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公开(公告)号：US20090253797A1
公开(公告)日：2009-10-08
申请号：US12477413
申请日：2009-06-03
IPC分类号： A61K31/198 , A61P21/06
CPC分类号： A61K31/198 , A23K20/105 , A23K20/142 , A23L33/10 , A23V2002/00 , A23V2250/306
摘要： Creatine oral supplementation using creatine hydrochloride salt, that may be added to a liquid or other beverage, or may be also used as an additive to solid oral dosages, or as a supplement, and which may be consumed by the athlete, or other party looking for immediate supplementation of strength, and may be added as a supplement within feed to livestock, in the veterinary area.
摘要翻译： 使用肌酸盐酸盐的肌酸口服补充剂，其可以加入到液体或其它饮料中，或者也可以用作固体口服剂量或作为补充剂的添加剂，并且可以由运动员或其他方观察 立即补充力量，并可在兽医领域作为畜牧饲料添加补充。
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公开(公告)号：US20110034421A1
公开(公告)日：2011-02-10
申请号：US12909377
申请日：2010-10-21
IPC分类号： A61K31/195 , C07C279/14 , A61K31/661 , A61P21/06
CPC分类号： A61K31/198 , A23K20/10 , A23K20/105 , A23K20/142 , A23K50/10 , A23L2/52 , A23L33/10 , A23L33/175 , A23P10/40 , A23V2002/00 , A61K9/0053 , A61K31/185 , A61K31/195 , A61K31/661 , A23V2250/306 , A23V2200/33 , A23V2200/316
摘要： The present invention is directed to a third generation form of creatine, specifically a creatine hydrochloride salt, that drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.
摘要翻译： 本发明涉及第三代肌酸，特别是肌酸盐酸盐，其由于其增强的生物可利用性而促进肌肉发育和恢复的显着改善，同时与以前的肌酸形式相比，引起较少的负面副作用。
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公开(公告)号：US08354450B2
公开(公告)日：2013-01-15
申请号：US12909377
申请日：2010-10-21
IPC分类号： A61K31/195
CPC分类号： A61K31/198 , A23K20/10 , A23K20/105 , A23K20/142 , A23K50/10 , A23L2/52 , A23L33/10 , A23L33/175 , A23P10/40 , A23V2002/00 , A61K9/0053 , A61K31/185 , A61K31/195 , A61K31/661 , A23V2250/306 , A23V2200/33 , A23V2200/316
摘要： The present invention is directed to a third generation form of creatine, specifically a creatine hydrochloride salt, that drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.
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公开(公告)号：US08026385B2
公开(公告)日：2011-09-27
申请号：US12477413
申请日：2009-06-03
IPC分类号： C07C229/00 , A61K31/195
CPC分类号： A61K31/198 , A23K20/105 , A23K20/142 , A23L33/10 , A23V2002/00 , A23V2250/306
摘要： Creatine oral supplementation using creatine hydrochloride salt, that may be added to a liquid or other beverage, or may be also used as an additive to solid oral dosages, or as a supplement, and which may be consumed by the athlete, or other party looking for immediate supplementation of strength, and may be added as a supplement within feed to livestock, in the veterinary area.
摘要翻译： 使用肌酸盐酸盐的肌酸口服补充剂，其可以加入到液体或其它饮料中，或者也可以用作固体口服剂量或作为补充剂的添加剂，并且可以由运动员或其他方观察 立即补充力量，并可在兽医领域作为畜牧饲料添加补充。
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公开(公告)号：US07608641B2
公开(公告)日：2009-10-27
申请号：US10846782
申请日：2004-05-14
IPC分类号： A61K31/195
CPC分类号： A61K31/198 , A23K20/105 , A23K20/142 , A23L33/10 , A23V2002/00 , A23V2250/306
摘要： Creatine oral supplementation using creatine hydrochloride salt, that may be added to a liquid or other beverage, or may be also used as an additive to solid oral dosages, or as a supplement, and which may be consumed by the athlete, or other party looking for immediate supplementation of strength, and may be added as a supplement within feed to livestock, in the veterinary area.
摘要翻译： 使用肌酸盐酸盐的肌酸口服补充剂，其可以加入到液体或其它饮料中，或者也可以用作固体口服剂量或作为补充剂的添加剂，并且可以由运动员或其他方观察 立即补充力量，并可在兽医领域作为畜牧饲料添加补充。
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6.发明申请CREATINE ESTER PRONUTRIENT COMPOUNDS AND FORMULATIONS 审中-公开CRETINE ESTER PRONUTRIENT COMPOUNDS AND FORMULATIONS公开(公告)号：US20110172306A1
公开(公告)日：2011-07-14
申请号：US13069697
申请日：2011-03-23
IPC分类号： A61K31/221 , C07C257/14 , A61P3/02 , A61P25/16 , A61P25/00 , A61P21/00 , A61P9/00
CPC分类号： A23K20/142 , A23L33/10 , A23V2002/00 , A61K31/198 , A61K31/22 , A61K31/221 , A61K31/66 , A61K31/7004 , A23V2250/306
摘要： The present invention describes a method for providing creatine to an animal, which includes receiving a creatine ester by the animal. The creatine ester is suitable for being modified by the animal to form creatine.
