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公开(公告)号：US20070100137A1
公开(公告)日：2007-05-03
申请号：US11387269
申请日：2006-03-23
申请人： Douglas Dellinger , Zoltan Timar , Agnieszka Sierzchala , Geraldine Dellinger , Marvin Caruthers , Joel Myerson
发明人： Douglas Dellinger , Zoltan Timar , Agnieszka Sierzchala , Geraldine Dellinger , Marvin Caruthers , Joel Myerson
IPC分类号： C07H21/04
摘要： Methods of deprotecting polynucleotides are disclosed.
摘要翻译： 公开了脱保护多核苷酸的方法。
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2.发明申请Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection 有权用于合成RNA的单体组合物，合成方法和脱保护方法公开(公告)号：US20070100136A1
公开(公告)日：2007-05-03
申请号：US11388112
申请日：2006-03-23
申请人： Douglas Dellinger , Zoltan Timar , Agnieszka Sierzchala , Geraldine Dellinger , Marvin Caruthers
发明人： Douglas Dellinger , Zoltan Timar , Agnieszka Sierzchala , Geraldine Dellinger , Marvin Caruthers
摘要： Nucleotide monomers, polynucleotides, methods of making making each, methods of deprotecting each, and the like are disclosed herein.
摘要翻译： 本文公开了核苷酸单体，多核苷酸，制备各自的方法，各自的脱保护方法等。
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公开(公告)号：US20050048601A1
公开(公告)日：2005-03-03
申请号：US10652054
申请日：2003-08-30
摘要： Methods of forming an internucleotide bond are disclosed. Such methods find use in synthesis of polynucleotides. The method involves contacting a functionalized support with a precursor having an exocyclic amine triaryl methyl protecting group under conditions and for a time sufficient to result in internucleotide bond formation. The functionalized support includes a solid support, a triaryl methyl linker group, and a nucleoside moiety having a reactive site hydroxyl, the nucleoside moiety attached to the solid support via the triaryl methyl linker group.
摘要翻译： 公开了形成核苷酸间键的方法。 这些方法可用于多核苷酸的合成。 该方法包括使官能化的载体与具有环外胺三芳基甲基保护基团的前体在足以导致形成核苷酸键的条件下进行接触。 官能化载体包括固体支持物，三芳基甲基连接基团和具有反应性位点羟基的核苷部分，所述核苷部分通过三芳基甲基连接基团连接到固体支持物上。
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公开(公告)号：US20070099859A1
公开(公告)日：2007-05-03
申请号：US11388339
申请日：2006-03-23
IPC分类号： A61K48/00 , A61K31/7076 , A61K31/7072
摘要： In certain embodiments of the invention, novel compositions having a phosphorus group and a phosphorus protecting group bound to the phosphorus group are provided, and methods of deprotecting the phosphorus group are provided.
摘要翻译： 在本发明的某些实施方案中，提供了具有与磷基结合的磷基和磷保护基的新型组合物，并且提供了使磷基脱保护的方法。
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5.发明授权Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection 有权用于合成RNA的单体组合物，合成方法和脱保护方法公开(公告)号：US07759471B2
公开(公告)日：2010-07-20
申请号：US11388112
申请日：2006-03-23
申请人： Douglas J. Dellinger , Zoltan Timar , Agnieszka Sierzchala , Geraldine Dellinger , Marvin H. Caruthers
发明人： Douglas J. Dellinger , Zoltan Timar , Agnieszka Sierzchala , Geraldine Dellinger , Marvin H. Caruthers
IPC分类号： C07H19/00 , C07H19/067 , C07H19/167 , C07H21/02
摘要： Nucleotide monomers, polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein.
摘要翻译： 本文公开了核苷酸单体，多核苷酸，制备方法，各自的脱保护方法等。
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公开(公告)号：US08552174B2
公开(公告)日：2013-10-08
申请号：US11387269
申请日：2006-03-23
申请人： Douglas J. Dellinger , Zoltan Timar , Agnieszka Sierzchala , Geraldine Dellinger , Marvin H. Caruthers , Joel Myerson
发明人： Douglas J. Dellinger , Zoltan Timar , Agnieszka Sierzchala , Geraldine Dellinger , Marvin H. Caruthers , Joel Myerson
IPC分类号： C07H21/00
摘要： Methods of deprotecting polynucleotides are disclosed. One aspect of the method of deprotecting polynucleotides, among others, includes: providing a polynucleotide, wherein the polynucleotide includes at least one nucleotide monomer that has at least one protecting group selected from the following: a base having a protecting group, a 2′-hydroxyl protecting group, and a combination thereof, and deprotecting at least one of the protecting groups of the polynucleotide by introducing the polynucleotide to a solution including an α-effect nucleophile.
摘要翻译： 公开了脱保护多核苷酸的方法。 多核苷酸脱保护方法的一个方面包括：提供多核苷酸，其中所述多核苷酸包括至少一种具有至少一个选自以下的保护基的核苷酸单体：具有保护基的碱，2'- 羟基保护基团及其组合，并通过将多核苷酸引入到包含α-效应亲核试剂的溶液中来去保护多核苷酸的至少一个保护基团。
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公开(公告)号：US20070224602A1
公开(公告)日：2007-09-27
申请号：US11389326
申请日：2006-03-23
CPC分类号： C07H21/04
摘要： In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.
摘要翻译： 在本发明的各种实施方案中，提供了具有通过可切割连接子与底物结合的多核苷酸的新型组合物，并提供了从底物切割多核苷酸的方法。
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公开(公告)号：US07572908B2
公开(公告)日：2009-08-11
申请号：US11389388
申请日：2006-03-23
IPC分类号： C07H21/00
CPC分类号： C07H21/04
摘要： In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.
摘要翻译： 在本发明的各种实施方案中，提供了具有通过可切割连接子与底物结合的多核苷酸的新型组合物，并提供了从底物切割多核苷酸的方法。
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公开(公告)号：US07855281B2
公开(公告)日：2010-12-21
申请号：US11389326
申请日：2006-03-23
CPC分类号： C07H21/04
摘要： In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.
摘要翻译： 在本发明的各种实施方案中，提供了具有通过可切割连接子与底物结合的多核苷酸的新型组合物，并提供了从底物切割多核苷酸的方法。
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公开(公告)号：US20070224603A1
公开(公告)日：2007-09-27
申请号：US11389388
申请日：2006-03-23
CPC分类号： C07H21/04
摘要： In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.
摘要翻译： 在本发明的各种实施方案中，提供了具有通过可切割连接子与底物结合的多核苷酸的新型组合物，并提供了从底物切割多核苷酸的方法。
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