公开(公告)号：US20220283170A1

公开(公告)日：2022-09-08

申请号：US17742378

申请日：2022-05-11

Applicant: FUJIFILM Corporation

Inventor： Kousuke WATANABE ,  Yoshinori KANAZAWA ,  Ryo FUJIWARA ,  Kenji SHIROKANE ,  Hiroaki TANAKA ,  Yuki ARAI ,  Kazuoki KOMIYAMA

IPC: G01N33/58 ,  C09K11/06 ,  C09B23/01 ,  C09B23/06 ,  C09B23/10

Abstract: Provided are any one of the following compounds and a fluorescently labeled biological substance having this compound. R1 to R27, L11, L12, and X+ represent a specific group, and at least one of R1 to R4 represents a substituted alkyl group.
In a case where at least one of R1 to R4 is an alkyl group having a carboxy group or a substituent capable of being bonded to a biological substance, at least one of R11 to R27 is an alkyl group or an aryl group, or at least one of R1 to R4, which does not correspond to the alkyl group having a carboxy group or an alkyl group having a substituent capable of being bonded to a biological substance, is an alkyl group having a sulfoalkyl group through a single bond or a linking group.
The total of n1 to n4 is an integer of 3 or more, and m=n1+n2+n3+n4−1 is satisfied.
At least one of R1 to R4, R13, L11 or L12 in Formula (1) and at least one of R1 to R4, R24, L11, or L12 in Formula (2) have a specific substituent.

公开(公告)号：US20230159547A1

公开(公告)日：2023-05-25

申请号：US18069982

申请日：2022-12-21

Applicant: FUJIFILM Corporation

Inventor： Yoshinori KANAZAWA ,  Ryo FUJIWARA ,  Kazuoki KOMIYAMA

IPC: C07D487/14

CPC classification number: C07D487/14

Abstract: There are provided a compound of Formula (1) and a labeled biological substance having the compound.




R1 to R6, R11 to R13, and R22 to R29 represent specific groups, and n is an integer of 1 to 3.
One selected from R1, R2, R5, R22 to R25 and one selected from R3, R4, R6, and R26 to R29 are bonded through a linking group LL.
The linking group LL represents a linking group having 1 to 100 atoms, which does not have any one of an aromatic hydrocarbon ring, a sulfo group, or a phosphono group.
R1, . . . , R6, R22, . . . , or R29 includes a structure represented by —(CH2—CH2—O)m—, where m is 1 to 50.
The above-described compound is a neutral compound and contains at least one substituent capable of being bonded to a carboxy group or a biological substance.

公开(公告)号：US20250011851A1

公开(公告)日：2025-01-09

申请号：US18893975

申请日：2024-09-24

Applicant: FUJIFILM CORPORATION

Inventor： Takeshi HAMA ,  Daisuke ETO ,  Hiroyasu ISHII ,  Naoto ISOZAKI ,  Kazuoki KOMIYAMA

IPC: C12Q1/6844 ,  B01L3/00 ,  B01L7/00

Abstract: A test container, in which a sample solution is fed from a first chamber to a second chamber in order by a centrifugal force, includes: a liquid reservoir portion that stores the sample solution; a valve that includes a liquid storage portion temporarily storing the sample solution to be fed from the first chamber to the second chamber and is capable of switching between a first state where the first chamber and the liquid storage portion communicate with each other, a second state where the second chamber and the liquid storage portion communicate with each other, and a third state where both of the first chamber and the second chamber do not communicate with the liquid storage portion; and a sealing part that prevents a back flow of the sample solution after the sample solution is fed from the liquid reservoir portion to the first chamber.

公开(公告)号：US20250010298A1

公开(公告)日：2025-01-09

申请号：US18893976

申请日：2024-09-24

Applicant: FUJIFILM CORPORATION

Inventor： Takeshi HAMA ,  Daisuke ETO ,  Hiroyasu ISHII ,  Naoto ISOZAKI ,  Kazuoki KOMIYAMA

IPC: B01L3/00

Abstract: A test container, in which a sample solution is transferred from a first chamber to a second chamber in order by a centrifugal, includes a liquid reservoir portion that stores the sample solution in front of the first chamber, and a valve that includes a liquid storage portion temporarily storing the sample solution to be fed from the first chamber to the second chamber, in which a volume of the liquid reservoir portion is larger than a volume of the first chamber, the first chamber and the liquid reservoir portion are connected to each other only by a liquid flow channel through which the sample solution is fed, the first chamber and the second chamber are connected to each other only by a liquid flow channel through which a sample solution is fed, and a vent flow channel through which gas is released from the first chamber is not provided.

公开(公告)号：US20230219932A1

公开(公告)日：2023-07-13

申请号：US18048426

申请日：2022-10-20

Applicant: FUJIFILM Corporation

Inventor： Yoshinori KANAZAWA ,  Ryo FUJIWARA ,  Kenji SHIROKANE ,  Kousuke WATANABE ,  Yuki ARAI ,  Kazuoki KOMIYAMA ,  Hiroaki TANAKA

IPC: C07D403/08 ,  C07D471/04

CPC classification number: C07D403/08 ,  C07D471/04

Abstract: There are provided a compound of Formula (1) and a labeled biological substance having the compound.





Z1 and Z2 represent a specific 6-membered ring. However, at least one of Z1 or Z2 is a benzene ring having a specific substituent at an ortho position with respect to a nitrogen atom to which L1 or L2 is bonded, or a specific nitrogen-containing 6-membered ring in which a ring-constituting atom located at the ortho position is a nitrogen atom.
R1 to R4, R11 to R13, L1, L2, and R21 represents specific groups, and n, α1, α2, and m represent specific numbers.
The compound has at least one structure represented by —(CH2—CH2—O)m-R21 on a heterocyclic ring and has at least one substituent capable of being bonded to a carboxy group or a biological substance at a specific position, and in a case where at least one of Z1 or Z2 is the specific nitrogen-containing 6-membered ring, the specific substituents may be bonded to each other to form a ring.

公开(公告)号：US20130119278A1

公开(公告)日：2013-05-16

申请号：US13672373

申请日：2012-11-08

Applicant: FUJIFILM CORPORATION

Inventor： Takahiko MIZUSAWA ,  Hiromi ISHIKAWA ,  Kazuoki KOMIYAMA ,  Tomoki INOUE

IPC: G21K5/10

CPC classification number: G01T1/2016

Abstract: A radiographic image erasing device includes: a first light source that applies first erase light including a wavelength in the ultraviolet region to a storage phosphor sheet in which a radiographic image has been stored and recorded; a second light source that is placed at a height identical to that of the first light source and applies second erase light including a wavelength of a longer wavelength than that of the first erase light to the storage phosphor sheet to which the first erase light has been applied; drive mechanisms that switch the orientations or positions of the first light source and the second light source; and a controller that controls the drive mechanisms in accordance with a conveyance direction of the storage phosphor sheet such that the first erase light and the second erase light are applied in this order to the storage phosphor sheet.

Abstract translation: 放射线图像擦除装置包括：第一光源，其将包括紫外区域中的波长的第一擦除光施加到已经存储和记录放射线照相图像的存储磷光体片; 放置在与第一光源的高度相同的高度的第二光源，并且将包括比第一擦除光的波长更长的波长的第二擦除光施加到已经具有第一擦除光的存储磷光体片 应用; 驱动机构，其切换第一光源和第二光源的取向或位置; 以及控制器，其根据存储荧光体片的输送方向控制驱动机构，使得第一擦除光和第二擦除光依次被施加到存储荧光体片。