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143 条记录 (耗时 0.04 秒)

    Derivatives of benzofuran or benzodioxazole compounds
    5.
    发明授权
    Derivatives of benzofuran or benzodioxazole compounds 失效
    苯并呋喃或苯并恶唑化合物的衍生物

    公开(公告)号：US06716987B1

    公开(公告)日：2004-04-06

    申请号：US10023091

    申请日：2001-12-20

    申请人： Etsuo Ohshima ,  Takashi Kawakita ,  Koji Yanagawa ,  Kyoichiro Iida ,  Rie Koike ,  Yoshisuke Nakasato ,  Tohru Matsuzaki ,  Kenji Ohmori ,  Soichiro Sato ,  Hidee Ishii ,  Haruhiko Manabe ,  Michio Ichimura ,  Fumio Suzuki

    发明人： Etsuo Ohshima ,  Takashi Kawakita ,  Koji Yanagawa ,  Kyoichiro Iida ,  Rie Koike ,  Yoshisuke Nakasato ,  Tohru Matsuzaki ,  Kenji Ohmori ,  Soichiro Sato ,  Hidee Ishii ,  Haruhiko Manabe ,  Michio Ichimura ,  Fumio Suzuki

    IPC分类号： C07D41300

    CPC分类号： C07D307/79 ,  C07D307/94 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14

    摘要： An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R1 and R2 independently represent hydrogen, lower alkyl, cyano, —(CH2)n—E1—CO—G1 (wherein E1 represents a bond, O, or NH; and G1 represents hydrogen, substituted or unsubstituted lower alkyl, OR6, or NR7R8; and n represents an integer of 0 to 4), or the like; R1 and R2 are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; or R2, and R11 or R13 described below are combined to form a single bond; R3 represents hydrogen, phenyl, or halogen; R4 represents hydroxy, lower alkoxy, or the like; A represents —C(R9)(R10)— or O; B represents O, NR11, —C(R12)(R13)—, or —C(R14)(R15)— C(R16)(R17)—; D represents (i) —C(R18)(R19)—X— (wherein X represents —C(R21)(R22)—, S, or NR23), (ii) —C(R19a)═Y— [Y represents —C(R24)—Z— (wherein Z represents CONH, CONHCH2, or a bond), or N], or (iii) a bond; and R5 represents aryl, an aromatic heterocyclic group, cycloalkyl, pyridine-N-oxide, cyano, or lower alkoxycarbonyl; or pharmaceutically acceptable salts thereof.

    摘要翻译： 由下式（I）表示的含氧杂环化合物：其中R 1和R 2独立地表示氢，低级烷基，氰基， - （CH 2）nE 1 -CO-G 1（其中 E 1表示键，O或NH;且G 1表示氢，取代或未取代的低级烷基，OR 6或NR 7 R 8; n表示0〜 4）等; R 1和R 2相互结合形成饱和碳环和与其相邻的碳原子。 或R 2，以及下述R 11或R 13组合形成单键; R 3表示氢，苯基或卤素; R 4表示羟基，低级烷氧基等; A表示-C（R 9）（R 10） - 或O; B表示O，NR 11，-C（R 12）（R 13） - 或-C（R 14）（R 15）-C（R 16）（R 16） <17>） - ; D表示（i）-C（R 18）（R 19）-X-（其中X表示-C（R 21）（R 22） - ，S或NR 23） ，（ii）-C（R 19）= Y- [Y表示-C（R 24） - Z-（其中Z表示CONH，CONHCH 2或键）或N]或（iii） 一个债券 R 5表示芳基，芳香族杂环基，环烷基，吡啶-N-氧化物，氰基或低级烷氧基羰基; 或其药学上可接受的盐。

    Derivatives of benzofuran or benzodioxole
    6.
    发明授权
    Derivatives of benzofuran or benzodioxole 失效
    苯并呋喃或苯并间二氧杂环戊烯的衍生物

    公开(公告)号：US06514996B2

    公开(公告)日：2003-02-04

    申请号：US08974739

    申请日：1997-11-19

    申请人： Etsuo Ohshima ,  Takashi Kawakita ,  Koji Yanagawa ,  Kyoichiro Iida ,  Rie Koike ,  Yoshisuke Nakasato ,  Tohru Matsuzaki ,  Kenji Ohmori ,  Soichiro Sato ,  Hidee Ishii ,  Haruhiko Manabe ,  Michio Ichimura ,  Fumio Suzuki

    发明人： Etsuo Ohshima ,  Takashi Kawakita ,  Koji Yanagawa ,  Kyoichiro Iida ,  Rie Koike ,  Yoshisuke Nakasato ,  Tohru Matsuzaki ,  Kenji Ohmori ,  Soichiro Sato ,  Hidee Ishii ,  Haruhiko Manabe ,  Michio Ichimura ,  Fumio Suzuki

