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    Insulin expressing human pancreatic islet cell line capable of reversibly proliferating and use thereof
    1.
    发明申请
    Insulin expressing human pancreatic islet cell line capable of reversibly proliferating and use thereof 失效
    胰岛素表达人胰岛细胞系，其能够可逆地增殖并使用

    公开(公告)号：US20070086988A1

    公开(公告)日：2007-04-19

    申请号：US10578260

    申请日：2003-11-10

    申请人： Noriaki Tanaka ,  Naoya Kobayashi ,  Michiki Narushima ,  Yoshihito Tanaka

    发明人： Noriaki Tanaka ,  Naoya Kobayashi ,  Michiki Narushima ,  Yoshihito Tanaka

    IPC分类号： A61K48/00 ,  C12N5/08

    CPC分类号： C12N5/0676 ,  A61K35/12 ,  C12N2510/04

    摘要： A reversibly immortalized human pancreatic islet cell line containing an hTERT gene and an SV40T gene each interposed between a pair of LoxP sequences, characterized in that it is capable of producing insulin and enhancing expression of insulin after excising the hTERT gene and the SV40T gene, in particular, NAKT-13 (deposited with International Patent Organism Depository, National Institute of Advanced Industrial Science and Technology, address: AIST Tsukuba Central 6, 1-1, Higashi 1-Chome, Tsukuba-shi, Ibaraki-ken, 305-8566 Japan, deposited date: Sep. 4, 2003, accession number: FERM BP-08461) or a passage cell line thereof; a human pancreatic islet cell obtained by excising the hTERT gene and the SV40T gene from the reversibly immortalized human pancreatic islet cell line or passage cell line thereof; and use of these cells. By using the reversibly immortalized human pancreatic islet cell line of the invention insulin-producing cells can be easily and surely obtained in a number enough to meet the demand.

    摘要翻译： 一种含有hTERT基因和SV40T基因的可逆永生人胰岛细胞系，每个插入一对LoxP序列之间，其特征在于能够在切除hTERT基因和SV40T基因之后产生胰岛素并增强胰岛素的表达， 特别是NAKT-13（保藏于国立先进工业科学与技术研究所国际专利生物保藏中心，地址：日本茨城市茨城市筑波市东1町1-1-1筑波中央6-1号日本305-8566 ，保藏日期：2003年9月4日，登录号：FERM BP-08461）或其传代细胞系; 通过从可逆永生化人胰岛细胞系或其传代细胞系中切除hTERT基因和SV40T基因获得的人胰岛细胞; 并使用这些细胞。 通过使用本发明的可逆永生人胰岛细胞系，可以容易且可靠地获得足够数量的胰岛素产生细胞以满足需求。

    Process for manufacturing electrical contact pin
    3.
    发明授权
    Process for manufacturing electrical contact pin 失效
    电接触针制造工艺

    公开(公告)号：US4733465A

    公开(公告)日：1988-03-29

    申请号：US22783

    申请日：1987-03-06

    申请人： Yoshihito Tanaka

    发明人： Yoshihito Tanaka

    IPC分类号： H01R12/34 ,  H01R12/58 ,  H01R43/16

    CPC分类号： H01R43/16 ,  H01R12/585 ,  Y10T29/49204

    摘要： An electrical contact pin has a fixing part to be fitted into a through hole of a circuit board for fixing without using any solder. The fixing part has a substantially rectangular cross section. A pair of alternating recesses are provided on opposite sides of said rectangular section. A pair of corners closer to said recesses extend beyond said sides to form a pair of projected corners. A process for manufacturing such an electrical contact pin is characterized by the step of pressing a metal work having a substantially rectangular cross section to form said fixing part in a pair of metal dies. A pair of projections are provided on the bottoms of said dies to form said recesses. A pair of opposite sides of said dies are arranged so that there may be small spaces between said pair of sides and the opposite sides of said work before pressed. A part of said bottom of each die is made deeper than the rest of said bottom so as to form said projected corner when said work is squeezed.

