公开(公告)号：US10774299B2

公开(公告)日：2020-09-15

申请号：US15345590

申请日：2016-11-08

Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

Inventor： Parrish M. Galliher ,  Thomas Erdenberger ,  Colin R. Tuohey ,  Joseph D. Crowell ,  Richard L. Damren

IPC: C12M1/00 ,  C12M3/00 ,  C12M1/02 ,  B01F15/00 ,  F28D7/02 ,  F28F3/12 ,  F28F13/06 ,  F28D1/06 ,  F28D1/02 ,  B01J19/00 ,  B01J19/18 ,  B01J19/24 ,  B65D30/08 ,  F16L11/04 ,  F28D1/047 ,  F28F9/013 ,  F28D21/00 ,  F28F13/00 ,  F28F9/22

Abstract: Disclosed is a jacketed, tiered baffle, bioreactor tank comprising an outer cylindrical-shaped jacket and a cylindrical tank having an inner tank surface defining a chamber configured for supporting a flexible bag disposed within the chamber, and an outer tank surface having tiered baffles configured for routing a heat exchange fluid around the entirety of the outer tank surface, the cylindrical tank disposed axially within the outer cylindrical-shaped jacket. The outer cylindrical-shaped jacket is sealed to the cylindrical tank in a manner sufficient to prevent or minimize loss of the heat exchange fluid.

公开(公告)号：US10442674B2

公开(公告)日：2019-10-15

申请号：US15223270

申请日：2016-07-29

Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

Inventor： Colin R. Tuohey ,  Thomas Erdenberger ,  Richard L. Damren ,  Kenneth Clapp ,  Parrish M. Galliher ,  Jonathan Kenney

IPC: B67D7/02 ,  C12M1/00 ,  F16K31/44 ,  F16K1/04 ,  F16K1/20 ,  F16K1/24 ,  F16K7/10 ,  B67D7/36 ,  B67D7/84 ,  F16K31/126 ,  F16K31/22 ,  F16K31/50 ,  B01F13/08 ,  B01F15/00

Abstract: Disclosed herein are embodiments of a valve assembly for preventing dead leg spaces in a container or tubing, the embodiments including a three-way valve system for controlling back-pressure in a fluid generating device, such as a single-use high pressure bioreactor. Also disclosed is a pressurized reactor system for bioprocessing, comprising a single-use container including a flexible wall or a semi-rigid wall.

公开(公告)号：US20140260712A1

公开(公告)日：2014-09-18

申请号：US14353344

申请日：2012-10-28

Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

Inventor： Richard L. Damren ,  Colin R. Tuohey ,  Thomas Erdenberger ,  Michael Fisher ,  Jonathan A. Kenney ,  Parrish M. Galliher ,  Joseph D. Crowell

IPC: G01D11/24

CPC classification number: G01D11/24 ,  A61M39/18

Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid vessel or tubing having a distal aseptic connector for coupling to the vessel or tubing, the probe sheath comprising at least a portion that is rigid, the probe sheath extending longitudinally from the aseptic connector and having at least one inner longitudinal lumen configured to receive an elongate sensor or probe body and to permit longitudinal movement of the sensor/probe body within the probe sheath lumen, and an actuator for deploying a probe within the vessel or tubing by advancing the probe body through the aseptic connector to a position where the probe can measure at least one parameter within the vessel or tubing is disclosed herein.

Abstract translation: 探针组件，用于将探针插入到具有远端无菌连接器的柔性或半刚性容器或管道中，所述远端无菌连接器用于联接到容器或管道，所述探针护套包括至少一部分刚性部分，探针护套从无菌 连接器，并且具有至少一个内部纵向内腔，其构造成接收细长的传感器或探针主体并且允许传感器/探针主体在探针鞘腔内的纵向移动;以及致动器，用于通过推进 探针本体通过无菌连接器到达探针可以测量容器或管道内的至少一个参数的位置。

公开(公告)号：US10767154B2

公开(公告)日：2020-09-08

申请号：US15098800

申请日：2016-04-14

Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

Inventor： Richard L. Damren ,  Thomas Erdenberger ,  Colin R. Tuohey ,  Joseph D. Crowell ,  Parrish M. Galliher ,  Kenneth P Clapp ,  Peter A. Mitchell

IPC: F28F13/06 ,  F28F3/12 ,  F28D1/02 ,  B01J19/18 ,  B01J19/00 ,  F28D1/06 ,  C12M1/02 ,  C12M1/00 ,  B01F15/00 ,  F28D7/02 ,  B01F13/08 ,  B01F15/06 ,  F28F13/00 ,  F28D21/00

Abstract: A heat exchange module for use in a chemical, pharmaceutical or biological reactor system includes a generally hollow body having an interior space for receiving a replaceable or single use reactant container, and at least one thermally conductive surface adapted to contact the replaceable reactant container to facilitate heat transfer, a fluid circulation path formed within the body between an outer wall of the body and an inner wall of the body through which a heat exchange fluid can be circulated, and at least one baffle protruding from the inner wall of the body into the interior space.

