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1.发明授权公开(公告)号：US09409187B2
公开(公告)日：2016-08-09
申请号：US14421543
申请日：2013-08-14
发明人： Artur Meisberger , Ilka Sternheimer
CPC分类号： B04B9/08 , B01D21/26 , B04B5/0442 , B04B2005/0492 , B04B2009/085
摘要： A centrifuge device comprises a fixed section, a drive device having a drive shaft, and a rotor mounted on the fixed section about a first rotational axis. The rotor is drivable about the first rotational axis. A transfer shaft is mounted on the rotor about a second rotational axis eccentric to the first rotational axis, the transfer shaft being coupled via a gearing with the fixed section. A centrifugal chamber is rotatable about a third rotational axis and is operatively connected to the transfer shaft. A locking device is arranged on the rotor for axially fixing the centrifugal chamber on the rotor. The locking device comprises a locking element and an actuating element, the locking element being adjustable between a locked position in which the centrifugal chamber is axially fixed with respect to the rotor and an unlocked position in which the centrifugal chamber is removable from the rotor.
摘要翻译： 离心机装置包括固定部分，具有驱动轴的驱动装置和围绕第一旋转轴线安装在固定部分上的转子。 转子围绕第一旋转轴可驱动。 传动轴围绕偏心于第一旋转轴线的第二旋转轴线安装在转子上，传送轴通过齿轮与固定部分联接。 离心室可围绕第三旋转轴线旋转并且可操作地连接到传送轴。 转子上设有锁定装置，用于将离心室轴向固定在转子上。 锁定装置包括锁定元件和致动元件，锁定元件可在离心室相对于转子轴向固定的锁定位置和离心室从转子移除的解锁位置之间调节。
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公开(公告)号：US10111992B2
公开(公告)日：2018-10-30
申请号：US15112926
申请日：2014-12-17
IPC分类号： A61M1/02 , A61M1/36 , G01F23/292
摘要： Disclosed is an apparatus and method for determining the liquid level of salvaged blood in a blood collection reservoir (11) of an autologous blood transfusion system (20), comprising sensing means (10, 12) for periodically sensing the liquid level of the salvaged blood in said blood collection reservoir (11) and outputting corresponding signals, and determining means (2) for determining the liquid level of the salvaged blood in said blood collection reservoir (11) based on said output signal of said sensing means. The sensing means comprises a plurality of light emitters (12) disposed on a first side of said blood collection reservoir (11) at different height levels (L1-L9) for emitting light and a plurality of light receivers (10) disposed at said different height levels (L1-L9) on a second side of said blood collection reservoir (11) opposite to said first side for sensing light emitted by said light emitters (12) and transmitted through said blood collection reservoir (11). Parameters of the optical set-up used for detection and signal analysis may be adjusted individually and dynamically so that disturbing effects caused e.g. by absorptive films on the inner surface of the blood collection reservoir (11) may be identified and prevented to thereby enhance the reliability of signal detection and analysis.
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公开(公告)号：US10022732B2
公开(公告)日：2018-07-17
申请号：US15035711
申请日：2014-12-17
摘要： The invention relates to a device for processing an initial liquid medium (4) comprising cells in an initial concentration in order to obtain a product liquid medium (4′) comprising cells in a product concentration, the device (2) comprising a separator (6) adapted to separate the initial liquid medium (4) into various constituents, a first supply system (8) for supplying the initial liquid medium (4) to the separator (6), a first outlet system (12) for extracting the product liquid medium (4′) from the separator (6), a sensor (22, 22′) adapted to measure a physical parameter related to the concentration of the cells in the initial or product liquid medium (4, 4′), and a control unit (24) coupled to the sensor (22, 22′) and adapted to control at least one process of the device (2) as a function of the physical parameter measured by the sensor (22, 22′). The device is characterized by a second supply system (10) for supplying a solution (18) to the separator (6) with a given flow rate. The flow rate of the solution (18) in the second supply system (10) during its supply to the separator (6) is determined based on the at least one process parameter.
