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公开(公告)号:US07279557B2
公开(公告)日:2007-10-09
申请号:US10991181
申请日:2004-11-17
申请人: Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人: Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
CPC分类号: G01N33/564 , A61K38/00 , C07K14/4703 , G01N33/574 , G01N33/6863
摘要: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译: 本发明一般涉及治疗和诊断剂。 更具体地,本发明提供能够调节信号转导的治疗分子,例如但不限于细胞因子介导的信号转导。 因此,本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子,抗原,微生物和微生物产物,病毒或其组分,离子,激素和寄生虫的细胞反应性。
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公开(公告)号:US5187077A
公开(公告)日:1993-02-16
申请号:US294514
申请日:1988-12-09
申请人: David P. Gearing , Nicholas M. Gough , Douglas J. Hilton , Julie A. King , Donald Metcalf , Edouard C. Nice , Nicos A. Nicola , Richard J. Simpson , Tracy A. Willson
发明人: David P. Gearing , Nicholas M. Gough , Douglas J. Hilton , Julie A. King , Donald Metcalf , Edouard C. Nice , Nicos A. Nicola , Richard J. Simpson , Tracy A. Willson
IPC分类号: A61K38/00 , A61K49/00 , A61P35/02 , C07K1/18 , C07K1/20 , C07K1/22 , C07K4/12 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/54 , C12N1/16 , C12N1/19 , C12N1/20 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/14 , C12N15/19 , C12N15/81 , C12N15/867 , C12P21/02 , C12P21/06 , C12Q1/68 , C12R1/865 , C12R1/91 , G01N33/53
CPC分类号: C12N15/86 , C07K14/5415 , C12N15/81 , C12P21/02 , C12P21/06 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/23 , C07K2319/50 , C07K2319/74 , C07K2319/95 , C12N2740/13043
摘要: A leukaemia-inhibitory factor (LIF) is disclosed, together with a method of preparation of LIF in essentially pure form. Nucleotide and amino acid sequences are disclosed, together with recombinant DNA moleclues and host cells for production of polypeptides having LIF activity.
摘要翻译: 公开了白血病抑制因子(LIF),以及基本上纯粹形式制备LIF的方法。 公开了核苷酸和氨基酸序列以及用于产生具有LIF活性的多肽的重组DNA分子和宿主细胞。
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公开(公告)号:US07049418B2
公开(公告)日:2006-05-23
申请号:US09908805
申请日:2001-07-19
申请人: Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人: Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
IPC分类号: C07H17/00
CPC分类号: A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K2319/00 , C07K2319/43 , C07K2319/60 , C12N15/8509 , G01N33/6863
摘要: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译: 本发明一般涉及治疗和诊断剂。 更具体地,本发明提供能够调节信号转导的治疗分子,例如但不限于细胞因子介导的信号转导。 因此,本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子,抗原,微生物和微生物产物,病毒或其组分,离子,激素和寄生虫的细胞反应性。
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公开(公告)号:US06905842B1
公开(公告)日:2005-06-14
申请号:US08962560
申请日:1997-10-31
申请人: Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人: Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
IPC分类号: A61K38/00 , C07H21/04 , C07K14/47 , C12N15/09 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/564 , G01N33/574 , G01N33/68 , C21P21/06 , C14P14/00
CPC分类号: G01N33/564 , A61K38/00 , C07K14/4703 , G01N33/574 , G01N33/6863
摘要: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
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公开(公告)号:US5427925A
公开(公告)日:1995-06-27
申请号:US58979
申请日:1993-05-06
申请人: David P. Gearing , Nicholas M. Gough , Douglas J. Hilton , Julie A. King , Donald Metcalf , Edouard C. Nice , Nicos A. Nicola , Richard J. Simpson , Tracy A. Willson
发明人: David P. Gearing , Nicholas M. Gough , Douglas J. Hilton , Julie A. King , Donald Metcalf , Edouard C. Nice , Nicos A. Nicola , Richard J. Simpson , Tracy A. Willson
IPC分类号: A61K38/00 , A61K49/00 , A61P35/02 , C07K1/18 , C07K1/20 , C07K1/22 , C07K4/12 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/54 , C12N1/16 , C12N1/19 , C12N1/20 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/14 , C12N15/19 , C12N15/81 , C12N15/867 , C12P21/02 , C12P21/06 , C12Q1/68 , C12R1/865 , C12R1/91 , G01N33/53 , C12N1/21 , C12N15/85
CPC分类号: C12N15/86 , C07K14/5415 , C12N15/81 , C12P21/02 , C12P21/06 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/23 , C07K2319/50 , C07K2319/74 , C07K2319/95 , C12N2740/13043
摘要: The present invention provides a method for producing recombinant leukemia inhibitory factor (LIF) by the expression, in suitable host cells, of recombinant DNA molecules encoding LIF.