    IPC分类号： A61K3144

    CPC分类号： C07D307/79 ,  C07D307/94 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14

    摘要： An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R1 and R2 independently represent hydrogen, lower alkyl, cyano, —(CH2)n—E1—CO—G1 (wherein E1 represents a bond, O, or NH; and G1 represents hydrogen, substituted or unsubstituted lower alkyl, OR6, or NR7R8; and n represents an integer of 0 to 4), or the like; R1 and R2 are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; or R2, and R11 or R13 described below are combined to form a single bond; R3 represents hydrogen, phenyl, or halogen; R4 represents hydroxy, lower alkoxy, or the like; A represents —C(R9)(R10)— or O; B represents O, NR11, —C(R12)(R13)—, or —C(R14)(R15)—C(R16)(R17)—; D represents (i) —C(R18)(R19)—X— (wherein X represents —C(R21)(R22)—, S, or NR23), (ii) —C(R19a)═Y— [Y represents —C(R24)—Z— (wherein Z represents CONH, CONHCH2, or a bond), or N], or (iii) a bond; and R5 represents aryl, an aromatic heterocyclic group, cycloalkyl, pyridine-N-oxide, cyano, or lower alkoxycarbonyl; or pharmaceutically acceptable salts thereof.

    摘要翻译： 由下式（I）表示的含氧杂环化合物：其中R1和R2独立地表示氢，低级烷基，氰基， - （CH2）n-E1-CO-G1（其中E1表示键，O或NH; 并且G 1表示氢，取代或未取代的低级烷基，OR 6或NR 7 R 8; n表示0〜4的整数）等。 R 1和R 2组合​​在一起，与邻近的碳原子一起代表饱和碳环; 或R 2，R 11或R 13组合形成单键; R3表示氢，苯基或卤素; R4代表羟基，低级烷氧基等; A表示-C（R 9）（R 10） - 或O; B表示O，NR 11，-C（R 12）（R 13） - 或-C（R 14）（R 15）-C（R 16）（R 17） - ; D表示（i）-C（R 18）（R 19）-X-（其中X表示-C（R 21）（R 22） - ，S或NR 23），（ⅱ）-C（R 19a）= Y- [Y -C（R 24）-Z-（其中Z表示CONH，CONHCH 2或键）或N]或（iii）键; R5表示芳基，芳香族杂环基，环烷基，吡啶-N-氧化物，氰基或低级烷氧基羰基; 或其药学上可接受的盐。

    Imidazoquinolone derivatives
    10.
    发明授权
    Imidazoquinolone derivatives 失效
    咪唑喹啉酮衍生物

    公开(公告)号：US4994468A

    公开(公告)日：1991-02-19

    申请号：US489025

    申请日：1990-03-05

    申请人： Fumio Suzuki ,  Takeshi Kuroda ,  Yoshisuke Nakazato ,  Kenji Ohmori ,  Haruhiko Manabe

    发明人： Fumio Suzuki ,  Takeshi Kuroda ,  Yoshisuke Nakazato ,  Kenji Ohmori ,  Haruhiko Manabe

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： Novel imidazoquinolone derivative represented by the formula (I); ##STR1## wherein R.sup.1 represents hydrogen, alkyl, cycloalkyl, alkenyl aralkyl, aralkenyl or substituted or unsubstituted aryl; X represents nitrogen or ##STR2## where R.sup.2 is hydrogen, hydroxyl, alkyl, cycloalkyl, alkenyl, aralkyl, aralkenyl, substituted or unsubstituted aryl, thiol, halogen, substituted or unsubstituted aromatic heterocyclic group, or --(CH.sub.2).sub.m CO.sub.2 R.sup.6 where R.sup.6 is hydrogen or lower alkyl and m is an integer of 0 to 3; Y represents oxygen or sulfur; R.sup.3 represents alkyl, cycloalkyl, alkoxyalkly, alkenyl, aralkyl, aralkenyl, --(CH.sub.2).sub.n -- Het where Het is substituted or unsubstituted aromatic heterocyclic group and n is an integer of 1 to 3 or --(CH.sub.2).sub.n CO.sub.2 R.sup.6a where n has the same meaning as defined above and R.sup.6a has the same meaning as defined as to R.sup.6 ; each of R.sup.4 and R.sup.5 independently represents hydrogen, lower alkyl, trifluoromethyl, cycloalkyl, halogen, hydroxyl, lower alkoxyl, lower alkylthio, nitro, amino, lower alkylamino, lower alkanoylamino, aroylamino, lower alkanoyl or aroyl; and a pharmaceutically acceptable salt thereof. The Compound (I) and a pharmaceutically acceptable salt thereof show bronchodilatory and antiallergic activities, and are useful for treating respiratory disorders such as bronchial asthma.