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公开(公告)号：US12091454B2
公开(公告)日：2024-09-17
申请号：US18089812
申请日：2022-12-28
发明人： Cheng-Chou Yu , Shu-Ping Yeh , Chao-Yang Huang , Szu-Liang Lai , Shih-Liang Hsiao , Mei-Ling Hou , Tzung-Jie Yang , Wei-Ting Sun , Liang-Yu Hsia , Andrew Yueh , Chiung-Tong Chen , Ren-Huang Wu , Pei-Shan Wu , Han-Shu Hu , Tzu-Chin Wu , Jia-Ni Tian
CPC分类号： C07K16/28 , A61P35/00 , C12N15/63 , C07K2317/24 , C07K2317/31
摘要： A humanized anti-neurotensin receptor 1 (NTSR1) antibody or an antigen-binding fragment thereof. Also, a method for treating, prophylactic treating and/or preventing diseases and/or disorders caused by or related to NTSR1 activity and/or signaling, and a method or kit for detecting NTSR1 in a sample.
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公开(公告)号：US11384150B2
公开(公告)日：2022-07-12
申请号：US16467655
申请日：2017-12-13
发明人： Shih-Hsien Chuang , Wei-Ting Chao , Wei-Ting Sun , Hui-Jan Hsu , Wun-Huei Lin
IPC分类号： C07K16/28 , A61K47/68 , A61P35/00 , C07K16/30 , A61K38/00 , A61K45/06 , A61K39/00 , A61K39/395
摘要： An immunoconjugate, comprising an anti-EGFR antibody or a binding fragment thereof, and a kinase inhibitor.
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公开(公告)号：US20210015942A1
公开(公告)日：2021-01-21
申请号：US16244090
申请日：2019-01-09
发明人： Shih-Hsien Chuang , Chu-Bin Liao , Wei-Ting Sun , Chen-Hsien Liang , Wun-Huei Lin , Chun-Liang Lai , Her-Sheng Lin
摘要： An immunoconjugate having the Formula Ab-[L1-(A-L2-B)m]n, wherein: (a) Ab is an antibody or a binding fragment thereof; (b) L1 and L2 are each independently a linker, wherein L1 and L2 are the same or different and wherein L1 links to L2; (c) A is a target-protein ligand/binder; (d) B is a ubiquitin ligase ligand/binder, and (e) n and m are independently integers from 1 to 8. The target protein includes kinase, G protein-coupled receptors, transcription factor, phosphatases, and RAS superfamily members.
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公开(公告)号：US11998613B2
公开(公告)日：2024-06-04
申请号：US17339747
申请日：2021-06-04
发明人： Shih-Hsien Chuang , Wei-Ting Sun , Ying-Shuan Lailee , Chun-Liang Lai , Wun-Huei Lin , Win-Yin Wei , Shih-Chong Tsai , Cheng-Chou Yu , Chao-Yang Huang
CPC分类号： A61K47/6851 , A61K47/545 , A61K47/6803 , A61K47/6817 , A61K47/6889 , A61P35/00
摘要： The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.
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