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1.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer 有权核苷酸和氨基酸序列，以及其用于诊断卵巢癌的测定和方法公开(公告)号：US07553948B2
公开(公告)日：2009-06-30
申请号：US11714282
申请日：2007-03-06
申请人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
摘要翻译： 卵巢癌的新型标志物既敏感又准确。 与卵巢正常组织相反，这些标志物特异性地在卵巢癌中过表达和/或差异表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与卵巢癌中可能诊断相关的信息。 本发明的标记物单独或组合显示卵巢癌与非癌状态之间的高度差异检测。
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2.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer 有权新型核苷酸和氨基酸序列，以及其用于诊断卵巢癌的测定和方法公开(公告)号：US20090004648A1
公开(公告)日：2009-01-01
申请号：US11714282
申请日：2007-03-06
申请人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
摘要翻译： 卵巢癌的新型标志物既敏感又准确。 与卵巢正常组织相反，这些标志物特异性地在卵巢癌中过表达和/或差异表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与卵巢癌中可能诊断相关的信息。 本发明的标记物单独或组合显示卵巢癌与非癌状态之间的高度差异检测。
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3.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer 有权核苷酸和氨基酸序列，以及其用于诊断卵巢癌的测定和方法公开(公告)号：US07906635B2
公开(公告)日：2011-03-15
申请号：US12354641
申请日：2009-01-15
申请人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/156 , Y10T436/143333
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
摘要翻译： 卵巢癌的新型标志物既敏感又准确。 与卵巢正常组织相反，这些标志物特异性地在卵巢癌中过表达和/或差异表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与卵巢癌中可能诊断相关的信息。 本发明的标记物单独或组合显示卵巢癌与非癌状态之间的高度差异检测。
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4.发明申请Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of use Thereof for Diagnosis of Ovarian Cancer 有权新型核苷酸和氨基酸序列，以及用于诊断卵巢癌的检测方法公开(公告)号：US20100124786A1
公开(公告)日：2010-05-20
申请号：US12354641
申请日：2009-01-15
申请人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/156 , Y10T436/143333
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
摘要翻译： 卵巢癌的新型标志物既敏感又准确。 与卵巢正常组织相反，这些标志物特异性地在卵巢癌中过表达和/或差异表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与卵巢癌中可能诊断相关的信息。 本发明的标记物单独或组合显示卵巢癌与非癌状态之间的高度差异检测。
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5.发明申请公开(公告)号：US20060040278A1
公开(公告)日：2006-02-23
申请号：US11050857
申请日：2005-01-27
申请人： Gad Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
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6.发明申请Novel nucleotide and amino acid sequences, and assays methods of use thereof for diagnosis of colon cancer 审中-公开新型核苷酸和氨基酸序列及其用于诊断结肠癌的测定方法公开(公告)号：US20090215046A1
公开(公告)日：2009-08-27
申请号：US11976324
申请日：2007-10-23
申请人： Rotem Sorek , Michal Ayalon-Soffer , Dvir Dahary , Amit Novik , Amir Toporik , Alexander Diber , Guy Kol , Sarah Pollock , Zurit Levine , Gad S. Cojocaru , Ronen Shemesh , Yossi Cohen , Osnat Sella-Tavor , Shirley Sameah-Greenwald , Shira Walach
发明人： Rotem Sorek , Michal Ayalon-Soffer , Dvir Dahary , Amit Novik , Amir Toporik , Alexander Diber , Guy Kol , Sarah Pollock , Zurit Levine , Gad S. Cojocaru , Ronen Shemesh , Yossi Cohen , Osnat Sella-Tavor , Shirley Sameah-Greenwald , Shira Walach
IPC分类号： C12Q1/68 , C07H21/02 , C07K14/47 , C12N15/63 , C12Q1/02 , C07K17/00 , G01N33/574 , C12N5/06 , C12P21/00
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/57419
摘要： Novel markers for colon cancer that are both sensitive and accurate. These markers are overexpressed in colon cancer specifically, as opposed to normal colon tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of colon cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between colon cancer and non-cancerous states.
摘要翻译： 结肠癌的新型标志物既敏感又准确。 与正常结肠组织相反，这些标志物特异性地在结肠癌中过度表达。 这些标记物单独或组合在患者样本中的测量提供了诊断者可以与结肠癌可能诊断相关的信息。 本发明的标记物单独或组合显示结肠癌与非癌状态之间的高度差异检测。
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7.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis 有权核苷酸和氨基酸序列，以及用于诊断的测定及其使用方法公开(公告)号：US07842459B2
公开(公告)日：2010-11-30
申请号：US11051646
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
发明人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
摘要翻译： 新型剪接变体核酸序列。 根据本发明的新型剪接变体及其核酸序列可任选地用于诊断如本文所述的变体可检测的疾病。
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8.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis 有权新型核苷酸和氨基酸序列，以及用于诊断的测定和方法公开(公告)号：US20100120022A1
公开(公告)日：2010-05-13
申请号：US11051646
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
发明人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
摘要翻译： 新型剪接变体核酸序列。 根据本发明的新型剪接变体及其核酸序列可任选地用于诊断如本文所述的变体可检测的疾病。
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9.发明申请NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS OF BREAST CANCER 审中-公开新型核酸和氨基酸序列及其用于诊断乳腺癌的测定及其使用方法公开(公告)号：US20090286957A1
公开(公告)日：2009-11-19
申请号：US12350814
申请日：2009-01-08
申请人： Amir Toporik , Dvir Dahary , Rotem Sorek , Sarah Pollock , Zurit Levine , Pinchas Akiva , Alexander Diber , Amit Novik , Osnat Sella-Tavor , Michal Ayalon-Soffer , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Naomi Keren , Maxim Shklar
发明人： Amir Toporik , Dvir Dahary , Rotem Sorek , Sarah Pollock , Zurit Levine , Pinchas Akiva , Alexander Diber , Amit Novik , Osnat Sella-Tavor , Michal Ayalon-Soffer , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Naomi Keren , Maxim Shklar
IPC分类号： C07K14/435
CPC分类号： G01N33/57415 , C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between breast cancer and non-cancerous states.
摘要翻译： 乳腺癌的新型标记物既敏感又准确。 这些标志物在乳腺癌中特异性地过表达，与正常的乳腺组织相反。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与乳腺癌的可能诊断相关的信息。 本发明的标记物单独或组合显示乳腺癌与非癌状态之间的高度差异检测。
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10.发明申请Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Lung Cancer 审中-公开新型核苷酸和氨基酸序列及其用于肺癌诊断的方法及方法公开(公告)号：US20100068736A1
公开(公告)日：2010-03-18
申请号：US12557253
申请日：2009-09-10
申请人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad S. Cojocaru , Michal Ayalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
发明人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad S. Cojocaru , Michal Ayalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
IPC分类号： G01N33/53 , C07K2/00 , C07K16/00 , G01N33/574
CPC分类号： G01N33/57423 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
摘要翻译： 肺癌的新型标志物既敏感又准确。 与正常肺组织相反，这些标志物特异性地在肺癌中过度表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与肺癌可能诊断相关的信息。 本发明的标记物单独或组合显示出肺癌和非癌状态之间的高度差异检测。
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