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公开(公告)号：US20170227438A1
公开(公告)日：2017-08-10
申请号：US15503152
申请日：2015-08-03
发明人： Frank Schmidt , Ilka Sternheimer , Artur Meisberger , Lars Michel
CPC分类号： G01N15/05 , A61B5/14535 , A61B5/4836 , A61B2560/0437 , A61M1/0209 , A61M1/0259 , A61M1/0281 , A61M1/36 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3632 , A61M1/3692 , A61M1/3693 , A61M2205/12 , A61M2205/121 , A61M2205/3313 , A61M2205/3368 , A61M2205/3375 , A61M2209/086 , A61M2230/207 , B01L3/502 , B01L2200/025 , B01L2300/0609 , B01L2300/0627 , B01L2300/0848 , B01L2300/0851 , G01N29/024 , G01N29/222 , G01N29/223 , G01N2015/0065 , G01N2015/0073 , G01N2015/0092 , G01N2015/055 , G01N2291/02466 , G01N2291/044
摘要： A blood processing apparatus (1) comprises a measurement device (8) having at least one chamber element (80, 81) for receiving a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L), a bottom wall (803, 813) and a top wall (805, 815) together defining a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The blood processing apparatus (1) further comprises a holder device (9) for holding the measurement device (8), the holder device (9) comprising a base (90) having a reception opening (900) for receiving the measurement device (8) and a closure element (91) movably arranged on the base (90) for locking the measurement device (8) in an inserted position in the reception opening (900). An ultrasonic sensor element (92, 93) of the holder device (9) is arranged on the base (90) and adapted to produce an ultrasonic sensor signal (P) for measuring a haematocrit value of a blood fluid in the flow chamber (802, 812). Herein, the ultrasonic sensor element (92, 93), in the inserted position of the measurement device (8), faces the bottom wall (803, 813) of the at least one chamber element (80, 81) for transmitting the ultrasonic signal (P) into the flow chamber (802, 812) through the bottom wall (803, 813). In this way a blood processing apparatus comprising a holder device for a measurement device is provided which allows to easily insert the measurement device into the holder device and allows for a reliable measurement of, in particular, a haematocrit value of a blood flow through the measurement device.
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公开(公告)号：US10653345B2
公开(公告)日：2020-05-19
申请号：US15503152
申请日：2015-08-03
发明人： Frank Schmidt , Ilka Sternheimer , Artur Meisberger , Lars Michel
IPC分类号： A61B5/145 , A61M1/02 , A61M1/36 , G01N29/024 , G01N29/22 , B01L3/00 , G01N15/05 , A61B5/00 , G01N15/00
摘要： A blood processing apparatus includes a measurement device having at least one chamber element extending along a longitudinal axis and including a circumferential wall extending about the longitudinal axis, a bottom wall and a top wall together defining a flow chamber. The blood processing apparatus further includes a holder for the measurement device, the holder including a base having a reception opening for receiving the measurement device and a closure element movably arranged on the base for locking the measurement device in an inserted position in the reception opening. An ultrasonic sensor of the holder is arranged on the base. The ultrasonic sensor, in the inserted position of the measurement device, faces the bottom wall of the at least one chamber element, wherein the bottom wall extends transversely with respect to the longitudinal axis.
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公开(公告)号：US10279097B2
公开(公告)日：2019-05-07
申请号：US15503124
申请日：2015-08-03
摘要： A blood processing apparatus (1) comprises a measurement device (8) having a first chamber element (80) for measuring a haematocrit value of a blood fluid, the first chamber element (80) comprising a first inlet port (800) connectable to a first reservoir container (2) for allowing a flow from the first reservoir container (2) into the first chamber element (80) and a first outlet port (801) for allowing a flow out of the first chamber element (80), and the second chamber element (81) comprising a second inlet port (810) for allowing a flow into the second chamber element (81) and a second outlet port (811) connectable to a second reservoir container (3) for allowing a flow out of the second chamber element (81) towards the second reservoir container (3). The blood processing apparatus furthermore comprises a first pump mechanism (600) for pumping a blood fluid in a flow direction (F1) from the first reservoir container (2) towards the blood processing apparatus (1), and a second pump mechanism (610) for pumping a blood fluid in a flow direction (F2) from the blood processing apparatus (1) towards the second reservoir container (2). Herein, the first pump mechanism (600) is located upstream of the first inlet port (800) of the first chamber element (80) and the second pump mechanism (610) is located upstream of the second inlet port (810) of the second chamber element (81). In this way a blood processing apparatus comprising a measurement device is provided which in an easy and reliable manner allows for a measurement of in particular a haematocrit value in the incoming blood flow as well as the outgoing blood flow.
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公开(公告)号：US20150231649A1
公开(公告)日：2015-08-20
申请号：US14421543
申请日：2013-08-14
发明人： Artur Meisberger , Ilka Sternheimer
CPC分类号： B04B9/08 , B01D21/26 , B04B5/0442 , B04B2005/0492 , B04B2009/085
摘要： A centrifuge device comprises a fixed section, a drive device having a drive shaft, and a rotor mounted on the fixed section about a first rotational axis. The rotor is drivable about the first rotational axis. A transfer shaft is mounted on the rotor about a second rotational axis eccentric to the first rotational axis, the transfer shaft being coupled via a gearing with the fixed section. A centrifugal chamber is rotatable about a third rotational axis and is operatively connected to the transfer shaft. A locking device is arranged on the rotor for axially fixing the centrifugal chamber on the rotor. The locking device comprises a locking element and an actuating element, the locking element being adjustable between a locked position in which the centrifugal chamber is axially fixed with respect to the rotor and an unlocked position in which the centrifugal chamber is removable from the rotor.