    摘要翻译： 电接触销具有固定部分，以将其装配到电路板的通孔中，用于固定，而不使用任何焊料。 固定部分具有大致矩形的截面。 一对交替的凹槽设置在所述矩形部分的相对侧上。 靠近所述凹部的一对角部延伸超过所述侧面以形成一对突出的角。 用于制造这种电接触针的方法的特征在于：按压具有大致矩形横截面的金属制件以在一对金属模具中形成所述固定部分的步骤。 在所述模具的底部设置有一对凸起以形成所述凹部。 所述模具的一对相对侧被布置成使得在压制之前所述工件的所述一对侧面和相对侧之间可以具有小的空间。 每个模具的所述底部的一部分比所述底部的其余部分更深，以便当所述工件被挤压时形成所述突出的角部。

    PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS
    4.
    发明申请
    PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS 有权
    吡唑并嘧啶化合物及其作为PDE10抑制剂的用途

    公开(公告)号：US20120309754A1

    公开(公告)日：2012-12-06

    申请号：US13579095

    申请日：2011-02-25

    申请人： Eiji Kawanishi ,  Mitsuya Hongu ,  Yoshihito Tanaka

    发明人： Eiji Kawanishi ,  Mitsuya Hongu ,  Yoshihito Tanaka

    IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P25/00 ,  A61P25/22 ,  A61P25/30 ,  A61K31/5377 ,  A61P25/18

    CPC分类号： C07D487/04

    摘要： The present invention relates to a compound represented by formula [I]: wherein: R1 is hydrogen, halogen, lower alkyl or cyano; Ring A is an optionally substituted heterocyclic group; Ring B is an optionally substituted 3 to 6-membered monocyclic group; and Y is optionally substituted amino, optionally substituted cyclic amino, optionally substituted aliphatic 3 to 6-membered monocyclyloxy, optionally substituted lower alkyl or optionally substituted lower alkyl-O—, or a pharmaceutically acceptable salt thereof, and to their use as PDE10 inhibitor.

    摘要翻译： 本发明涉及由式[I]表示的化合物：其中：R 1是氢，卤素，低级烷基或氰基; 环A是任选取代的杂环基; 环B是任选取代的3至6元单环基团; 并且Y是任选取代的氨基，任选取代的环状氨基，任选取代的脂族3至6元单环氧基，任选取代的低级烷基或任选取代的低级烷基-O-或其药学上可接受的盐，以及它们作为PDE10抑制剂的用途。

    Insulin expressing human pancreatic islet cell line capable of reversibly proliferating and use thereof
    7.
    发明授权
    Insulin expressing human pancreatic islet cell line capable of reversibly proliferating and use thereof 失效
    胰岛素表达人胰岛细胞系，其能够可逆地增殖并使用

    公开(公告)号：US07629168B2

    公开(公告)日：2009-12-08

    申请号：US10578260

    申请日：2003-11-10

    申请人： Noriaki Tanaka ,  Naoya Kobayashi ,  Michiki Narushima ,  Yoshihito Tanaka

    发明人： Noriaki Tanaka ,  Naoya Kobayashi ,  Michiki Narushima ,  Yoshihito Tanaka

    IPC分类号： C12P5/06 ,  C12P21/06 ,  C12P21/04 ,  A61K48/00

    CPC分类号： C12N5/0676 ,  A61K35/12 ,  C12N2510/04

    摘要： A reversibly immortalized human pancreatic islet cell line containing an hTERT gene and an SV40T gene each interposed between a pair of LoxP sequences, characterized in that it is capable of producing insulin and enhancing expression of insulin after excising the hTERT gene and the SV40T gene, in particular, NAKT-13 (deposited with International Patent Organism Depository, National Institute of Advanced Industrial Science and Technology, address: AIST Tsukuba Central 6, 1-1, Higashi 1-Chome, Tsukuba-shi, Ibaraki-ken, 305-8566 Japan, deposited date: Sep. 4, 2003, accession number: FERM BP-08461) or a passage cell line thereof; a human pancreatic islet cell obtained by excising the hTERT gene and the SV40T gene from the reversibly immortalized human pancreatic islet cell line or passage cell line thereof; and use of these cells. By using the reversibly immortalized human pancreatic islet cell line of the invention insulin-producing cells can be easily and surely obtained in a number enough to meet the demand.

    摘要翻译： 一种含有hTERT基因和SV40T基因的可逆永生人胰岛细胞系，每个插入一对LoxP序列之间，其特征在于能够在切除hTERT基因和SV40T基因之后产生胰岛素并增强胰岛素的表达， 特别是NAKT-13（保藏于国立先进工业科学与技术研究所国际专利生物保藏中心，地址：日本茨城市茨城市筑波市东1町1-1-1筑波中央6-1号日本305-8566 ，保藏日期：2003年9月4日，登录号：FERM BP-08461）或其传代细胞系; 通过从可逆永生化人胰岛细胞系或其传代细胞系中切除hTERT基因和SV40T基因获得的人胰岛细胞; 并使用这些细胞。 通过使用本发明的可逆永生人胰岛细胞系，可以容易且可靠地获得足够数量的胰岛素产生细胞以满足需求。

