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    PROCESS FOR PREPARING A DIAMINE/DICARBOXYLIC ACID SALT
    1.
    发明申请
    PROCESS FOR PREPARING A DIAMINE/DICARBOXYLIC ACID SALT 有权
    制备二胺/二羧酸盐的方法

    公开(公告)号：US20150361028A1

    公开(公告)日：2015-12-17

    申请号：US14234248

    申请日：2012-07-26

    申请人： Eric Grolman ,  Rudy Rulkens

    发明人： Eric Grolman ,  Rudy Rulkens

    IPC分类号： C07C209/68 ,  C07C51/41 ,  C07C211/12 ,  C07C55/20 ,  C07C211/09 ,  C07C63/28 ,  C07C55/14

    CPC分类号： C07C209/68 ,  C07B2200/13 ,  C07C51/412 ,  C07C55/14 ,  C07C55/20 ,  C07C63/28 ,  C07C211/09 ,  C07C211/12 ,  C08G69/04 ,  C08G69/265 ,  C07C63/24 ,  C07C63/26 ,  C07C63/36

    摘要： The present invention also relates to a process for preparing a diamine/dicarboxylic acid salt wherein the dicarboxylic acid comprises an aromatic dicarboxylic acid and is provided in a powder form; the diamine is provided in a liquid form gradually dosed to the dicarboxylic acid powder, while keeping the dicarboxylic acid powder in constant movement; the processing temperature is above 0° C. and below the boiling temperature of the diamine and the melting temperature of the acid and the salt, and the reaction mixture comprises at most 5 wt. % of water. The present invention also relates to an anhydrous diamine/dicarboxylic acid salt obtainable by the process according to invention, or any embodiment thereof as described above.

    摘要翻译： 本发明还涉及一种制备二胺/二羧酸盐的方法，其中二羧酸包括芳族二羧酸并以粉末形式提供; 二胺以逐渐递送到二羧酸粉末的液体形式提供，同时保持二羧酸粉末恒定运动; 处理温度高于0℃，低于二胺的沸点温度和酸和盐的熔融温度，反应混合物至多为5重量％。 ％的水。 本发明还涉及通过本发明的方法获得的无水二胺/二羧酸盐或其如上所述的任何实施方案。

    Complexes Comprising alpha2-Adrenergic Receptor Agonists and Compositions
    3.
    发明申请
    Complexes Comprising alpha2-Adrenergic Receptor Agonists and Compositions 审中-公开
    包含α2-肾上腺素能受体激动剂和组合物的复合物

    公开(公告)号：US20080293728A1

    公开(公告)日：2008-11-27

    申请号：US12121083

    申请日：2008-05-15

    申请人： Gregory L. McIntire ,  Stephen R. Davio ,  Arthur E. Harms ,  Hongna Wang

    发明人： Gregory L. McIntire ,  Stephen R. Davio ,  Arthur E. Harms ,  Hongna Wang

    IPC分类号： A61K31/498 ,  C07D403/12 ,  C07C55/20 ,  C07C57/03 ,  C07C65/10 ,  A61P25/00 ,  C07C65/05 ,  C07C229/36 ,  C07C61/29

    CPC分类号： C07D403/12 ,  C07D498/04

    摘要： A complex comprises at least an α2-adrenergic receptor agonist and a compound that provides an opposite charge to a charge on the α2-adrenergic receptor agonist, wherein the complex is charge neutral as a whole and has a solubility in a range from about 0.3 μg/ml to about 2.5 mg/ml in water at pH of about 7 and temperature of about 25° C. The complex is included in a composition, device, or implant for use in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system.

    摘要翻译： 复合物包含至少一种α2-肾上腺素能受体激动剂和向α2-肾上腺素能受体激动剂上的电荷提供相反电荷的化合物，其中该络合物作为整体为电荷中性，并且在约0.3μm的范围内具有溶解度 / ml至约2.5mg / ml，pH约7，温度约25℃。该复合物包含在组合物，装置或植入物中，用于神经保护神经组织的组分以防止进行性退化 的这些组件。 特别地，这样的组合物，装置或植入物可用于向视神经系统的细胞和组分提供神经保护。

    Method for preparing cleaved products from castor oil or derivatives thereof
    7.
    发明授权
    Method for preparing cleaved products from castor oil or derivatives thereof 失效
    从蓖麻油或其衍生物制备裂解产物的方法

    公开(公告)号：US5952517A

    公开(公告)日：1999-09-14

    申请号：US800416

    申请日：1997-02-14

    申请人： Charles David Ries ,  Thomas Samuel Totah

    发明人： Charles David Ries ,  Thomas Samuel Totah

    IPC分类号： C07C27/00 ,  C07C29/00 ,  C07C31/125 ,  C07C45/00 ,  C07C45/27 ,  C07C45/78 ,  C07C49/04 ,  C07C51/16 ,  C07C51/295 ,  C07C55/20 ,  C07B33/00

    CPC分类号： C07C45/78 ,  C07C45/27 ,  C07C51/295

    摘要： A process for producing a cleaved product from castor oil, or derivatives thereof, by high temperature caustic oxidation reaction accomplished by combining at least one chemically inert heat transfer fluid, a catalyst, and an alkali in aqueous solution to form a first mixture wherein the diluent is present in an amount sufficient to reduce foaming and solidification of the mixture while increasing the yield and improving the purity and adding a ricinic compound to the first mixture to form a second mixture. The temperature of the second mixture is raised to a level sufficient to conduct pyrolysis, and the cleaved product produced thereby is recovered by adding an acid to the reaction mixture in an amount sufficient to acidify the reaction mixture down below a pH of about 6. The invention further relates to the reaction mixture used to produce the cleaved products. The present invention provides higher product yields and purer cleaved products produced by the oxidation of castor oil or its derivatives than conventionally obtained.

