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公开(公告)号：US20060003377A1
公开(公告)日：2006-01-05
申请号：US11214199
申请日：2005-08-29
申请人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
发明人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K2319/00 , C07K2319/43 , C07K2319/60 , C12N15/8509 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。
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公开(公告)号：US20050208521A1
公开(公告)日：2005-09-22
申请号：US10991181
申请日：2004-11-17
申请人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
发明人： Douglas Hilton , Warren Alexander , Elizabeth Viney , Tracy Willson , Rachael Richardson , Robyn Starr , Sandra Nicholson , Donald Metcalf , Nicos Nicola
IPC分类号： A61K38/00 , C07H21/04 , C07K14/47 , C12N15/09 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/564 , G01N33/574 , G01N33/68
CPC分类号： G01N33/564 , A61K38/00 , C07K14/4703 , G01N33/574 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。
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公开(公告)号：US07279557B2
公开(公告)日：2007-10-09
申请号：US10991181
申请日：2004-11-17
申请人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
CPC分类号： G01N33/564 , A61K38/00 , C07K14/4703 , G01N33/574 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。
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公开(公告)号：US20080166730A1
公开(公告)日：2008-07-10
申请号：US11977132
申请日：2007-10-23
申请人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
IPC分类号： C12Q1/68
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。
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公开(公告)号：US07049418B2
公开(公告)日：2006-05-23
申请号：US09908805
申请日：2001-07-19
申请人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
IPC分类号： C07H17/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K2319/00 , C07K2319/43 , C07K2319/60 , C12N15/8509 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。
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公开(公告)号：US06905842B1
公开(公告)日：2005-06-14
申请号：US08962560
申请日：1997-10-31
申请人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
IPC分类号： A61K38/00 , C07H21/04 , C07K14/47 , C12N15/09 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/564 , G01N33/574 , G01N33/68 , C21P21/06 , C14P14/00
CPC分类号： G01N33/564 , A61K38/00 , C07K14/4703 , G01N33/574 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
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公开(公告)号：US06323317B1
公开(公告)日：2001-11-27
申请号：US09302769
申请日：1999-04-30
申请人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人： Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
IPC分类号： C07K100
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K2319/00 , C07K2319/43 , C07K2319/60 , C12N15/8509 , G01N33/6863
摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。
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