公开(公告)号：US09994646B2

公开(公告)日：2018-06-12

申请号：US14735024

申请日：2015-06-09

Applicant: Genentech, Inc.

Inventor： Erin H. Christensen ,  Dan L. Eaton ,  Andrew C. Vendel ,  Bernd Wranik

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/32

CPC classification number: C07K16/468 ,  C07K16/283 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/53 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/73

Abstract: The invention provides engineered protein complexes constructed using a coiled coil and/or a tether and methods for making, using, and purifying such complexes, such as multispecific antibodies or other multispecific Fc containing complexes.

公开(公告)号：US11046776B2

公开(公告)日：2021-06-29

申请号：US15669861

申请日：2017-08-04

Applicant: Genentech, Inc.

Inventor： Greg Lazar ,  Yanli Yang ,  Erin H. Christensen ,  Julie Hang ,  Jeong Kim ,  Seth Harris

IPC: A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  A61K39/00

Abstract: Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.

公开(公告)号：US09688758B2

公开(公告)日：2017-06-27

申请号：US14455189

申请日：2014-08-08

Applicant: Genentech, Inc.

Inventor： Bernd Wranik ,  Dan L. Eaton ,  Erin H. Christensen ,  Jiansheng Wu

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C07K16/18 ,  C07K16/22 ,  C07K16/24 ,  C07K16/26

CPC classification number: C07K16/28 ,  C07K16/00 ,  C07K16/18 ,  C07K16/22 ,  C07K16/24 ,  C07K16/26 ,  C07K2317/31 ,  C07K2317/515 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/64

Abstract: The invention provides engineered heteromultimeric protein complexes constructed using one, two, or three tethers and methods for making, using, and purifying such complexes, such as antibodies with different binding properties.