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    Methods for identifying small molecules that bind specific RNA structural motifs
    6.
    发明申请
    Methods for identifying small molecules that bind specific RNA structural motifs 审中-公开
    鉴定结合特异性RNA结构基序的小分子的方法

    公开(公告)号：US20060194234A1

    公开(公告)日：2006-08-31

    申请号：US11359721

    申请日：2006-02-21

    申请人： Michael Conn ,  Mathew Pelligrini ,  Seongwoo Hwang ,  Young-Choon Moon ,  Neil Almstead

    发明人： Michael Conn ,  Mathew Pelligrini ,  Seongwoo Hwang ,  Young-Choon Moon ,  Neil Almstead

    IPC分类号： C40B40/08

    CPC分类号： C12N15/115 ,  C12N15/1048

    摘要： The present invention relates to a method for screening and identifying test compounds that bind to a preselected target ribonucleic acid (“RNA”). Direct, non-competitive binding assays are advantageously used to screen bead-based libraries of compounds for those that selectively bind to a preselected target RNA. Binding of target RNA molecules to a particular test compound is detected using any physical method that measures the altered physical property of the target RNA bound to a test compound. The structure of the test compound attached to the labeled RNA is also determined. The methods used will depend, in part, on the nature of the library screened. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.

    摘要翻译： 本发明涉及筛选和鉴定结合预选靶核糖核酸（“RNA”）的测试化合物的方法。 直接的非竞争性结合测定法有利地用于筛选选择性结合预选靶RNA的化合物的基于珠的文库。 使用测量与测试化合物结合的靶RNA的改变的物理性质的任何物理方法检测靶RNA分子与特定测试化合物的结合。 还测定了附着于标记的RNA的测试化合物的结构。 所使用的方法部分取决于所筛选图书馆的性质。 本发明的方法提供了用于识别药物引线的化合物文库的高通量筛选的简单，灵敏的测定。

    Methods for identifying small molecules that bind specific rna structural motifs
    7.
    发明申请
    Methods for identifying small molecules that bind specific rna structural motifs 审中-公开
    用于鉴定结合特异性rna结构基序的小分子的方法

    公开(公告)号：US20050142545A1

    公开(公告)日：2005-06-30

    申请号：US10475026

    申请日：2002-04-11

    申请人： Michael Conn ,  Matthew Pelligrini ,  Seongwoo Hwang ,  Young-Choon Moon ,  Neil Almstead

    发明人： Michael Conn ,  Matthew Pelligrini ,  Seongwoo Hwang ,  Young-Choon Moon ,  Neil Almstead

    IPC分类号： C12N15/10 ,  C12Q1/68

    CPC分类号： C12N15/115 ,  C12N15/1048

    摘要： The present invention relates to a method for screening and identifying test compounds that bind to a preselected target ribonucleic acid (“RNA”). Direct, non-competitive binding assays are advantageously used to screen bead-based libraries of compounds for those that selectively bind to a preselected target RNA. Binding of target RNA molecules to a particular test compound is detected using any physical method that measures the altered physical property of the target RNA bound to a test compound. The structure of the test compound attached to the labeled RNA is also determined. The methods used will depend, in part, on the nature of the library screened. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.

    摘要翻译： 本发明涉及筛选和鉴定结合预选靶核糖核酸（“RNA”）的测试化合物的方法。 直接的非竞争性结合测定法有利地用于筛选选择性结合预选靶RNA的化合物的基于珠的文库。 使用测量与测试化合物结合的靶RNA的改变的物理性质的任何物理方法检测靶RNA分子与特定测试化合物的结合。 还测定了附着于标记的RNA的测试化合物的结构。 所使用的方法部分取决于所筛选图书馆的性质。 本发明的方法提供了用于识别药物引线的化合物文库的高通量筛选的简单，灵敏的测定。