摘要翻译: 本发明提供了通过在合适的宿主细胞中表达编码LIF的重组DNA分子来产生重组白血病抑制因子(LIF)的方法。
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公开(公告)号:US06323317B1
公开(公告)日:2001-11-27
申请号:US09302769
申请日:1999-04-30
申请人: Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人: Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
IPC分类号: C07K100
CPC分类号: A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K2319/00 , C07K2319/43 , C07K2319/60 , C12N15/8509 , G01N33/6863
摘要: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译: 本发明一般涉及治疗和诊断剂。 更具体地,本发明提供能够调节信号转导的治疗分子,例如但不限于细胞因子介导的信号转导。 因此,本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子,抗原,微生物和微生物产物,病毒或其组分,离子,激素和寄生虫的细胞反应性。
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公开(公告)号:US5443825A
公开(公告)日:1995-08-22
申请号:US948614
申请日:1992-09-22
申请人: David P. Gearing , Nicholas M. Gough , Douglas J. Hilton , Julie A. King , Donald Metcalf , Edouard C. Nice , Nicos A. Nicola , Richard J. Simpson , Tracy A. Willson
发明人: David P. Gearing , Nicholas M. Gough , Douglas J. Hilton , Julie A. King , Donald Metcalf , Edouard C. Nice , Nicos A. Nicola , Richard J. Simpson , Tracy A. Willson
IPC分类号: A61K38/00 , A61K49/00 , A61P35/02 , C07K1/18 , C07K1/20 , C07K1/22 , C07K4/12 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/54 , C12N1/16 , C12N1/19 , C12N1/20 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/14 , C12N15/19 , C12N15/81 , C12N15/867 , C12P21/02 , C12P21/06 , C12Q1/68 , C12R1/865 , C12R1/91 , G01N33/53 , C07K9/00
CPC分类号: C12N15/86 , C07K14/5415 , C12N15/81 , C12P21/02 , C12P21/06 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/23 , C07K2319/50 , C07K2319/74 , C07K2319/95 , C12N2740/13043
摘要: Leukemia-inhibitory factor (LIF) has been produced in essentially pure form from murine or human sources. A method of purifying this LIF is disclosed, as well as polypeptides having LIF activity which are not identical in amino acid sequence to any naturally occurring form of LIF. The polypeptides can be used for hindering the proliferation of myeloid Leukemia cells.
摘要翻译: 白血病抑制因子(LIF)已经以基本纯粹的形式从鼠源或人源产生。 公开了纯化该LIF的方法,以及具有LIF活性的多肽,其氨基酸序列与任何天然存在的LIF形式不相同。 多肽可用于阻止骨髓性白血病细胞的增殖。
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公开(公告)号:US20080166730A1
公开(公告)日:2008-07-10
申请号:US11977132
申请日:2007-10-23
申请人: Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
发明人: Douglas J. Hilton , Warren S. Alexander , Elizabeth M. Viney , Tracy A. Willson , Rachael T. Richardson , Robyn Starr , Sandra E. Nicholson , Donald Metcalf , Nicos A. Nicola
IPC分类号: C12Q1/68
摘要: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.
摘要翻译: 本发明一般涉及治疗和诊断剂。 更具体地,本发明提供能够调节信号转导的治疗分子,例如但不限于细胞因子介导的信号转导。 因此,本发明的分子可用于调节对细胞因子以及信号转导的其它介质如内源性或外源性分子,抗原,微生物和微生物产物,病毒或其组分,离子,激素和寄生虫的细胞反应性。
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