公开(公告)号：US20230190713A1

公开(公告)日：2023-06-22

申请号：US17905629

申请日：2021-03-02

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  WUHAN UNIVERSITY

Inventor： Honglin LI ,  Ke XU ,  Shiliang LI ,  Lili ZHU ,  Zhenjiang ZHAO

IPC: A61K31/426 ,  A61P31/14 ,  A61P31/16 ,  A61K31/513 ,  A61K31/427 ,  A61K31/7056 ,  A61K31/675 ,  A61K31/215 ,  A61K31/351 ,  A61K31/19 ,  A61K31/4706

CPC classification number: A61K31/426 ,  A61K31/19 ,  A61K31/215 ,  A61K31/351 ,  A61K31/427 ,  A61K31/513 ,  A61K31/675 ,  A61K31/4706 ,  A61K31/7056 ,  A61P31/14 ,  A61P31/16

Abstract: An application of a novel thiazole derivative in the treatment of an RNA virus infection and the preparation of a drug for treating an RNA virus infection. Specifically, the present invention relates to a use of a compound represented by the following formula I and a pharmaceutical composition containing a compound represented by the following formula I in treating an RNA virus infection and preparing a drug for treating a coronavirus infection.

公开(公告)号：US20220098134A1

公开(公告)日：2022-03-31

申请号：US17424105

申请日：2020-06-12

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Honglin LI ,  Zhenjiang ZHAO ,  Rui WANG ,  Yinchu SHEN ,  Jianjun FU ,  Yufang XU ,  Xuhong QIAN ,  Qian JIAO ,  Shiliang LI

IPC: C07C33/26 ,  C07C43/23 ,  C07C49/82 ,  C07C33/30 ,  C07C69/16 ,  A61P9/12

Abstract: The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

公开(公告)号：US20170313715A1

公开(公告)日：2017-11-02

申请号：US15523058

申请日：2015-10-30

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Honglin LI ,  Hualiang JIANG ,  Yufang XU ,  Jia LI ,  Zhenjiang ZHAO ,  Jingya LI ,  Hongling XU ,  Shiliang LI

IPC: C07D493/04 ,  C07D311/92 ,  C07D311/60

Abstract: The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4.