公开(公告)号：US09266948B2

公开(公告)日：2016-02-23

申请号：US14290349

申请日：2014-05-29

Applicant: Genentech, Inc.

Inventor： Xiumin Wu ,  Van Wu ,  Lanlan Yu ,  Napoleone Ferrara ,  Wei-Ghing Liang ,  Yu-Ju G. Meng ,  Janet Tien

IPC: C07H21/04 ,  C07K16/22 ,  C07K16/24 ,  A61K39/00

CPC classification number: C07K16/22 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/24 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention concerns antibodies to Bv8 and the uses of same.

Abstract translation: 本发明涉及Bv8的抗体及其用途。

公开(公告)号：US10662254B2

公开(公告)日：2020-05-26

申请号：US15967154

申请日：2018-04-30

Applicant: GENENTECH, INC.

Inventor： Yu-Ju G. Meng ,  Hok Seon Kim ,  Ingrid Kim ,  Christoph Spiess

IPC: C07K16/42

Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab′)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.

公开(公告)号：US20200308304A1

公开(公告)日：2020-10-01

申请号：US16852136

申请日：2020-04-17

Applicant: GENENTECH, INC.

Inventor： Yu-Ju G. Meng ,  Hok Seon Kim ,  Ingrid Kim ,  Christoph Spiess

IPC: C07K16/42

Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab′)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.

公开(公告)号：US20180305462A1

公开(公告)日：2018-10-25

申请号：US15967154

申请日：2018-04-30

Applicant: GENENTECH, INC.

Inventor： Yu-Ju G. Meng ,  Hok Seon Kim ,  Ingrid Kim ,  Christoph Spiess

IPC: C07K16/42

CPC classification number: C07K16/4283 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/94

Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab′)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.

公开(公告)号：US09625462B2

公开(公告)日：2017-04-18

申请号：US14814139

申请日：2015-07-30

Applicant: Genentech, Inc.

Inventor： Yu-Ju G. Meng ,  Kyu H. Hong ,  Johnny Gutierrez

IPC: A61K39/00 ,  C07K16/00 ,  G01N33/574 ,  C07K16/22 ,  G01N33/74

CPC classification number: G01N33/57496 ,  C07K16/22 ,  G01N33/74 ,  G01N2333/475

Abstract: The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA methods and kits for VEGF as an antigen are provided to detect types of VEGF levels in biological samples from animal models and human patients and can be used as a diagnostic/prognostic index.