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12 条记录 (耗时 0.025 秒)

    Pyrazolopyrimidine compounds and their use as PDE10 inhibitors
    1.
    发明授权
    Pyrazolopyrimidine compounds and their use as PDE10 inhibitors 有权
    吡唑并嘧啶化合物及其作为PDE10抑制剂的用途

    公开(公告)号：US08969376B2

    公开(公告)日：2015-03-03

    申请号：US13579095

    申请日：2011-02-25

    申请人： Eiji Kawanishi ,  Mitsuya Hongu ,  Yoshihito Tanaka

    发明人： Eiji Kawanishi ,  Mitsuya Hongu ,  Yoshihito Tanaka

    IPC分类号： A61K31/415 ,  C07D293/00 ,  C07D487/00 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： The present invention relates to a compound represented by formula [I]: wherein: R1 is hydrogen, halogen, lower alkyl or cyano; Ring A is an optionally substituted heterocyclic group; Ring B is an optionally substituted 3 to 6-membered monocyclic group; and Y is optionally substituted amino, optionally substituted cyclic amino, optionally substituted aliphatic 3 to 6-membered monocyclyloxy, optionally substituted lower alkyl or optionally substituted lower alkyl-O—, or a pharmaceutically acceptable salt thereof, and to their use as PDE10 inhibitor.

    摘要翻译： 本发明涉及由式[I]表示的化合物：其中：R 1是氢，卤素，低级烷基或氰基; 环A是任选取代的杂环基; 环B是任选取代的3至6元单环基团; 并且Y是任选取代的氨基，任选取代的环状氨基，任选取代的脂族3至6元单环氧基，任选取代的低级烷基或任选取代的低级烷基-O-或其药学上可接受的盐，以及它们作为PDE10抑制剂的用途。

    PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS
    2.
    发明申请
    PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS 有权
    吡唑并嘧啶化合物及其作为PDE10抑制剂的用途

    公开(公告)号：US20120309754A1

    公开(公告)日：2012-12-06

    申请号：US13579095

    申请日：2011-02-25

    申请人： Eiji Kawanishi ,  Mitsuya Hongu ,  Yoshihito Tanaka

    发明人： Eiji Kawanishi ,  Mitsuya Hongu ,  Yoshihito Tanaka

    IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P25/00 ,  A61P25/22 ,  A61P25/30 ,  A61K31/5377 ,  A61P25/18

    CPC分类号： C07D487/04

    摘要： The present invention relates to a compound represented by formula [I]: wherein: R1 is hydrogen, halogen, lower alkyl or cyano; Ring A is an optionally substituted heterocyclic group; Ring B is an optionally substituted 3 to 6-membered monocyclic group; and Y is optionally substituted amino, optionally substituted cyclic amino, optionally substituted aliphatic 3 to 6-membered monocyclyloxy, optionally substituted lower alkyl or optionally substituted lower alkyl-O—, or a pharmaceutically acceptable salt thereof, and to their use as PDE10 inhibitor.

    摘要翻译： 本发明涉及由式[I]表示的化合物：其中：R 1是氢，卤素，低级烷基或氰基; 环A是任选取代的杂环基; 环B是任选取代的3至6元单环基团; 并且Y是任选取代的氨基，任选取代的环状氨基，任选取代的脂族3至6元单环氧基，任选取代的低级烷基或任选取代的低级烷基-O-或其药学上可接受的盐，以及它们作为PDE10抑制剂的用途。

    Propiophenone derivative and a process for preparing the same
    7.
    发明授权
    Propiophenone derivative and a process for preparing the same 失效
    苯丙酮衍生物及其制备方法

    公开(公告)号：US5830873A

    公开(公告)日：1998-11-03

    申请号：US429567

    申请日：1995-04-27

    申请人： Kenji Tsujihara ,  Mitsuya Hongu ,  Nobuyuki Funami ,  Masanori Inamasu ,  Kenji Arakawa

    发明人： Kenji Tsujihara ,  Mitsuya Hongu ,  Nobuyuki Funami ,  Masanori Inamasu ,  Kenji Arakawa

    IPC分类号： C07H15/203 ,  C07H15/26 ,  A61K31/70 ,  C07K15/00

    CPC分类号： C07H15/203 ,  C07H15/26

    摘要： A propiophenone derivative of the formula �I!: ##STR1## wherein X is O, S or methylene, OY is a protected or unprotected OH, Z is .beta.-D-glucopyranosyl or 4-O-(.alpha.-D-glucopyranosyl)-.beta.-D-glucopyranosyl or wherein one or more hydroxy groups of these groups may optionally be acylated, and the dotted line means the presence or absence of a double bond, or a pharmaceutically acceptable salt thereof. Said compounds have excellent hypoglycemic activity so that they are useful in the prophylaxis or treatment of diabetes.

    摘要翻译： 式[I]的苯丙酮衍生物：其中X为O，S或亚甲基，OY为被保护或未被保护的OH，Z为β-D-吡喃葡萄糖基或4-O-（α-D- 吡喃葡萄糖基）-β-D-吡喃葡萄糖基或其中这些基团的一个或多个羟基可以任选地被酰化，并且虚线表示双键的存在或不存在或其药学上可接受的盐。 所述化合物具有优异的降血糖活性，因此它们可用于预防或治疗糖尿病。