摘要翻译： 本发明描述了向动物提供肌酸的方法，其包括由动物接受肌酸酯。 肌酸酯适合被动物修饰以形成肌酸。
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公开(公告)号：US06906205B2
公开(公告)日：2005-06-14
申请号：US10742010
申请日：2003-12-19
申请人： Jonathan L. Vennerstrom , Yuxiang Dong , Jacques Chollet , Hugues Matile , Maniyan Padmanilayam , Yuangqing Tang , William N. Charman
发明人： Jonathan L. Vennerstrom , Yuxiang Dong , Jacques Chollet , Hugues Matile , Maniyan Padmanilayam , Yuangqing Tang , William N. Charman
IPC分类号： A61K31/335 , C07D323/02 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/06 , C07D417/12 , C07D491/10 , C07D491/20 , C07D493/10 , C07D495/10 , A61K31/357
CPC分类号： C07D405/06 , A61K31/335 , C07D323/02 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/06 , C07D417/12 , C07D491/10 , C07D493/10 , C07D495/10 , Y02A50/411 , Y02A50/423
摘要： A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
摘要翻译： 描述了使用螺或二脱氧-1,2,4-三恶烷来治疗疟疾，血吸虫病和癌症的方法和方法。 优选的1,2,4-三氧杂环戊烷在三氧杂环戊烷基的一侧包括一个双金刚烷基，在三氧杂环戊烷基的另一侧包括一个螺环己基，因此螺环己基环优选在4位被取代。 与青蒿素半合成衍生物相比，本发明的化合物在结构上简单，易于合成，无毒，对抗疟疾寄生虫有效。
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公开(公告)号：US06486199B1
公开(公告)日：2002-11-26
申请号：US09886666
申请日：2001-06-21
IPC分类号： A61K31335
CPC分类号： C07D405/12 , A61K31/335 , A61K31/357 , C07D323/02 , C07D405/14 , C07D491/10 , C07D493/10 , C07D495/10 , Y02A50/411 , Y02A50/423 , A61K2300/00
摘要： A means and method for treating malaria using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl or spiropiperidyl ring on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably functionalized or substituted at the 4-position or a spiropiperidyl ring that is functionalized or substituted at the nitrogen atom. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
摘要翻译： 描述了使用螺或二脱氧-1,2,4-三恶烷处理疟疾的方法和方法。 优选的1,2,4-三氧杂环戊烷包括在三氧杂环戊烷基一侧的双金刚烷基，三氧杂环戊烷基的另一侧上的螺环己基或螺哌啶环，其中螺环己基环优选在4位官能化或取代 或在氮原子上被官能化或取代的螺哌啶基环。 与青蒿素半合成衍生物相比，本发明的化合物在结构上简单，易于合成，无毒，对抗疟疾寄生虫有效。
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公开(公告)号：US07371778B2
公开(公告)日：2008-05-13
申请号：US11121451
申请日：2005-05-04
申请人： Jonathan L. Vennerstrom , Yuxiang Dong , Jacques Chollet , Hugues Matile , Xiaofang Wang , Kamaraj Spiraghavan , William N. Chapman
发明人： Jonathan L. Vennerstrom , Yuxiang Dong , Jacques Chollet , Hugues Matile , Xiaofang Wang , Kamaraj Spiraghavan , William N. Chapman
IPC分类号： A61K31/357 , C07D323/02
CPC分类号： A61K31/335 , C07D323/02 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/06 , C07D417/12 , C07D491/10 , C07D493/10 , C07D495/10 , Y02A50/411 , Y02A50/423
摘要： A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
摘要翻译： 描述了使用螺或二脱氧-1,2,4-三恶烷来治疗疟疾，血吸虫病和癌症的方法和方法。 优选的1,2,4-三氧杂环戊烷在三氧杂环戊烷基的一侧包括一个双金刚烷基，在三氧杂环戊烷基的另一侧包括一个螺环己基，因此螺环己基环优选在4位被取代。 与青蒿素半合成衍生物相比，本发明的化合物在结构上简单，易于合成，无毒，对抗疟疾寄生虫有效。
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公开(公告)号：US06825230B2
公开(公告)日：2004-11-30
申请号：US10642721
申请日：2003-08-18
申请人： Jonathan L. Vennerstrom , Yuxiang Dong , Jacques Chollet , Hugues Matile , Maniyan Padmanilayam , Yuanqing Tang , William N. Charman
发明人： Jonathan L. Vennerstrom , Yuxiang Dong , Jacques Chollet , Hugues Matile , Maniyan Padmanilayam , Yuanqing Tang , William N. Charman
IPC分类号： A61K31357
CPC分类号： C07D405/06 , A61K31/335 , A61K31/4747 , C07D323/02 , C07D405/12 , C07D417/06 , Y02A50/411 , Y02A50/423
摘要： A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
摘要翻译： 描述了使用螺或二脱氧-1,2,4-三恶烷来治疗疟疾，血吸虫病和癌症的方法和方法。 优选的1,2,4-三氧杂环戊烷在三氧杂环戊烷基的一侧包括一个双金刚烷基，在三氧杂环戊烷基的另一侧包括一个螺环己基，因此螺环己基环优选在4位被取代。 与青蒿素半合成衍生物相比，本发明的化合物在结构上简单，易于合成，无毒，对抗疟疾寄生虫有效。
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