公开(公告)号：US06716855B2

公开(公告)日：2004-04-06

申请号：US10374124

申请日：2003-02-25

申请人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Piñeiro-Núñez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

发明人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Piñeiro-Núñez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

IPC分类号： A61K3144

CPC分类号： C07D295/135 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14

摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

公开(公告)号：US06710057B2

公开(公告)日：2004-03-23

申请号：US10377906

申请日：2003-02-28

申请人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Piñeiro-Núñez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

发明人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Piñeiro-Núñez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

IPC分类号： A61K314545

CPC分类号： C07D295/135 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14

摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

摘要翻译： 本申请涉及如本文所定义的式I化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。

公开(公告)号：US06780878B2

公开(公告)日：2004-08-24

申请号：US10382614

申请日：2003-03-05

申请人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Piñeiro-Núñez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

发明人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Piñeiro-Núñez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

IPC分类号： C07D31202

CPC分类号： C07D295/135 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14

摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

公开(公告)号：US06716839B2

公开(公告)日：2004-04-06

申请号：US10378108

申请日：2003-02-26

申请人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Piñeiro-Núñez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

发明人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Piñeiro-Núñez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

IPC分类号： A61K315377

CPC分类号： C07D295/135 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14

摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

公开(公告)号：US06635657B1

公开(公告)日：2003-10-21

申请号：US09857751

申请日：2001-06-08

申请人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Carl Penman Denny ,  Jeffry Bernard Franciskovich ,  Theodore Goodson ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Piñeiro-Núñez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

发明人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Carl Penman Denny ,  Jeffry Bernard Franciskovich ,  Theodore Goodson ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Piñeiro-Núñez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

IPC分类号： A61K314545

CPC分类号： C07D213/75 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

摘要翻译： 本申请涉及如本文所定义的式I化合物（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。

公开(公告)号：US07129245B2

公开(公告)日：2006-10-31

申请号：US10629817

申请日：2003-07-29

申请人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Carl Penman Denny ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Pi{hacek over (n)}elro-Nú{hacek over (n)}ez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

发明人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Carl Penman Denny ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Pi{hacek over (n)}elro-Nú{hacek over (n)}ez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

IPC分类号： A61K31/506 ,  C07D239/04

CPC分类号： C07D213/75 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

摘要： This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

公开(公告)号：US06689780B1

公开(公告)日：2004-02-10

申请号：US09857749

申请日：2001-06-08

申请人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Piñeiro-Nuñez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

发明人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Sajan Joseph ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Marta Maria Piñeiro-Nuñez ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

IPC分类号： C07D40114

CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

摘要： This application relates to heteroaromatic amides (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

摘要翻译： 本申请涉及本文定义的杂芳族酰胺（或其药学上可接受的盐），其药物组合物及其作为因子Xa抑制剂的用途，以及其制备方法及其中间体。

公开(公告)号：US06500851B2

公开(公告)日：2002-12-31

申请号：US10082453

申请日：2002-02-22

申请人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

发明人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

IPC分类号： A61K31416

CPC分类号： C07D401/14 ,  C07D209/08 ,  C07D209/30 ,  C07D231/56 ,  C07D235/06 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12

摘要： This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

公开(公告)号：US06605626B2

公开(公告)日：2003-08-12

申请号：US09961164

申请日：2001-09-21

申请人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

发明人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

IPC分类号： A61K3144

CPC分类号： C07D209/48 ,  C07C233/75 ,  C07C235/56 ,  C07C237/40 ,  C07C237/42 ,  C07C237/44 ,  C07C257/18 ,  C07C259/18 ,  C07C307/10 ,  C07C311/08 ,  C07C311/09 ,  C07C311/16 ,  C07C311/21 ,  C07C317/44 ,  C07C317/50 ,  C07C2603/18 ,  C07D209/58 ,  C07D209/64 ,  C07D211/22 ,  C07D211/34 ,  C07D211/46 ,  C07D211/62 ,  C07D211/78 ,  C07D211/96 ,  C07D213/30 ,  C07D213/56 ,  C07D213/70 ,  C07D213/75 ,  C07D261/10 ,  C07D277/56 ,  C07D295/185 ,  C07D307/85 ,  C07D317/58 ,  C07D333/70 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D417/06

摘要： This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

公开(公告)号：US06313122B1

公开(公告)日：2001-11-06

申请号：US09445972

申请日：2000-03-20

申请人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

发明人： Douglas Wade Beight ,  Trelia Joyce Craft ,  Jeffry Bernard Franciskovich ,  Theodore Goodson, Jr. ,  Steven Edward Hall ,  David Kent Herron ,  Valentine Joseph Klimkowski ,  Jeffrey Alan Kyle ,  John Joseph Masters ,  David Mendel ,  Guy Milot ,  Jason Scott Sawyer ,  Robert Theodore Shuman ,  Gerald Floyd Smith ,  Anne Louise Tebbe ,  Jennifer Marie Tinsley ,  Leonard Crayton Weir ,  James Howard Wikel ,  Michael Robert Wiley ,  Ying Kwong Yee

IPC分类号： A61K314545

CPC分类号： C07D209/48 ,  C07C233/75 ,  C07C235/56 ,  C07C237/40 ,  C07C237/42 ,  C07C237/44 ,  C07C257/18 ,  C07C259/18 ,  C07C307/10 ,  C07C311/08 ,  C07C311/09 ,  C07C311/16 ,  C07C311/21 ,  C07C317/44 ,  C07C317/50 ,  C07C2603/18 ,  C07D209/58 ,  C07D209/64 ,  C07D211/22 ,  C07D211/34 ,  C07D211/46 ,  C07D211/62 ,  C07D211/78 ,  C07D211/96 ,  C07D213/30 ,  C07D213/56 ,  C07D213/70 ,  C07D213/75 ,  C07D261/10 ,  C07D277/56 ,  C07D295/185 ,  C07D307/85 ,  C07D317/58 ,  C07D333/70 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D417/06

摘要： This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.