Process for the preparation of 2,3-pyridinedicarboxylic acids
    4.
    发明授权
    Process for the preparation of 2,3-pyridinedicarboxylic acids 失效
    2,3-吡啶二羧酸的制备方法

    公开(公告)号:US06395903B1

    公开(公告)日:2002-05-28

    申请号:US09569057

    申请日:2000-05-10

    IPC分类号: C07D21380

    CPC分类号: C07D213/80

    摘要: Process for the preparation of pure 2,3-pyridinedicarboxylic acids of the formula I which are substituted in position 4 and/or 5 and/or 6 by R1, where R1 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkoxy-C1-C4 alkyl, halogen, hydroxyl or nitro, from quinolines of the formula II in which R1 is as defined above, and which are substituted in position 6 and/or 7 by R2, where R2 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkoxy-C1-C4 alkyl, halogen, hydroxyl, nitro or amino, which are reacted in the first step in aqueous sulfuric acid or nitric acid solution with ozone in the ratio of from 1:2 to 1:3 at temperatures from 0 to +50° C., and the resulting peroxide solution is then reacted at temperatures of from +0 to +100° C. in the presence of 0.5-4.0 mol of oxidizing agent per mole of ozonolysis product formed, after which the pH of the reaction solution is adjusted to 0.2 to 3, the mixture is cooled to 0 to 30° C., and the precipitated pyridinedicarboxylic acid is isolated.

    摘要翻译: 制备式Ⅰ的纯的2,3-吡啶二羧酸的方法,其中R1是氢,C1-C4烷基,C1-C4烷氧基,C1-C4烷基, 烷氧基-C 1 -C 4烷基,卤素,羟基或硝基,其中R 1如上定义,并且其中R 2为氢,C 1 -C 4烷基,C 1 -C 4烷基, C 1 -C 4烷氧基,C 1 -C 4烷氧基-C 1 -C 4烷基,卤素,羟基,硝基或氨基,它们在第一步中在硫酸水溶液或硝酸溶液中与臭氧按1:2比1反应 :3,在0至+ 50℃的温度下,然后将所得过氧化物溶液在+ 0至+ 100℃的温度下在每摩尔臭氧分解产物0.5-4.0摩尔氧化剂存在下反应 之后,将反应溶液的pH调节至0.2〜3,将混合物冷却至0〜30℃,分离析出的吡啶二甲酸。

    Electromagnetic relay
    6.
    发明授权
    Electromagnetic relay 失效
    电磁继电器

    公开(公告)号:US5894254A

    公开(公告)日:1999-04-13

    申请号:US61523

    申请日:1998-04-16

    摘要: A relay is formed by a magnet system containing a wound coil body, an L-shaped core arranged axially therein, an L-shaped armature and a base element with terminal elements. Stationary and moving contact elements are arranged between the base element and the magnet system. The armature is mounted with the free end of its transverse leg at the free end of the longitudinal leg of the core. The armature is secured through a U-shaped armature spring wrapping around the armature. The spring is secured with one arm at the longitudinal leg of the armature and a second arm is inserted in a recess between the coil body and the core. The actuation of the moving contact elements is provided via a slide coupled to the armature. This slide is hooked to the armature by spring tabs of the armature spring at opposing sides of the armature through snap latches formed at the ends of the side arms of the slide.

    摘要翻译: 继电器由包含卷绕的线圈体的磁体系统,其轴向设置的L形磁芯,L形电枢和具有端子元件的基座元件形成。 固定和移动的接触元件布置在基座元件和磁体系统之间。 电枢安装在其横向腿的自由端处于芯的纵向腿部的自由端。 电枢通过缠绕在电枢上的U形电枢弹簧固定。 弹簧在电枢的纵向腿处用一个臂固定,并且第二臂插入在线圈体和芯之间的凹部中。 通过联接到电枢的滑块来提供可动接触元件的致动。 该滑块通过电枢弹簧在电枢的相对侧的弹簧片钩住电枢,通过形成在滑块的侧臂的端部处的卡扣闩锁。

    Eye examination apparatus employing polarized light probe
    8.
    发明授权
    Eye examination apparatus employing polarized light probe 失效
    使用偏振光探针的眼科检查仪

    公开(公告)号:US5787890A

    公开(公告)日:1998-08-04

    申请号:US229151

    申请日:1994-04-18

    IPC分类号: A61B3/10 A61B3/12 A61B3/14

    CPC分类号: A61B3/1225

    摘要: Apparatus is provided for determining the topography, thickness, and fiber orientation of the nerve fiber layer at the fundus of the eye by measuring the polarization shift induced in a return beam of polarized light which is reflected at the ocular fundus from an incident beam of a known polarization state. A corneal polarization compensator effectively cancels the birefringent effects of the cornea and other portions of the eye anterior to the fundus, so that clinically meaningful results are produced.

    摘要翻译: 提供了一种设备,用于通过测量在从眼睛的眼底反射的偏振光的反射光束中感应的偏振偏移,从而检测眼睛的眼底处的神经纤维层的形貌,厚度和纤维取向 已知的极化状态。 角膜偏振补偿器有效地抵消了角膜和眼睛其他部位在眼底前方的双折射效应,从而产生临床上有意义的结果。

    Retinal eye disease diagnostic system
    9.
    发明授权
    Retinal eye disease diagnostic system 失效
    视网膜疾病诊断系统

    公开(公告)号:US5303709A

    公开(公告)日:1994-04-19

    申请号:US808479

    申请日:1991-12-16

    CPC分类号: A61B3/1225

    摘要: Means and Method are provided for determining both the topography and the thickness of the nerve fiber layer at the fundus of the eye by measuring the polarization shift of the reflected probing light. The technique is greatly enhanced in the accuracy of its results by the utilization of a corneal polarization compensator, which lies at the heart of the invention.

    摘要翻译: 提供了通过测量反射的探测光的偏振偏移来确定眼睛眼底的神经纤维层的形貌和厚度的手段和方法。 通过使用位于本发明的核心的角膜偏振补偿器,其结果的精度大大提高。

    Process for preparing high-purity, halogen-free o-phthaladehyde
    10.
    发明授权
    Process for preparing high-purity, halogen-free o-phthaladehyde 有权
    制备高纯度无卤素邻苯二甲醛的方法

    公开(公告)号:US07858381B2

    公开(公告)日:2010-12-28

    申请号:US11475086

    申请日:2006-06-27

    IPC分类号: G01N33/00

    摘要: Improved process for preparing high-purity, halogen-free o-phthalaldehyde, in which a) tetrahalo-o-xylene is hydrolyzed at a temperature of 155-160° C. and a pressure of from 2 to 5 bar, where appropriate in the presence of a phase-transfer catalyst, to o-phthalaldehyde, which b) is converted in an acidic alcoholic solution at a temperature of from 0 to the reflux temperature into the corresponding dialkoxyphthalane and, subsequently, c) an acetal cleavage is effected by acid hydrolysis at a pH >1.5 to pH 7, resulting in high-purity, halogen-free o-phthalaldehyde.

    摘要翻译: 改进的制备高纯度无卤邻苯二甲醛的方法,其中a)四卤代邻二甲苯在155-160℃的温度和2至5巴的压力下水解, 相转移催化剂存在于邻苯二甲醛中,b)在酸性醇溶液中在0至回流温度下转化成相应的二烷氧基苯烷,然后c)通过酸进行缩醛裂解 在pH> 1.5至pH7下水解,得到高纯度,无卤素的邻苯二甲醛。