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公开(公告)号：US07919603B2
公开(公告)日：2011-04-05
申请号：US11612156
申请日：2006-12-18
申请人： Evgeny A. Nudler , Ilya Shamovsky
发明人： Evgeny A. Nudler , Ilya Shamovsky
CPC分类号： C12N15/113 , C07K14/4705 , C12N15/11 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2330/10 , C12N2500/46 , C12Q1/6886 , C12Q2600/136
摘要： The present invention provides a novel RNA, designated herein as the “HSR1” (Heat Shock RNA), and its use together with translation elongation factor eEF1A in activation of heat shock transcription factor HSF. The invention further provides the use of HSR1 for generation of novel therapeutics for the treatment of cancer, inflammation, ischemia, neurodegeneration, age-related diseases, HIV infection, deafness, and related disorders.
摘要翻译： 本发明提供了本文中称为“HSR1”（Heat Shock RNA）的新型RNA及其与翻译延伸因子eEF1A在激活热休克转录因子HSF中的用途。 本发明还提供HSR1用于产生用于治疗癌症，炎症，缺血，神经变性，年龄相关疾病，HIV感染，耳聋和相关疾病的新型治疗剂的用途。
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2.发明申请HEAT SHOCK RNA FROM VARIOUS SPECIES AND ITS USE IN ACTIVATION OF HEAT SHOCK TRANSCRIPTION FACTOR, IN TREATMENT OF VARIOUS DISEASES IN ANIMALS AND IN GENERATION OF STRESS-RESISTANT PLANTS 有权来自不同物种的热冲击RNA及其在激活热休克转录因子中的用途，用于治疗动物中各种疾病和产生抗耐药植物公开(公告)号：US20090188009A1
公开(公告)日：2009-07-23
申请号：US12263140
申请日：2008-10-31
申请人： Evgeny A. Nudler , Ilya Shamovsky
发明人： Evgeny A. Nudler , Ilya Shamovsky
CPC分类号： C12N15/8218 , C07K14/4705 , C12N15/11 , C12N15/113 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2330/10 , C12N2500/46 , C12Q1/6886 , C12Q2600/136
摘要： The present invention provides a novel RNA, designated herein as the “HSR1” (Heat Shock RNA), and its use together with translation elongation factor eEF1A in activation of heat shock transcription factor HSF. The invention further provides the use of HSR1 for generation of novel therapeutics for the treatment of various diseases in animals and for generation of stress-resistant plants.
摘要翻译： 本发明提供了本文中称为“HSR1”（Heat Shock RNA）的新型RNA及其与翻译延伸因子eEF1A在激活热休克转录因子HSF中的用途。 本发明还提供HSR1用于产生用于治疗动物中各种疾病和产生抗胁迫植物的新型治疗剂。
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公开(公告)号：US08889850B2
公开(公告)日：2014-11-18
申请号：US13272920
申请日：2011-10-13
申请人： Evgeny A. Nudler , Ilya Shamovsky
发明人： Evgeny A. Nudler , Ilya Shamovsky
CPC分类号： C12N15/8218 , C07K14/4705 , C12N15/11 , C12N15/113 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2330/10 , C12N2500/46 , C12Q1/6886 , C12Q2600/136
摘要： The present invention is directed to molecules that inhibit expression or a function of a eukaryotic Heat Shock RNA (HSR1) and their use for inhibiting a stress response or stress tolerance in a cell.