    摘要翻译： 通过将至少一种化学惰性的传热流体，催化剂和碱在水溶液中组合以形成第一混合物，通过高温苛性氧化反应从蓖麻油或其衍生物生产裂解产物的方法，以形成第一混合物，其中稀释剂 以足以减少混合物发泡和凝固的量存在，同时提高产量并提高纯度，并向第一混合物中加入蓖麻毒素以形成第二混合物。 将第二混合物的温度升高至足以进行热解的水平，通过向反应混合物中加入足以将反应混合物酸化至低于约6的pH的量来回收由此产生的裂解产物。 本发明还涉及用于产生裂解产物的反应混合物。 本发明通过蓖麻油或其衍生物的氧化产生的较高的产率和较纯的裂解产物比传统获得的产物更高。

    Process for the purification of 1,10-decanedicarboxylic acid
    9.
    发明授权
    Process for the purification of 1,10-decanedicarboxylic acid 失效
    1,10-癸烷二羧酸纯化方法

    公开(公告)号：US4067779A

    公开(公告)日：1978-01-10

    申请号：US572857

    申请日：1975-04-29

    申请人： Ferdinand List ,  Otto Rauhut ,  Peter Hegenberg ,  Rudolf Strobele

    发明人： Ferdinand List ,  Otto Rauhut ,  Peter Hegenberg ,  Rudolf Strobele

    IPC分类号： C07C55/20 ,  C07C51/00 ,  C07C51/487 ,  C07C55/02 ,  C07C55/21 ,  C07C67/00 ,  C08L63/02 ,  B01D3/10

    CPC分类号： C07C51/487 ,  C08L63/00

    摘要： Crude 1,10-decanedicarboxylic acid produced by the nitric acid oxidation at 20.degree.14 60.degree. C. of cyclododecanone, cyclododecanol or a mixture thereof can be purified by distillation to a purity suitable for use in the production of polyamides and polyesters by reducing prior to distillation, e.g., by heating to 70.degree.-90.degree. C., the organically bound nitrogen content and as required the nitric acid content, e.g., by washing, and water content thereof so that the sample which is distilled has maximum contents thereof of 0.05%, 0.02% and 0.1% by weight, respectively, and distilling the pre-purified sample at a sump temperature of 215.degree.-225.degree. C. and at a pressure of 0.5 - 2 torr.

    摘要翻译： 可以通过蒸馏纯化20d14℃的环十二酮，环十二烷醇或其混合物的硝酸氧化产生的粗制1,10-癸烷二羧酸，其纯度适用于通过还原先前的方法生产聚酰胺和聚酯 进行蒸馏，例如通过加热至70-90℃，有机结合的氮含量和硝酸含量，例如通过洗涤及其含水量，使得蒸馏的样品的最大含量为 分别为0.05％，0.02％和0.1％，并在215-225℃的贮槽温度和0.5-2托的压力下蒸馏预纯化的样品。

    Reaction of acetic acid derivatives with ethylene
    10.
    发明授权
    Reaction of acetic acid derivatives with ethylene 失效
    乙酸衍生物与乙烯的反应

    公开(公告)号：US3687988A

    公开(公告)日：1972-08-29

    申请号：US3687988D

    申请日：1970-11-18

    申请人： MOBIL OIL CORP

    发明人： CHEN ALBERT C ,  BUTTER STEPHEN A ,  HOBSON RICHARD W

    IPC分类号： C07C51/353 ,  C07C53/126 ,  C07C55/02 ,  C07C55/10 ,  C07C55/14 ,  C07C55/20 ,  C07C55/21 ,  C07C53/00 ,  C07C57/00

    CPC分类号： C07C55/10 ,  C07C51/353 ,  C07C53/126 ,  C07C55/02 ,  C07C55/14 ,  C07C55/20 ,  C07C55/21 ,  Y02P20/584

    摘要： This specification discloses a process of reacting an acetic acid derivative with ethylene in the presence of a catalyst. The acetic acid derivatives include esters, the amide, substituted amides, and the anhydride of acetic acid. The catalyst is insoluble in the acetic acid derivatives, the ethylene, and the reaction products thereof and is an oxide of manganese wherein the manganese has a valence at least as great as 3. The catalyst, following the reaction, can be separated from the reaction mixture and regenerated by heating in the presence of an oxygencontaining gas. Thereafter, the regenerated catalyst may be employed further for the reaction of an acetic acid derivative with ethylene.

    摘要翻译： 本说明书公开了在催化剂存在下使乙酸衍生物与乙烯反应的方法。 乙酸衍生物包括酯，酰胺，取代的酰胺和乙酸的酸酐。 催化剂不溶于乙酸衍生物，乙烯及其反应产物，并且是锰的氧化物，其中锰的价数至少为3。反应后​​的催化剂可以与反应物分离 混合物，并在含氧气体存在下加热再生。 此后，再生催化剂可以进一步用于乙酸衍生物与乙烯的反应。