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    CONTINUOUS PERFUSION BIOREACTOR SYSTEM
    1.
    发明申请
    CONTINUOUS PERFUSION BIOREACTOR SYSTEM 审中-公开

    公开(公告)号：US20150368602A1

    公开(公告)日：2015-12-24

    申请号：US14743960

    申请日：2015-06-18

    Applicant: GE Healthcare Bio-Sciences Corp.

    Inventor： Parrish M. Galliher ,  Geoffrey L. Hodge ,  Michael Fisher ,  Patrick Guertin ,  Dan Mardirosian

    IPC: C12M1/00 ,  B01D29/13 ,  C12M3/00

    CPC classification number: C12M29/10 ,  B01D29/13 ,  C12M23/14 ,  C12M23/26 ,  C12M23/48 ,  C12M27/02 ,  C12M27/20 ,  C12M29/00 ,  C12M29/18 ,  C12M47/10

    Abstract: Systems and methods for containing and manipulating liquids, including vessels and unit operations or components of cell culture, cell containment, bioreactor, and/or pharmaceutical manufacturing systems, are provided. In certain embodiments, such vessels and unit operations are directed to continuous perfusion reactor or bioreactor systems and may include one or more disposable components. For instance, in one aspect, a system includes an apparatus in the form of a bioreactor for harvesting cells which produce one or more products. The apparatus may include a disposable, collapsible bag adapted for containing a liquid, the collapsible bag in fluid communication with a liquid-solids (e.g., cell) separation device. For example, an outlet of the collapsible bag may be connected to an inlet of the separation device, and an outlet of the separation device may be connected to an inlet of the collapsible bag for recycle. Accordingly, after separating the cells from the liquid in the separation device, the cells can be flowed back into the collapsible bag where they can be re-harvested. Meanwhile, product contained in the liquid can be collected in a separate container. The efficiency of product formation in such a system may be enhanced by using mixing systems described herein.

    Single use controlled environment module
    2.
    发明授权
    Single use controlled environment module 有权

    公开(公告)号：US10190087B2

    公开(公告)日：2019-01-29

    申请号：US13623584

    申请日：2012-09-20

    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

    Inventor： Parrish M. Galliher ,  Michael Fisher ,  Geoffrey L. Hodge

    IPC: C12M1/12 ,  B01L1/02

    Abstract: Disclosed herein is a single use, controlled environment manufacturing module in the form of a sterile sealed bag formed of a substantially flexible material, such that the bag can be inflated and deflated for transport and/or disposal. The flexible bag has one or more access ports and connectors to accommodate a variety of biochemical or pharmaceutical manufacturing processes to be carried out within the flexible bag. The interiors of one or more disclosed modules can be connected, forming a module train.

    PROBE ASSEMBLY
    4.
    发明申请
    PROBE ASSEMBLY 有权
    探测组件

    公开(公告)号：US20140260712A1

    公开(公告)日：2014-09-18

    申请号：US14353344

    申请日：2012-10-28

    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

    Inventor： Richard L. Damren ,  Colin R. Tuohey ,  Thomas Erdenberger ,  Michael Fisher ,  Jonathan A. Kenney ,  Parrish M. Galliher ,  Joseph D. Crowell

    IPC: G01D11/24

    CPC classification number: G01D11/24 ,  A61M39/18

    Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid vessel or tubing having a distal aseptic connector for coupling to the vessel or tubing, the probe sheath comprising at least a portion that is rigid, the probe sheath extending longitudinally from the aseptic connector and having at least one inner longitudinal lumen configured to receive an elongate sensor or probe body and to permit longitudinal movement of the sensor/probe body within the probe sheath lumen, and an actuator for deploying a probe within the vessel or tubing by advancing the probe body through the aseptic connector to a position where the probe can measure at least one parameter within the vessel or tubing is disclosed herein.