摘要翻译： 本发明涉及抑制真核热休克RNA（HSR1）的表达或功能的分子及其在细胞中抑制应激反应或应激耐受性的用途。
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4.发明申请HEAT SHOCK RNA FROM VARIOUS SPECIES AND ITS USE IN ACTIVATION OF HEAT SHOCK TRANSCRIPTION FACTOR, IN TREATMENT OF VARIOUS DISEASES IN ANIMALS AND IN GENERATION OF STRESS-RESISTANT PLANTS 有权来自不同物种的热冲击RNA及其在激活热休克转录因子中的用途，用于治疗动物中各种疾病和产生抗耐药植物公开(公告)号：US20120142100A1
公开(公告)日：2012-06-07
申请号：US13272920
申请日：2011-10-13
申请人： Evgeny A. Nudler , Ilya Shamovsky
发明人： Evgeny A. Nudler , Ilya Shamovsky
CPC分类号： C12N15/8218 , C07K14/4705 , C12N15/11 , C12N15/113 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2330/10 , C12N2500/46 , C12Q1/6886 , C12Q2600/136
摘要： The present invention provides a novel RNA, designated herein as the “HSR1” (Heat Shock RNA), and its use together with translation elongation factor eEF1A in activation of heat shock transcription factor HSF. The invention further provides the use of HSR1 for generation of novel therapeutics for the treatment of various diseases in animals and for generation of stress-resistant plants.
摘要翻译： 本发明提供了本文中称为“HSR1”（Heat Shock RNA）的新型RNA及其与翻译延伸因子eEF1A在激活热休克转录因子HSF中的用途。 本发明还提供HSR1用于产生用于治疗动物中各种疾病和产生抗胁迫植物的新型治疗剂。
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公开(公告)号：US08067558B2
公开(公告)日：2011-11-29
申请号：US12263140
申请日：2008-10-31
申请人： Evgeny A. Nudler , Ilya Shamovsky
发明人： Evgeny A. Nudler , Ilya Shamovsky
CPC分类号： C12N15/8218 , C07K14/4705 , C12N15/11 , C12N15/113 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2330/10 , C12N2500/46 , C12Q1/6886 , C12Q2600/136
摘要： The present invention provides a novel RNA, designated herein as the “HSR1” (Heat Shock RNA), constitutively active HSR1 fragments, and the use of HSR1 and constitutively active HSR1 fragments for generation of novel therapeutics for the treatment of various diseases in animals and for generation of stress-resistant plants.
摘要翻译： 本发明提供了一种本文中称为“HSR1”（热休克RNA），组成型活性HSR1片段的新型RNA，以及使用HSR1和组成型活性HSR1片段产生用于治疗动物中各种疾病的新型治疗剂， 用于产生抗应力植物。
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6.发明申请HEAT SHOCK RNA AND ITS USE IN ACTIVATION OF HEAT SHOCK TRANSCRIPTION FACTOR AND TREATMENT OF CANCER, INFLAMMATION, ISCHEMIA, NEURODEGENERATION, AGE-RELATED DISEASES, HIV INFECTION, DEAFNESS, AND RELATED DISORDERS 有权热休克RNA及其在热休克转录因子的激活中的应用和癌症，炎症，ISCHEMIA，神经细胞增生，年龄相关疾病，艾滋病毒感染，DEAFNESS和相关疾病的治疗公开(公告)号：US20070238682A1
公开(公告)日：2007-10-11
申请号：US11612156
申请日：2006-12-18
申请人： Evgeny Nudler , Ilya Shamovsky
发明人： Evgeny Nudler , Ilya Shamovsky
IPC分类号： A61K31/7052 , C12N15/00 , C12N15/11 , C12N5/10 , C12Q1/68
CPC分类号： C12N15/113 , C07K14/4705 , C12N15/11 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2330/10 , C12N2500/46 , C12Q1/6886 , C12Q2600/136
摘要： The present invention provides a novel RNA, designated herein as the “HSR1” (Heat Shock RNA), and its use together with translation elongation factor eEF1A in activation of heat shock transcription factor HSF. The invention further provides the use of HSR1 for generation of novel therapeutics for the treatment of cancer, inflammation, ischemia, neurodegeneration, age-related diseases, HIV infection, deafness, and related disorders.
摘要翻译： 本发明提供了本文中称为“HSR1”（Heat Shock RNA）的新型RNA及其与翻译延伸因子eEF1A在激活热休克转录因子HSF中的用途。 本发明还提供HSR1用于产生用于治疗癌症，炎症，缺血，神经变性，年龄相关疾病，HIV感染，耳聋和相关疾病的新型治疗剂的用途。
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