公开(公告)号：US09475686B2

公开(公告)日：2016-10-25

申请号：US14383328

申请日：2013-03-07

Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

Inventor： Colin R. Tuohey ,  Thomas Erdenberger ,  Richard L. Damren ,  Kenneth Clapp ,  Parrish M. Galliher ,  Jonathan Kenney

IPC: B67D7/02 ,  C12M1/00 ,  F16K31/44 ,  F16K1/04 ,  F16K1/20 ,  F16K1/24 ,  F16K7/10 ,  B67D7/36 ,  B67D7/84 ,  F16K31/126 ,  F16K31/22 ,  F16K31/50 ,  B01F13/08 ,  B01F15/00

CPC classification number: B67D7/0294 ,  B01F13/08 ,  B01F15/0085 ,  B67D7/36 ,  B67D7/84 ,  C12M23/14 ,  C12M23/26 ,  C12M23/28 ,  C12M29/14 ,  F16K1/04 ,  F16K1/20 ,  F16K1/24 ,  F16K7/10 ,  F16K31/126 ,  F16K31/22 ,  F16K31/44 ,  F16K31/508

Abstract: Disclosed herein are embodiments of a valve assembly for preventing dead leg spaces in a container or tubing, the embodiments including a three-way valve system for controlling back-pressure in a fluid generating device, such as a single-use high pressure bioreactor. Also disclosed is a pressurized reactor system for bioprocessing, comprising a single-use container including a flexible wall or a semi-rigid wall.

Abstract translation: 这里公开了用于防止容器或管道中的死腿空间的阀组件的实施例，该实施例包括用于控制诸如一次性高压生物反应器的流体产生装置中的背压的三通阀系统。 还公开了一种用于生物处理的加压反应器系统，其包括包含柔性壁或半刚性壁的一次性容器。

公开(公告)号：US09340763B2

公开(公告)日：2016-05-17

申请号：US13691998

申请日：2012-12-03

Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

Inventor： Richard L. Damren ,  Thomas Erdenberger ,  Colin R. Tuohey ,  Joseph D. Crowell ,  Parrish M. Galliher ,  Kenneth P. Clapp ,  Peter A. Mitchell

IPC: B01J8/00 ,  C12M1/00 ,  C12M1/02 ,  B01F15/00 ,  B01J19/00 ,  B01J19/18 ,  F28F3/12 ,  F28F13/06 ,  F28D1/06 ,  F28D1/02 ,  B01J19/24 ,  B65D30/08 ,  F16L11/04 ,  F28D1/047 ,  F28F9/013 ,  F28D7/02 ,  F28D21/00 ,  F28F13/00

CPC classification number: C12M41/24 ,  B01F15/0085 ,  B01J19/006 ,  B01J19/18 ,  B01J19/24 ,  B01J2219/0002 ,  B01J2219/00081 ,  B01J2219/00085 ,  B01J2219/0009 ,  B01J2219/00094 ,  B01J2219/00765 ,  B01J2219/00768 ,  B01J2219/24 ,  B65D31/02 ,  C12M23/14 ,  C12M23/26 ,  C12M23/28 ,  C12M27/20 ,  C12M41/18 ,  F16L11/04 ,  F28D1/0213 ,  F28D1/047 ,  F28D1/06 ,  F28D7/024 ,  F28D7/026 ,  F28D2021/0022 ,  F28D2021/0077 ,  F28D2021/0078 ,  F28F3/12 ,  F28F9/0131 ,  F28F13/06 ,  F28F2009/228 ,  F28F2013/006 ,  F28F2255/02

Abstract: A heat exchange module for use in a chemical, pharmaceutical or biological reactor system can include a body configured to be disposed in the reactor system having an inner replaceable reactant container is disclosed. The body can further include at least one thermally conductive surface adapted to contact the inner replaceable reactant container to facilitate heat transfer. Furthermore, the heat exchange module can include a heat exchanger disposed within the module body and can include a fluid circulation path through which a heat exchange fluid can be circulated.