    Method and apparatus for displaying an image
    8.
    发明授权
    Method and apparatus for displaying an image 失效
    用于显示图像的方法和装置

    公开(公告)号：US06633291B1

    公开(公告)日：2003-10-14

    申请号：US09516208

    申请日：2000-02-29

    申请人： Hirofumi Sugitani ,  Yoshihito Tanaka ,  Masaaki Yoshikawa ,  Satoshi Ohtake ,  Noritsune Sekiguchi

    发明人： Hirofumi Sugitani ,  Yoshihito Tanaka ,  Masaaki Yoshikawa ,  Satoshi Ohtake ,  Noritsune Sekiguchi

    IPC分类号： G06T1510

    CPC分类号： G06T15/10 ,  G06T17/00

    摘要： A three-dimensional shape model indicating a first part is constructed and a three-dimensional shape that works as a transparent screen is disposed thereon continuously. A sight line direction is set and the three-dimensional shape model is displayed after rotated in accordance with the set sight line direction. A first two-dimensional image is constructed in accordance with the sight line direction, and a second two-dimensional image is constructed. The first two-dimensional image and the second two-dimensional image are combined with each other so as to construct a combined two-dimensional image. The combined two-dimensional image is assigned so that the part thereof corresponding to the first two-dimensional image agrees with the three-dimensional shape model, and the combined two-dimensional image is displayed visually.

    摘要翻译： 构成表示第一部分的三维形状模型，并且连续地设置作为透明屏幕的三维形状。 设置视线方向，并且根据设定的视线方向旋转后显示三维形状模型。 根据视线方向构造第一二维图像，构造第二二维图像。 将第一二维图像和第二二维图像相互组合，以构成组合的二维图像。 分配组合的二维图像，使得其对应于第一二维图像的部分与三维形状模型一致，并且组合的二维图像被目视显示。

    Salt of morpholine compound
    9.
    发明授权
    Salt of morpholine compound 有权
    吗啉化合物盐

    公开(公告)号：US08030303B2

    公开(公告)日：2011-10-04

    申请号：US12309196

    申请日：2007-07-11

    申请人： Katsuhiko Masuda ,  Shuzo Takeda ,  Yoshihito Tanaka

    发明人： Katsuhiko Masuda ,  Shuzo Takeda ,  Yoshihito Tanaka

    IPC分类号： A61K31/535 ,  C07D417/12

    CPC分类号： C07D417/12

    摘要： (2S)-[4-(Carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide and a crystal thereof, which resist easy weight change caused by vapor sorption as compared to a free form, and are superior as drug substances of pharmaceutical products, and a production intermediate therefor are provided.

    摘要翻译： （2S） - [4-（羧甲基）噻唑-2-基硫代] -N - {[4-（3,4-二氯苄基）吗啉-2-基]甲基}乙酰胺氢溴酸盐及其结晶， 与游离形式相比，由蒸汽吸附引起，作为药物的药物，优选为其制造中间体。

    Pyrazolopyrimidine compounds and their use as PDE10 inhibitors
    10.
    发明授权
    Pyrazolopyrimidine compounds and their use as PDE10 inhibitors 有权
    吡唑并嘧啶化合物及其作为PDE10抑制剂的用途

    公开(公告)号：US08969376B2

    公开(公告)日：2015-03-03

    申请号：US13579095

    申请日：2011-02-25

    申请人： Eiji Kawanishi ,  Mitsuya Hongu ,  Yoshihito Tanaka

    发明人： Eiji Kawanishi ,  Mitsuya Hongu ,  Yoshihito Tanaka

    IPC分类号： A61K31/415 ,  C07D293/00 ,  C07D487/00 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： The present invention relates to a compound represented by formula [I]: wherein: R1 is hydrogen, halogen, lower alkyl or cyano; Ring A is an optionally substituted heterocyclic group; Ring B is an optionally substituted 3 to 6-membered monocyclic group; and Y is optionally substituted amino, optionally substituted cyclic amino, optionally substituted aliphatic 3 to 6-membered monocyclyloxy, optionally substituted lower alkyl or optionally substituted lower alkyl-O—, or a pharmaceutically acceptable salt thereof, and to their use as PDE10 inhibitor.

    摘要翻译： 本发明涉及由式[I]表示的化合物：其中：R 1是氢，卤素，低级烷基或氰基; 环A是任选取代的杂环基; 环B是任选取代的3至6元单环基团; 并且Y是任选取代的氨基，任选取代的环状氨基，任选取代的脂族3至6元单环氧基，任选取代的低级烷基或任选取代的低级烷基-O-或其药学上可接受的盐，以及它们作为PDE10抑制剂的用途。