may also be decontaminated by these methods as may surfaces of foods, animal carcasses, wounds, food preparation surfaces and bathing and washing vessel surfaces. Alloxazines and K- and L-vitamins are among the preferred photosensitizers. Systems and apparatuses for flow-through and batch processes are also provided for decontamination of such fluids using photosensitizers.

    摘要翻译： 提供了用于灭活流体或表面上的微生物的方法和装置。 优选地，流体含有血液或血液制品并且包含生物活性蛋白质。 优选的方法包括将有效的无毒量的内源性光敏剂加入到流体中并使流体暴露于足以激活内源性光敏剂从而使微生物灭活的步骤。 其他流体，包括果汁，水等也可以通过这些方法，如食品，动物屠体，伤口，食物制备表面和洗浴和洗涤容器表面的表面进行去污染。 Alloxazines和K-和L-维生素是优选的光敏剂之一。 还提供用于流通和间歇方法的系统和装置，用于使用光敏剂对这种流体进行去污染。

    Apparatus for reducing turbulence in fluid flow
    7.
    发明授权
    Apparatus for reducing turbulence in fluid flow 失效
    减少流体流动紊流的装置

    公开(公告)号：US5904645A

    公开(公告)日：1999-05-18

    申请号：US856071

    申请日：1997-05-14

    申请人： Dennis Hlavinka

    发明人： Dennis Hlavinka

    IPC分类号： B04B5/04 ,  B04B7/08

    CPC分类号： B04B5/0442 ,  B04B2005/045 ,  B04B2005/0471

    摘要： A centrifuge separation device is disclosed and includes a rotor configured to be connected to a centrifuge motor for rotation about an axis of rotation. A retainer is associated with the rotor and defines a passageway for a separation channel. A protrusion formed in one of the passageway walls extends towards and is spaced from the other of the passageway walls. The protrusion is sized to substantially block passage of materials in a predetermined density range and to substantially permit passage of materials outside of the predetermined density range. An indentation formed adjacent the protrusion in a wall of the passageway opposite the protrusion is configured to trap fluid during rotation of the rotor and to cooperate with the trapped fluid to maintain a substantially Coriolis-free pathway in a region of the passageway adjacent the protrusion.

    摘要翻译： 公开了一种离心机分离装置，其包括转子，该转子被配置为连接到离心机马达上以围绕旋转轴线旋转。 保持器与转子相关联并且限定用于分离通道的通道。 形成在其中一个通道壁中的突起朝向并且与另一个通道壁间隔开。 突起的尺寸被设计成基本上阻挡材料在预定的密度范围内的通过并且基本允许材料在预定的密度范围之外的通过。 在与突起相对的通道的壁中邻近突起形成的凹陷构造成在转子旋转期间捕获流体并与捕获的流体配合以在靠近突起的通道的区域中保持基本上无科里奥利的通道。

    Control system for the spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus
    8.
    发明授权
    Control system for the spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus 失效
    用于离心机中稀释组分如单核细胞的溢出收集的控制系统

    公开(公告)号：US5876321A

    公开(公告)日：1999-03-02

    申请号：US871244

    申请日：1997-06-09

    申请人： Dennis Hlavinka ,  Thomas J. Felt

    发明人： Dennis Hlavinka ,  Thomas J. Felt

    IPC分类号： A61K35/14 ,  B04B5/04 ,  B04B11/04

    CPC分类号： B04B5/0442 ,  B04B2005/045

    摘要： A centrifuge apparatus is used for collecting white blood cells (WBC), primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned in the separation vessel of the centrifuge at a location to intercept the thin layer. MNC fluid is allowed to pool behind the barrier before collection is started. To collect the MNC pool, the stratified red blood cell layer is raised from below the interface level by slowing or reversing flow in the RBC exit line thereby causing the MNC pool to spill over the barrier into a well in which a collect line is positioned. Collection ceases when a desired percentage of the pool is removed and the normal position of the interface is re-established; thereafter the pool builds again. By raising the MNC pool from below, improvements in purity and collect volume are achieved. The collection procedure can be useful for harvesting granulocytes and, in general, any sparse stratified component of a centrifuged solution where the sparse component is layered between more dense and less dense strata.

    摘要翻译： 离心机用于从分层成层的全血中收集白细胞（WBC），主要是单核细胞。 在红细胞和血浆的界面处形成薄单核（MNC）层。 隔离物位于离心机的分离容器中，以拦截薄层。 允许MNC流体在收集开始之前集中在障碍物后面。 为了收集MNC池，分层的红细胞层通过减缓或逆转RBC出口线中的流动而从界面水平以下升高，从而导致MNC池溢出障碍物进入收集线所在的井中。 当池的所需百分比被移除并且接口的正常位置被重新建立时，收集停止; 此后池再次建成。 通过从下方提高跨国公司池，实现了纯度和收集量的提高。 采集程序可用于收获粒细胞和一般来说，离心溶液的任何稀疏分层组分，其中稀疏组分分层在更致密和较不密集的层之间。

    Intermittent collection of mononuclear cells in a centrifuge apparatus
    9.
    发明授权
    Intermittent collection of mononuclear cells in a centrifuge apparatus 失效
    在离心机中间歇收集单核细胞

    公开(公告)号：US5879280A

    公开(公告)日：1999-03-09

    申请号：US871207

    申请日：1997-06-09

    申请人： Dennis Hlavinka ,  Thomas J. Felt

    发明人： Dennis Hlavinka ,  Thomas J. Felt

    IPC分类号： A61K35/14 ,  B04B5/04 ,  B04B11/04

    CPC分类号： B04B5/0442 ,  B04B2005/045

    摘要： A centrifuge apparatus is used for collecting white blood cells, primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned in the separation vessel of the centrifuge at a location to intercept the thin layer. An MNC collect port is positioned in front of the barrier to collect the thin layer. MNC fluid is allowed to pool behind the barrier to surround the collect port before collection is started. Collection ceases when the pool is removed and allowed to build again. By operating the collect in an intermittent fashion, improvements in purity and collect volume are achieved. The intermittent collection procedure can be useful for harvesting granulocytes and, in general, any sparse stratified component of a centrifuged solution where the sparse component is layered between more dense and less dense strata.

    摘要翻译： 离心机用于从分层分层的全血中收集白细胞，主要是单核细胞。 在红细胞和血浆的界面处形成薄单核（MNC）层。 隔离物位于离心机的分离容器中，以拦截薄层。 MNC收集端口位于屏障前面以收集薄层。 在收集开始之前，允许MNC流体在障碍物后面集中以围绕收集端口。 当池被移除并允许再次建立时，收集将停止。 通过间歇操作收集，实现了纯度和收集体积的提高。 间歇收集程序可用于收获粒细胞和一般来说，离散溶液的任何稀疏分层组分，其中稀疏组分分层在更致密和较不密集的层之间。