公开(公告)号：US12285525B2

公开(公告)日：2025-04-29

申请号：US17112239

申请日：2020-12-04

Applicant: FUJIFILM Corporation

Inventor： Shintaro Tanabe ,  Masahiko Yamamoto ,  Kimihiko Sato ,  Motomasa Takahashi ,  Kazuhiro Tsuna ,  Yasutaka Tasaki ,  Taisuke Endo ,  Issei Doi ,  Hirofumi Fukunaga

IPC: A61K9/127 ,  A61K9/1272 ,  A61K9/1278 ,  C07C219/06 ,  C12N15/88

Abstract: An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, X represents —NR1— or —O—, R1 represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.

公开(公告)号：US20230295202A1

公开(公告)日：2023-09-21

申请号：US18296151

申请日：2023-04-05

Applicant: FUJIFILM Corporation

Inventor： Hidenobu KUNIYOSHI ,  Takehiro Yamane ,  Takayuki Yamakawa ,  Shintaro Tanabe ,  Hideyasu Fujiwara ,  Eiichi Kodama

IPC: C07F9/6561 ,  A61K31/683 ,  A61P31/20

CPC classification number: C07F9/65616 ,  A61K31/683 ,  A61P31/20

Abstract: An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides a compound represented by General Formula [1]
(in the formula, R1 represents a halogen atom, an amino group which may be substituted, a C1-6 alkoxy group which may be substituted, a hydroxyl group which may be protected, or the like; R2 represents a hydrogen atom or an amino protecting group; R3 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; R4 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like); or a salt thereof.

公开(公告)号：US20210147456A1

公开(公告)日：2021-05-20

申请号：US17158520

申请日：2021-01-26

Applicant: FUJIFILM Corporation

Inventor： Hidenobu KUNIYOSHI ,  Takehiro Yamane ,  Takayuki Yamakawa ,  Shintaro Tanabe ,  Hideyasu Fujiwara ,  Eiichi Kodama

IPC: C07F9/6561

Abstract: An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides a compound represented by General Formula [1] (in the formula, R1 represents a halogen atom, an amino group which may be substituted, a C1-6 alkoxy group which may be substituted, a hydroxyl group which may be protected, or the like; R2 represents a hydrogen atom or an amino protecting group; R3 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; R4 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like); or a salt thereof.

公开(公告)号：US12202850B2

公开(公告)日：2025-01-21

申请号：US18296151

申请日：2023-04-05

Applicant: FUJIFILM Corporation

Inventor： Hidenobu Kuniyoshi ,  Takehiro Yamane ,  Takayuki Yamakawa ,  Shintaro Tanabe ,  Hideyasu Fujiwara ,  Eiichi Kodama

IPC: A61K31/683 ,  A61P31/20 ,  C07F9/6561

Abstract: An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides a compound represented by General Formula [1] (in the formula, R1 represents a halogen atom, an amino group which may be substituted, a C1-6 alkoxy group which may be substituted, a hydroxyl group which may be protected, or the like; R2 represents a hydrogen atom or an amino protecting group; R3 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; R4 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like); or a salt thereof.

公开(公告)号：US20250017858A1

公开(公告)日：2025-01-16

申请号：US18884577

申请日：2024-09-13

Applicant: FUJIFILM Corporation

Inventor： Noriyuki Kasagi ,  Masashi Yoshimura ,  Keiko Makita ,  Shintaro Tanabe ,  Tatsuya Nitabaru

IPC: A61K9/127 ,  A61K31/7088 ,  C12N15/88

Abstract: An object of the present invention is to provide a lipid composition capable of realizing an excellent nucleic acid delivery efficiency. According to the present invention, there is provided a lipid composition containing a compound represented by Formula (1), a lipid represented by Formula (2) or a salt of the lipid, a neutral lipid, a nonionic hydrophilic polymer, and a lipid having a nucleic acid. The definition of each symbol in the formulae is as described in the present specification.

公开(公告)号：US09783536B2

公开(公告)日：2017-10-10

申请号：US14795568

申请日：2015-07-09

Applicant: FUJIFILM Corporation

Inventor： Hidetomo Furuyama ,  Hideki Kurihara ,  Takahiro Terao ,  Daisuke Nakagawa ,  Shintaro Tanabe ,  Takayuki Kato ,  Masahiko Yamamoto ,  Shinichiro Sekine ,  Tomoyuki Mashiko ,  Shinsuke Inuki ,  Satoshi Ueda

IPC: C07D519/00 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: A compound represented by Formula [1](in the formula, Z1 represents N, CH, or the like; X1 represents NH or the like; R1 represents a heteroaryl group or the like; each of R2, R3, and R4 represents a hydrogen atom, a halogen atom, an alkoxy group, or the like; and R5 represents a heteroaryl group or the like) or salt thereof.