摘要翻译： 离心机装置包括固定部分，具有驱动轴的驱动装置和围绕第一旋转轴线安装在固定部分上的转子。 转子围绕第一旋转轴可驱动。 传动轴围绕偏心于第一旋转轴线的第二旋转轴线安装在转子上，传送轴通过齿轮与固定部分联接。 离心室可围绕第三旋转轴线旋转并且可操作地连接到传送轴。 转子上设有锁定装置，用于将离心室轴向固定在转子上。 锁定装置包括锁定元件和致动元件，锁定元件可在离心室相对于转子轴向固定的锁定位置和离心室从转子移除的解锁位置之间调节。
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公开(公告)号：US10589008B2
公开(公告)日：2020-03-17
申请号：US15503136
申请日：2015-08-03
摘要： A tubing set for use in a blood processing apparatus comprises a measurement device (8) having at least one chamber element (80, 81) for measuring a haematocrit value of a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L) and encompassing a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The tubing set furthermore comprises an inlet-side tube section (21, 31) connected to the inlet port (800, 810) and an outlet-side tube section (22, 30) connected to the outlet port (801, 811). Herein, the inlet port (800, 810) and the outlet port (801, 811) are arranged on the circumferential wall (804, 814) and are displaced with respect to each other along the longitudinal axis (L). In this way a tubing set comprising a measurement device is provided which in an easy and reliable manner allows for the measuring of a haematocrit value of a blood fluid.
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公开(公告)号：US20170224893A1
公开(公告)日：2017-08-10
申请号：US15503136
申请日：2015-08-03
CPC分类号： A61M1/0209 , A61B5/14535 , A61M1/0259 , A61M1/0281 , A61M1/36 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3632 , A61M1/3692 , A61M1/3693 , A61M39/00 , A61M2205/12 , A61M2205/121 , A61M2205/3375 , A61M2209/086 , A61M2230/207 , G01N29/024 , G01N29/222 , G01N33/49 , G01N33/4915 , G01N2291/02466
摘要： A tubing set for use in a blood processing apparatus comprises a measurement device (8) having at least one chamber element (80, 81) for measuring a haematocrit value of a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L) and encompassing a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The tubing set furthermore comprises an inlet-side tube section (21, 31) connected to the inlet port (800, 810) and an outlet-side tube section (22, 30) connected to the outlet port (801, 811). Herein, the inlet port (800, 810) and the outlet port (801, 811) are arranged on the circumferential wall (804, 814) and are displaced with respect to each other along the longitudinal axis (L). In this way a tubing set comprising a measurement device is provided which in an easy and reliable manner allows for the measuring of a haematocrit value of a blood fluid.
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公开(公告)号：US20160339451A1
公开(公告)日：2016-11-24
申请号：US15035711
申请日：2014-12-17
CPC分类号： B04B11/02 , A61M1/0272 , A61M1/3692 , A61M1/3696 , B04B5/0442 , B04B9/10
摘要： The invention relates to a device for processing an initial liquid medium (4) comprising cells in an initial concentration in order to obtain a product liquid medium (4′) comprising cells in a product concentration, the device (2) comprising a separator (6) adapted to separate the initial liquid medium (4) into various constituents, a first supply system (8) for supplying the initial liquid medium (4) to the separator (6), a first outlet system (12) for extracting the product liquid medium (4′) from the separator (6), a sensor (22, 22′) adapted to measure a physical parameter related to the concentration of the cells in the initial or product liquid medium (4, 4′), and a control unit (24) coupled to the sensor (22, 22′) and adapted to control at least one process of the device (2) as a function of the physical parameter measured by the sensor (22, 22′). The device is characterized by a second supply system (10) for supplying a solution (18) to the separator (6) with a given flow rate. The flow rate of the solution (18) in the second supply system (10) during its supply to the separator (6) is determined based on the at least one process parameter.
摘要翻译： 本发明涉及一种用于处理初始液体介质（4）的装置，其中初始液体介质（4）包含初始浓度的单元，以便获得包含产品浓度的单元的产品液体介质（4'），该装置（2）包括分离器 ）适于将初始液体介质（4）分离成各种组分，用于将初始液体介质（4）供应到分离器（6）的第一供应系统（8），用于提取产物液体的第一出口系统（12） 来自分离器（6）的介质（4'），适于测量与初始或产品液体介质（4,4'）中的细胞浓度相关的物理参数的传感器（22,22'），以及控制 单元（24），其耦合到所述传感器（22,22'），并且适于根据由所述传感器（22,22'）测量的物理参数来控制所述设备（2）的至少一个过程。 该装置的特征在于用于以给定的流量将溶液（18）供应到分离器（6）的第二供应系统（10）。 基于至少一个工艺参数来确定第二供应系统（10）在供应到分离器（6）期间的溶液（18）的流量。
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