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公开(公告)号：US20160339451A1
公开(公告)日：2016-11-24
申请号：US15035711
申请日：2014-12-17
CPC分类号： B04B11/02 , A61M1/0272 , A61M1/3692 , A61M1/3696 , B04B5/0442 , B04B9/10
摘要： The invention relates to a device for processing an initial liquid medium (4) comprising cells in an initial concentration in order to obtain a product liquid medium (4′) comprising cells in a product concentration, the device (2) comprising a separator (6) adapted to separate the initial liquid medium (4) into various constituents, a first supply system (8) for supplying the initial liquid medium (4) to the separator (6), a first outlet system (12) for extracting the product liquid medium (4′) from the separator (6), a sensor (22, 22′) adapted to measure a physical parameter related to the concentration of the cells in the initial or product liquid medium (4, 4′), and a control unit (24) coupled to the sensor (22, 22′) and adapted to control at least one process of the device (2) as a function of the physical parameter measured by the sensor (22, 22′). The device is characterized by a second supply system (10) for supplying a solution (18) to the separator (6) with a given flow rate. The flow rate of the solution (18) in the second supply system (10) during its supply to the separator (6) is determined based on the at least one process parameter.
摘要翻译： 本发明涉及一种用于处理初始液体介质（4）的装置，其中初始液体介质（4）包含初始浓度的单元，以便获得包含产品浓度的单元的产品液体介质（4'），该装置（2）包括分离器 ）适于将初始液体介质（4）分离成各种组分，用于将初始液体介质（4）供应到分离器（6）的第一供应系统（8），用于提取产物液体的第一出口系统（12） 来自分离器（6）的介质（4'），适于测量与初始或产品液体介质（4,4'）中的细胞浓度相关的物理参数的传感器（22,22'），以及控制 单元（24），其耦合到所述传感器（22,22'），并且适于根据由所述传感器（22,22'）测量的物理参数来控制所述设备（2）的至少一个过程。 该装置的特征在于用于以给定的流量将溶液（18）供应到分离器（6）的第二供应系统（10）。 基于至少一个工艺参数来确定第二供应系统（10）在供应到分离器（6）期间的溶液（18）的流量。
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公开(公告)号：US10022732B2
公开(公告)日：2018-07-17
申请号：US15035711
申请日：2014-12-17
摘要： The invention relates to a device for processing an initial liquid medium (4) comprising cells in an initial concentration in order to obtain a product liquid medium (4′) comprising cells in a product concentration, the device (2) comprising a separator (6) adapted to separate the initial liquid medium (4) into various constituents, a first supply system (8) for supplying the initial liquid medium (4) to the separator (6), a first outlet system (12) for extracting the product liquid medium (4′) from the separator (6), a sensor (22, 22′) adapted to measure a physical parameter related to the concentration of the cells in the initial or product liquid medium (4, 4′), and a control unit (24) coupled to the sensor (22, 22′) and adapted to control at least one process of the device (2) as a function of the physical parameter measured by the sensor (22, 22′). The device is characterized by a second supply system (10) for supplying a solution (18) to the separator (6) with a given flow rate. The flow rate of the solution (18) in the second supply system (10) during its supply to the separator (6) is determined based on the at least one process parameter.
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公开(公告)号：US20190167889A1
公开(公告)日：2019-06-06
申请号：US16324178
申请日：2017-08-17
摘要： The present invention relates to a method for separating lymphocytes and/or stem cells from whole blood in an automated blood separation system, wherein the quality of the collected lymphocytes and/or stem cells fractions is increased and the cell collection procedure is further automated by use of an optical sensor comprised in a detector device to measure turbidity and colour in the claimed method and in a cell separator, which can be used to perform the claimed method. The method of the invention is particularly useful to collect lymphocytes and/or stem cells fractions from whole blood, wherein the contamination of the collected cell fractions by platelets, red blood cells and granulocytes is reduced.
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公开(公告)号：US20180333419A1
公开(公告)日：2018-11-22
申请号：US16028636
申请日：2018-07-06
IPC分类号： A61K31/53 , C07D413/10 , A61K45/06 , C07D403/04 , C07D417/04 , C07D253/075 , C07D405/10 , C07D403/10 , C07D413/04
CPC分类号： A61K31/53 , A61K45/06 , A61M1/0272 , A61M1/3692 , A61M1/3696 , B04B5/0442 , B04B9/10 , B04B11/02 , C07D253/075 , C07D403/04 , C07D403/10 , C07D405/10 , C07D413/04 , C07D413/10 , C07D417/04
摘要： A method for processing an initial liquid medium including cells in an initial concentration to obtain a product liquid medium including cells in a product concentration includes supplying the initial medium to a separator via a first supply system, separating the initial medium into various constituents including the product medium, extracting the product medium from the separator via a first outlet system, measuring a physical parameter related to the concentration of the cells in the initial medium using a sensor, and controlling at least one process parameter as a function of the physical parameter. During the step of separating the initial medium, a solution is supplied to the separator at a flow rate via a second supply system. The flow rate of the solution is determined based on the at least one process parameter, and is reduced when the concentration of the cells measured in the initial medium increases.
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