摘要:
A printer system stores a trace of a printer job in storage that is either local or accessible to the printer system. A remotely implemented tool accesses the stored printer job trace. The tool includes a graphical interface that displays the printer commands in the printer job trace in a human readable format. The commands may be displayed in a first window of the interface. In one embodiment, the interface includes a second window where details of a command selected or highlighted in the first window are displayed. The tool may be implemented as a secure web browser that requires password verification to access the printer job trace. The tool may include the ability to replace confidential print data with generic or non-confidential data. The tool might further be able to display text that is embedded in a printer job trace command in ASCII and EBCDIC format.
摘要:
A method for providing a predictive out status of a printer is disclosed. The method comprises determining a media requirement of a job for the printer, determining that the proper amount of the media is within the printer, and determining if the job can be printed at the printer based upon the media requirement and the proper amount of media within the printer. In a second aspect, a method in a printer network is disclosed. The method comprises determining if a job can be printed in a default printer. The method further comprises querying all other printers in the network to determine if the job can be printed, if the job can not be printed at the default printer. The method then allows for printing the job at one of the other printers if the job can be printed at the one printer. In a system and method in accordance with the present invention, a predictive message is posted that the printer does not have sufficient paper to complete the task. The advantage to using this approach is posting a very specific error as to the printer's situation and then in enough time to stop the error before it occurs.
摘要:
A print controller, methods, and software are disclosed. A print controller of the invention includes applications, a parameter manager, and a notification system. The applications register with parameter manager those parameters for which they want to be notified when a change occurs. As part of the registration, the applications designate a callback identifier (CID) for each of the parameters, where an individual CID may be associated with a single parameter or a plurality of related parameters. Responsive to receiving an indication of changes to one or more of the parameters, the notification system identifies the applications registered to be notified of changes to the parameters, and identifies the CIDs associated with the parameters that have changed. The notification system then transmits one or more notification messages, including the identified CIDs for the changed parameters, to each application that is registered.
摘要:
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
摘要:
The invention relates to bicyclic heterocycles of formulae I and II with anti-cancer and/or anti-inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要:
Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring fused to the benzoxepin ring, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要:
Benzoxepin compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; and where (i) X1 is N and X2 is S, (ii) X1 is S and X2 is N, (iii) X1 is CR7 and X2 is S, (iv) X1 is S and X2 is CR7; (v) X1 is NR8 and X2 is N, (vi) X1 is N and X2 is NR8, (vii) X1 is CR7 and X2 is O, (viii) X1 is O and X2 is CR7, (ix) X1 is CR7 and X2 is C(R7)2, (x) X1 is C(R7)2 and X2 is CR7; (xi) X1 is N and X2 is O, or (xii) X1 is O and X2 is N, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要:
The invention relates to imidazopyridines of formula I with anti-cancer and/or anti-inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要:
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
摘要:
Thienopyrimidines of formula (Ia) or (Ib): wherein R1-R3 have any of the values described herein, and the pharmaceutically acceptable salt thereof have activity as inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase, in particular the p110 delta subtype, such as immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.