    Abstract translation: 探针组件，用于将探针插入到具有远端无菌连接器的柔性或半刚性容器或管道中，所述远端无菌连接器用于联接到容器或管道，所述探针护套包括至少一部分刚性部分，探针护套从无菌 连接器，并且具有至少一个内部纵向内腔，其构造成接收细长的传感器或探针主体并且允许传感器/探针主体在探针鞘腔内的纵向移动;以及致动器，用于通过推进 探针本体通过无菌连接器到达探针可以测量容器或管道内的至少一个参数的位置。

    Probe assembly
    6.
    发明授权
    Probe assembly 有权

    公开(公告)号：US09891080B2

    公开(公告)日：2018-02-13

    申请号：US14353344

    申请日：2012-10-28

    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

    Inventor： Richard L. Damren ,  Colin R. Tuohey ,  Thomas Erdenberger ,  Michael Fisher ,  Jonathan A. Kenney ,  Parrish M. Galliher ,  Joseph D. Crowell

    IPC: G01D11/24 ,  A61M39/18

    CPC classification number: G01D11/24 ,  A61M39/18

    Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid vessel or tubing having a distal aseptic connector for coupling to the vessel or tubing, the probe sheath comprising at least a portion that is rigid, the probe sheath extending longitudinally from the aseptic connector and having at least one inner longitudinal lumen configured to receive an elongate sensor or probe body and to permit longitudinal movement of the sensor/probe body within the probe sheath lumen, and an actuator for deploying a probe within the vessel or tubing by advancing the probe body through the aseptic connector to a position where the probe can measure at least one parameter within the vessel or tubing is disclosed herein.

    DISPOSABLE BIOREACTOR CONDENSER BAG AND FILTER HEATER
    8.
    发明申请
    DISPOSABLE BIOREACTOR CONDENSER BAG AND FILTER HEATER 审中-公开
    可处理的生物反应器冷凝器袋和过滤器加热器

    公开(公告)号：US20160376539A1

    公开(公告)日：2016-12-29

    申请号：US15259338

    申请日：2016-09-08

    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.

    Inventor： Richard Damren ,  Colin Touhey ,  Thomas Erdenberger ,  Michael Fisher ,  Geoffrey Hodge ,  Patrick Guertin ,  Parrish Galliher

    IPC: C12M1/00 ,  B01D46/42 ,  B01D53/26 ,  C12M1/34 ,  B01D5/00

    CPC classification number: C12M29/26 ,  B01D5/0042 ,  B01D5/0093 ,  B01D46/4263 ,  B01D53/265 ,  C12M23/28 ,  C12M29/04 ,  C12M41/12

    Abstract: Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioreactor, the system comprising: a condenser container capable of holding a fluid, the condenser container comprising: an outer wall surface and an inner wall surface, the inner wall surface defining an interior chamber for holding the fluid; and a first fitment attached to the outer wall surface of the condenser container, the first fitment forming a first port configured to allow the moist gas stream to flow through the first port and into the interior chamber; a second fitment attached to the outer wall surface of the condenser container, the second fitment forming a second port configured to allow a dried gas to flow from the interior chamber and out of the second port; and a cooling device in contact with at least one portion of the outer wall surface of the condenser container and arranged to cool the at least one portion of the outer wall surface of the condenser container, thereby to condense moisture in the moist gas stream and forming a dry gas stream for entering or leaving the bioreactor.

    Abstract translation: 本文公开了一种用于冷凝进入生物反应器或离开生物反应器的湿气流中的水分的系统和方法，所述系统包括：能够保持流体的冷凝器容器，所述冷凝器容器包括：外壁表面和内壁表面 所述内壁表面限定用于保持流体的内部腔室; 以及附接到所述冷凝器容器的外壁表面的第一配件，所述第一配件形成第一端口，所述第一端口被配置为允许所述湿气流流过所述第一端口并进入所述内部室; 附接到冷凝器容器的外壁表面的第二配件，所述第二配件形成第二端口，所述第二端口被配置为允许干燥的气体从所述内部室流出并且从所述第二端口流出; 以及与所述冷凝器容器的所述外壁表面的至少一部分接触并且布置成冷却所述冷凝器容器的所述外壁表面的所述至少一部分的冷却装置，从而冷凝所述湿气流中的水分并形成 用于进入或离开生物反应器的干燥气流。

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