公开(公告)号：US07049418B2

公开(公告)日：2006-05-23

申请号：US09908805

申请日：2001-07-19

申请人： Douglas J. Hilton ,  Warren S. Alexander ,  Elizabeth M. Viney ,  Tracy A. Willson ,  Rachael T. Richardson ,  Robyn Starr ,  Sandra E. Nicholson ,  Donald Metcalf ,  Nicos A. Nicola

发明人： Douglas J. Hilton ,  Warren S. Alexander ,  Elizabeth M. Viney ,  Tracy A. Willson ,  Rachael T. Richardson ,  Robyn Starr ,  Sandra E. Nicholson ,  Donald Metcalf ,  Nicos A. Nicola

IPC分类号： C07H17/00

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K2319/00 ,  C07K2319/43 ,  C07K2319/60 ,  C12N15/8509 ,  G01N33/6863

摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.

摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。

公开(公告)号：US06905842B1

公开(公告)日：2005-06-14

申请号：US08962560

申请日：1997-10-31

申请人： Douglas J. Hilton ,  Warren S. Alexander ,  Elizabeth M. Viney ,  Tracy A. Willson ,  Rachael T. Richardson ,  Robyn Starr ,  Sandra E. Nicholson ,  Donald Metcalf ,  Nicos A. Nicola

发明人： Douglas J. Hilton ,  Warren S. Alexander ,  Elizabeth M. Viney ,  Tracy A. Willson ,  Rachael T. Richardson ,  Robyn Starr ,  Sandra E. Nicholson ,  Donald Metcalf ,  Nicos A. Nicola

IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K14/47 ,  C12N15/09 ,  C12P21/06 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/564 ,  G01N33/574 ,  G01N33/68 ,  C21P21/06 ,  C14P14/00

CPC分类号： G01N33/564 ,  A61K38/00 ,  C07K14/4703 ,  G01N33/574 ,  G01N33/6863

摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.

公开(公告)号：US07279557B2

公开(公告)日：2007-10-09

申请号：US10991181

申请日：2004-11-17

申请人： Douglas J. Hilton ,  Warren S. Alexander ,  Elizabeth M. Viney ,  Tracy A. Willson ,  Rachael T. Richardson ,  Robyn Starr ,  Sandra E. Nicholson ,  Donald Metcalf ,  Nicos A. Nicola

发明人： Douglas J. Hilton ,  Warren S. Alexander ,  Elizabeth M. Viney ,  Tracy A. Willson ,  Rachael T. Richardson ,  Robyn Starr ,  Sandra E. Nicholson ,  Donald Metcalf ,  Nicos A. Nicola

IPC分类号： C07K14/00 ,  C07H17/00

CPC分类号： G01N33/564 ,  A61K38/00 ,  C07K14/4703 ,  G01N33/574 ,  G01N33/6863

摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.

摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。

公开(公告)号：US06323317B1

公开(公告)日：2001-11-27

申请号：US09302769

申请日：1999-04-30

申请人： Douglas J. Hilton ,  Warren S. Alexander ,  Elizabeth M. Viney ,  Tracy A. Willson ,  Rachael T. Richardson ,  Robyn Starr ,  Sandra E. Nicholson ,  Donald Metcalf ,  Nicos A. Nicola

发明人： Douglas J. Hilton ,  Warren S. Alexander ,  Elizabeth M. Viney ,  Tracy A. Willson ,  Rachael T. Richardson ,  Robyn Starr ,  Sandra E. Nicholson ,  Donald Metcalf ,  Nicos A. Nicola

IPC分类号： C07K100

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K2319/00 ,  C07K2319/43 ,  C07K2319/60 ,  C12N15/8509 ,  G01N33/6863

摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.

摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。

公开(公告)号：US20080166730A1

公开(公告)日：2008-07-10

申请号：US11977132

申请日：2007-10-23

申请人： Douglas J. Hilton ,  Warren S. Alexander ,  Elizabeth M. Viney ,  Tracy A. Willson ,  Rachael T. Richardson ,  Robyn Starr ,  Sandra E. Nicholson ,  Donald Metcalf ,  Nicos A. Nicola

发明人： Douglas J. Hilton ,  Warren S. Alexander ,  Elizabeth M. Viney ,  Tracy A. Willson ,  Rachael T. Richardson ,  Robyn Starr ,  Sandra E. Nicholson ,  Donald Metcalf ,  Nicos A. Nicola

IPC分类号： C12Q1/68

摘要： The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.

摘要翻译： 本发明一般涉及治疗和诊断剂。 更具体地，本发明提供能够调节信号转导的治疗分子，例如但不限于细胞因子介导的信号转导。 因此，本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子，抗原，微生物和微生物产物，病毒或其组分，离子，激素和寄生虫的细胞反应性。

公开(公告)号：US5902584A

公开(公告)日：1999-05-11

申请号：US693241

申请日：1997-01-21

申请人： Sandra E. Nicholson ,  Judith E. Layton ,  Andrew F. Wilks ,  Andrew C. Oates ,  Ailsa G. Harpur

发明人： Sandra E. Nicholson ,  Judith E. Layton ,  Andrew F. Wilks ,  Andrew C. Oates ,  Ailsa G. Harpur

IPC分类号： A61K38/00 ,  A61P37/02 ,  C07K16/28 ,  A61K39/395 ,  C07K16/00

CPC分类号： C07K16/2866 ,  A61K38/00

摘要： The invention relates to a composition comprising antibodies or binding portions thereof which bind to a naturally occurring or recombinant G-CSF receptor extracellular domain, and reduce tyrosine phosphorylation of a JAK molecule. The invention also relates to methods of using this composition for inhibiting or decreasing tyrosine phosphorylation of a JAK kinase and for inhibiting or decreasing G-CSF interaction with its receptor. Also described are antibodies which bind to a G-CSF receptor extracellular domain and which are produced by immunizing an animal with cells transfected with DNA encoding a G-CSF receptor.

摘要翻译： PCT No.PCT / US95 / 01696 Sec。 371日期1997年1月21日 102（e）日期1997年1月21日PCT提交1995年2月8日PCT公布。 出版物WO95 / 21864 日期1995年8月17日本发明涉及包含结合天然存在或重组G-CSF受体细胞外结构域的抗体或其结合部分并减少JAK分子的酪氨酸磷酸化的组合物。 本发明还涉及使用该组合物抑制或减少JAK激酶的酪氨酸磷酸化并抑制或降低与其受体的G-CSF相互作用的方法。 还描述了结合G-CSF受体细胞外结构域并且通过用编码G-CSF受体的DNA转染的细胞免疫动物产生的抗体。