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公开(公告)号:US20050282862A1
公开(公告)日:2005-12-22
申请号:US10629817
申请日:2003-07-29
申请人: Douglas Beight , Trelia Craft , Carl Denny , Jeffry Franciskovich , Theodore Goodson , Steven Hall , David Herron , Sajan Joseph , Valentine Klimkowski , Jeffrey Kyle , John Masters , David Mendel , Guy Milot , Marta Pineiro-Nunez , Jason Sawyer , Robert Shuman , Gerald Smith , Anne Tebbe , Jennifer Tinsley , Leonard Weir , James Wikel , Michael Wiley , Ying Yee
发明人: Douglas Beight , Trelia Craft , Carl Denny , Jeffry Franciskovich , Theodore Goodson , Steven Hall , David Herron , Sajan Joseph , Valentine Klimkowski , Jeffrey Kyle , John Masters , David Mendel , Guy Milot , Marta Pineiro-Nunez , Jason Sawyer , Robert Shuman , Gerald Smith , Anne Tebbe , Jennifer Tinsley , Leonard Weir , James Wikel , Michael Wiley , Ying Yee
IPC分类号: A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P7/02 , A61P9/10 , C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D41/02
CPC分类号: C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译: 本申请涉及如本文所定义的式I化合物(或其药学上可接受的盐),其药物组合物及其作为因子Xa抑制剂的用途,以及其制备方法及其中间体。
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公开(公告)号:US06716855B2
公开(公告)日:2004-04-06
申请号:US10374124
申请日:2003-02-25
申请人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号: A61K3144
CPC分类号: C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号:US06780878B2
公开(公告)日:2004-08-24
申请号:US10382614
申请日:2003-03-05
申请人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号: C07D31202
CPC分类号: C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号:US06716839B2
公开(公告)日:2004-04-06
申请号:US10378108
申请日:2003-02-26
申请人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号: A61K315377
CPC分类号: C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号:US06635657B1
公开(公告)日:2003-10-21
申请号:US09857751
申请日:2001-06-08
申请人: Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人: Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号: A61K314545
CPC分类号: C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译: 本申请涉及如本文所定义的式I化合物(或其药学上可接受的盐),其药物组合物及其作为因子Xa抑制剂的用途,以及其制备方法及其中间体。
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公开(公告)号:US07129245B2
公开(公告)日:2006-10-31
申请号:US10629817
申请日:2003-07-29
申请人: Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Pi{hacek over (n)}elro-Nú{hacek over (n)}ez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人: Douglas Wade Beight , Trelia Joyce Craft , Carl Penman Denny , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Pi{hacek over (n)}elro-Nú{hacek over (n)}ez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号: A61K31/506 , C07D239/04
CPC分类号: C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号:US06689780B1
公开(公告)日:2004-02-10
申请号:US09857749
申请日:2001-06-08
申请人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Nuñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Nuñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号: C07D40114
CPC分类号: C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14
摘要: This application relates to heteroaromatic amides (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译: 本申请涉及本文定义的杂芳族酰胺(或其药学上可接受的盐),其药物组合物及其作为因子Xa抑制剂的用途,以及其制备方法及其中间体。
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公开(公告)号:US06710057B2
公开(公告)日:2004-03-23
申请号:US10377906
申请日:2003-02-28
申请人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson, Jr. , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Piñeiro-Núñez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号: A61K314545
CPC分类号: C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
摘要翻译: 本申请涉及如本文所定义的式I化合物(或其药学上可接受的盐),其药物组合物及其作为因子Xa抑制剂的用途,以及其制备方法及其中间体。
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公开(公告)号:US06610704B1
公开(公告)日:2003-08-26
申请号:US09857747
申请日:2001-06-08
申请人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Pineiro-Nunez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
发明人: Douglas Wade Beight , Trelia Joyce Craft , Jeffry Bernard Franciskovich , Theodore Goodson , Steven Edward Hall , David Kent Herron , Sajan Joseph , Valentine Joseph Klimkowski , Jeffrey Alan Kyle , John Joseph Masters , David Mendel , Guy Milot , Marta Maria Pineiro-Nunez , Jason Scott Sawyer , Robert Theodore Shuman , Gerald Floyd Smith , Anne Louise Tebbe , Jennifer Marie Tinsley , Leonard Crayton Weir , James Howard Wikel , Michael Robert Wiley , Ying Kwong Yee
IPC分类号: C07D21302
CPC分类号: C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要: This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermidates thereof.
摘要翻译: 本申请涉及如本文所定义的式(I)化合物(或其药学上可接受的盐),其药物组合物及其作为因子Xa抑制剂的用途,以及其制备方法及其中间体。
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公开(公告)号:US07700628B2
公开(公告)日:2010-04-20
申请号:US11719415
申请日:2005-11-10
申请人: Ankush Baburao Argade , Theodore Goodson, Jr. , David Kent Herron , Sajan Joseph , Salvatore Donato Lepore , Angela Lynn Marquart , John Joseph Masters , David Mendel , Leander Merritt , Andrew Michael Ratz , Gerald Floyd Smith , Anne Louise Tebbe , Michael Robert Wiley , Ying Kwong Yee
发明人: Ankush Baburao Argade , Theodore Goodson, Jr. , David Kent Herron , Sajan Joseph , Salvatore Donato Lepore , Angela Lynn Marquart , John Joseph Masters , David Mendel , Leander Merritt , Andrew Michael Ratz , Gerald Floyd Smith , Anne Louise Tebbe , Michael Robert Wiley , Ying Kwong Yee
IPC分类号: C07D413/10 , C07D413/14 , C07D401/10 , C07D401/02 , C07D401/14 , C07D401/12 , C07D409/10 , C07D243/08 , C07D213/75 , A61K31/381 , A61K31/4402 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/551
CPC分类号: C07D211/46 , C07C229/38 , C07D213/75 , C07D295/192 , C07D333/38 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/12
摘要: This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
摘要翻译: 本申请涉及如本文所定义的式(I)化合物(或其化合物或前药的药学上可接受的盐),其药物组合物及其作为因子Xa和/或凝血酶抑制剂的用途,以及 其制备方法及其中间体。 式(I)化合物的实例是(a)。
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