Abstract translation: 用于化学，药物或生物反应器系统的热交换模块可以包括被配置为设置在具有内部可更换反应物容器的反应器系统中的主体。 主体还可包括适于接触内部可更换反应物容器以促进热传递的至少一个导热表面。 此外，热交换模块可以包括设置在模块体内的热交换器，并且可以包括可以循环热交换流体的流体循环路径。

公开(公告)号：US09534196B2

公开(公告)日：2017-01-03

申请号：US14367318

申请日：2013-01-14

Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

Inventor： Parrish M. Galliher ,  Thomas Erdenberger ,  Colin R. Tuohey ,  Joseph D. Crowell ,  Richard L. Damren

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/02 ,  B01F15/00 ,  B01J19/00 ,  B01J19/18 ,  F28F3/12 ,  F28F13/06 ,  F28D1/06 ,  F28D1/02 ,  B01J19/24 ,  B65D30/08 ,  F16L11/04 ,  F28D1/047 ,  F28F9/013 ,  F28D7/02 ,  F28D21/00 ,  F28F13/00

CPC classification number: C12M41/24 ,  B01F15/0085 ,  B01J19/006 ,  B01J19/18 ,  B01J19/24 ,  B01J2219/0002 ,  B01J2219/00081 ,  B01J2219/00085 ,  B01J2219/0009 ,  B01J2219/00094 ,  B01J2219/00765 ,  B01J2219/00768 ,  B01J2219/24 ,  B65D31/02 ,  C12M23/14 ,  C12M23/26 ,  C12M23/28 ,  C12M27/20 ,  C12M41/18 ,  F16L11/04 ,  F28D1/0213 ,  F28D1/047 ,  F28D1/06 ,  F28D7/024 ,  F28D7/026 ,  F28D2021/0022 ,  F28D2021/0077 ,  F28D2021/0078 ,  F28F3/12 ,  F28F9/0131 ,  F28F13/06 ,  F28F2009/228 ,  F28F2013/006 ,  F28F2255/02

Abstract: Disclosed is a heat exchange module for use in a chemical, pharmaceutical or biological reactor system, the module configured to be disposed in the reactor system having a flexible single use container, and including at least one thermally conductive surface adapted to contact the flexible single use container to facilitate heat transfer, and a fluid circulation path through which a heat exchange fluid can be circulated.

Abstract translation: 公开了一种用于化学，药物或生物反应器系统的热交换模块，所述模块被配置为设置在具有柔性单用途容器的反应器系统中，并且包括适于接触柔性单次使用的至少一个导热表面 容器以便于传热，以及流体循环路径，热交换流体可通过该流体循环路径循环。

公开(公告)号：US20150053307A1

公开(公告)日：2015-02-26

申请号：US14383328

申请日：2013-03-07

Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

Inventor： Colin R. Tuohey ,  Thomas Erdenberger ,  Richard L. Damren ,  Kenneth Clapp ,  Parrish M. Galliher ,  Jonathan Kenney

IPC: B67D7/02 ,  B67D7/84 ,  B67D7/36

CPC classification number: B67D7/0294 ,  B01F13/08 ,  B01F15/0085 ,  B67D7/36 ,  B67D7/84 ,  C12M23/14 ,  C12M23/26 ,  C12M23/28 ,  C12M29/14 ,  F16K1/04 ,  F16K1/20 ,  F16K1/24 ,  F16K7/10 ,  F16K31/126 ,  F16K31/22 ,  F16K31/44 ,  F16K31/508

Abstract: Disclosed herein are embodiments of a valve assembly for preventing dead leg spaces in a container or tubing, the embodiments including a three-way valve system for controlling back-pressure in a fluid generating device, such as a single-use high pressure bioreactor. Also disclosed is a pressurized reactor system for bioprocessing, comprising a single-use container including a flexible wall or a semi-rigid wall.

Abstract translation: 这里公开了用于防止容器或管道中的死腿空间的阀组件的实施例，该实施例包括用于控制诸如一次性高压生物反应器的流体产生装置中的背压的三通阀系统。 还公开了一种用于生物处理的加压反应器系统，其包括包含柔性壁或半刚性壁的一次性容器。

公开(公告)号：US09891080B2

公开(公告)日：2018-02-13

申请号：US14353344

申请日：2012-10-28

Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

Inventor： Richard L. Damren ,  Colin R. Tuohey ,  Thomas Erdenberger ,  Michael Fisher ,  Jonathan A. Kenney ,  Parrish M. Galliher ,  Joseph D. Crowell

IPC: G01D11/24 ,  A61M39/18

CPC classification number: G01D11/24 ,  A61M39/18

Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid vessel or tubing having a distal aseptic connector for coupling to the vessel or tubing, the probe sheath comprising at least a portion that is rigid, the probe sheath extending longitudinally from the aseptic connector and having at least one inner longitudinal lumen configured to receive an elongate sensor or probe body and to permit longitudinal movement of the sensor/probe body within the probe sheath lumen, and an actuator for deploying a probe within the vessel or tubing by advancing the probe body through the aseptic connector to a position where the probe can measure at least one parameter within the vessel or tubing is disclosed herein.