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公开(公告)号：US12187806B2
公开(公告)日：2025-01-07
申请号：US17686666
申请日：2022-03-04
Applicant: Development Center for Biotechnology
Inventor： Chun-Chung Lee , Yu-Hsun Lo , Chu-Bin Liao , Chen-Jei Hong , Sih-Yu Chen , Yen-Yu Wu , Szu-Liang Lai , Chih-Yung Hu , Wen-Bin Ke , Ya-Ting Juan , Kao-Jean Huang
IPC: C07K16/28 , A61K39/395 , A61K45/06 , A61P35/00 , A61K39/00
Abstract: The present invention relates to a novel antibody, an antigen-binding fragment thereof and the uses of the antibody and fragment, wherein the antibody and the fragment comprise specific complementarity-determining regions (CDRs) and/or specifically bind to human CD73 at specific epitopes.
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公开(公告)号：US10138300B2
公开(公告)日：2018-11-27
申请号：US15640935
申请日：2017-07-03
Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Inventor： Jiann-Shiun Lai , Li-Shuang Ai , Yan-Da Lai , Yen-Yu Wu , Yi-San Tsai , Yi-Jiue Tsai , Juo-Yu Huang , Cheng-Chou Yu , Chuan-Lung Hsu , Chien-Tsun Kuan , Szu-Liang Lai , Li-Ya Wang
IPC: C07K16/28 , C07K16/30 , G01N33/74 , A61K51/10 , A61K31/4439 , C07K14/71 , C07K16/00 , A61K47/68 , A61K47/48 , A61K39/00
Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.
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Patent Agency Ranking
公开(公告)号：US20180186884A1
公开(公告)日：2018-07-05
申请号：US15640935
申请日：2017-07-03
Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Inventor： JIANN-SHIUN LAI , Li-Shuang Ai , Yan-Da Lai , Yen-Yu Wu , Yi-San Tsai , Yi-Jiue Tsai , Juo-Yu Huang , Cheng-Chou Yu , Chuan-Lung Hsu , Chien-Tsun Kuan , Szu-Liang Lai , Li-Ya Wang
IPC: C07K16/28 , G01N33/74 , C07K16/30 , A61K51/10 , A61K31/4439
CPC classification number: C07K16/2863 , A61K31/4439 , A61K47/6803 , A61K47/6849 , A61K51/1027 , A61K51/1096 , A61K2039/505 , A61K2039/507 , C07K14/71 , C07K16/005 , C07K16/2818 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/74 , G01N2333/71
Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.
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公开(公告)号：US12043668B2
公开(公告)日：2024-07-23
申请号：US17413496
申请日：2019-12-13
Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Inventor： Chen-Hsuan Ho , Chu-Bin Liao , Yu-Kai Chen , Chen-Wei Huang , Tze-Ping Yang , Szu-Liang Lai
CPC classification number: C07K16/2866 , A61P35/00 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: An antibody, or an antigen-binding fragment thereof, that binds specifically to human CSF-1R includes a heavy chain variable domain that contains a HCDR1 region having the sequence of SEQ ID NO: 4, a HCDR2 region having the sequence of SEQ ID NO: 5, and a HCDR3 region having the sequence of SEQ ID NO: 6; and a light chain variable domain that contains a LCDR1 region having the sequence of SEQ ID NO: 7, a LCDR2 region having the sequence of SEQ ID NO: 8, and a LCDR3 region having the sequence of SEQ ID NO: 9. The heavy chain variable domain comprises the sequence of SEQ ID NO: 2, and wherein the light chain variable domain comprises the sequence of SEQ ID NO: 3.
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公开(公告)号：US20200048365A1
公开(公告)日：2020-02-13
申请号：US15988875
申请日：2018-05-24
Applicant: Development Center for Biotechnology
Inventor： Chia-Cheng Wu , Szu-Liang Lai , Yu-Jung Chen , Chih-Yung Hu , Tzu-Yin Lin
IPC: C07K16/34
Abstract: A humanized anti-Globo H antibody, or an scFv or Fab fragment thereof, comprising a heavy-chain variable domain having three complementary regions consisting of HCDR1, HCDR2, and HCDR3 and a light-chain variable domain having three complementary regions consisting of LCDR1, LCDR2, and LCDR3, wherein the sequence of HCDR1 is GYISSDQILN (SEQ ID NO:4), the sequence of HCDR2 is RIYPVTGVTQYXHKFVG (SEQ ID NO:5, wherein X is any amino acid), and the sequence of HCDR3 is GETFDS (SEQ ID NO:6), wherein the sequence of LCDR1 is KSNQNLLX′SGNRRYZLV (SEQ ID NO:7, wherein X′ is F, Y, or W, and Z is C, G, S or T), the sequence of LCDR2 is WASDRSF (SEQ ID NO:8), and the sequence of LCDR3 is QQHLDIPYT (SEQ ID NO:9).
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公开(公告)号：US12091454B2
公开(公告)日：2024-09-17
申请号：US18089812
申请日：2022-12-28
Inventor： Cheng-Chou Yu , Shu-Ping Yeh , Chao-Yang Huang , Szu-Liang Lai , Shih-Liang Hsiao , Mei-Ling Hou , Tzung-Jie Yang , Wei-Ting Sun , Liang-Yu Hsia , Andrew Yueh , Chiung-Tong Chen , Ren-Huang Wu , Pei-Shan Wu , Han-Shu Hu , Tzu-Chin Wu , Jia-Ni Tian
CPC classification number: C07K16/28 , A61P35/00 , C12N15/63 , C07K2317/24 , C07K2317/31
Abstract: A humanized anti-neurotensin receptor 1 (NTSR1) antibody or an antigen-binding fragment thereof. Also, a method for treating, prophylactic treating and/or preventing diseases and/or disorders caused by or related to NTSR1 activity and/or signaling, and a method or kit for detecting NTSR1 in a sample.
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公开(公告)号：US10781265B2
公开(公告)日：2020-09-22
申请号：US15988875
申请日：2018-05-24
Applicant: Development Center for Biotechnology
Inventor： Chia-Cheng Wu , Szu-Liang Lai , Yu-Jung Chen , Chih-Yung Hu , Tzu-Yin Lin
IPC: C07K16/34
Abstract: A humanized anti-Globo H antibody, or an scFv or Fab fragment thereof, comprising a heavy-chain variable domain having three complementary regions consisting of HCDR1, HCDR2, and HCDR3 and a light-chain variable domain having three complementary regions consisting of LCDR1, LCDR2, and LCDR3, wherein the sequence of HCDR1 is GYISSDQILN (SEQ ID NO:4), the sequence of HCDR2 is RIYPVTGVTQYXHKFVG (SEQ ID NO:5, wherein X is any amino acid), and the sequence of HCDR3 is GETFDS (SEQ ID NO:6), wherein the sequence of LCDR1 is KSNQNLLX′SGNRRYZLV (SEQ ID NO:7, wherein X′ is F, Y, or W, and Z is C, G, S or T), the sequence of LCDR2 is WASDRSF (SEQ ID NO:8), and the sequence of LCDR3 is QQHLDIPYT (SEQ ID NO:9).
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