公开(公告)号：US20160230226A1

公开(公告)日：2016-08-11

申请号：US14493649

申请日：2014-09-23

Applicant: GENENTECH, INC.

Inventor： Alexander R. Abbas ,  Joseph R. Arron ,  Sanjay Chandriani ,  Guiquan Jia ,  Nicholas J.I. Lewin-Koh ,  Daryle DePianto

IPC: C12Q1/68 ,  G01N33/68 ,  C07K16/24

CPC classification number: C12Q1/6883 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/244 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2333/521 ,  G01N2333/775 ,  G01N2333/96494 ,  G01N2800/12 ,  G01N2800/52

Abstract: Compositions, kits and methods for assessing the prognosis of idiopathic pulmonary fibrosis in patients are provided. In addition, compositions, kits and methods for diagnosing subtypes of idiopathic pulmonary fibrosis are provided. Also provided are methods for treating idiopathic pulmonary fibrosis.

Abstract translation: 提供了用于评估患者特发性肺纤维化预后的组合物，试剂盒和方法。 此外，提供了用于诊断特发性肺纤维化亚型的组合物，试剂盒和方法。 还提供了治疗特发性肺纤维化的方法。

公开(公告)号：US09995755B2

公开(公告)日：2018-06-12

申请号：US14021947

申请日：2013-09-09

Applicant: Genentech, Inc.

Inventor： Joseph R. Arron ,  Richard W. Erickson ,  Michelle Freemer ,  Meredith Hazen ,  Guiquan Jia ,  John G. Matthews ,  Wendy Putnam ,  Heleen Scheerens ,  Yanan Zheng

IPC: A61K39/00 ,  A61K45/00 ,  G01N33/68 ,  C07K16/28 ,  A61K39/395 ,  C07K16/18 ,  A61K31/522 ,  A61K31/573 ,  A61K45/06

CPC classification number: G01N33/6884 ,  A61K31/522 ,  A61K31/573 ,  A61K39/3955 ,  A61K39/39566 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2333/475 ,  G01N2800/122 ,  G01N2800/52

Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.

公开(公告)号：US11226341B2

公开(公告)日：2022-01-18

申请号：US15992115

申请日：2018-05-29

Applicant: GENENTECH, INC.

Inventor： Joseph R. Arron ,  Richard W. Erickson ,  Michelle Freemer ,  Meredith Hazen ,  Guiquan Jia ,  John G. Matthews ,  Wendy Putnam ,  Heleen Scheerens ,  Yanan Zheng

IPC: A61K39/395 ,  G01N33/68 ,  C07K16/28 ,  C07K16/24 ,  C07K16/18 ,  A61K31/522 ,  A61K31/573 ,  A61K45/06

Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.

公开(公告)号：US09684000B2

公开(公告)日：2017-06-20

申请号：US14021698

申请日：2013-09-09

Applicant: Genentech, Inc.

Inventor： Joseph R. Arron ,  Richard W. Erickson ,  Michelle Freemer ,  Meredith Hazen ,  Guiquan Jia ,  John G. Matthews ,  Wendy Putnam ,  Heleen Scheerens ,  Yanan Zheng

IPC: C07K16/00 ,  G01N33/68 ,  C07K16/28 ,  A61K39/395 ,  C07K16/18 ,  A61K31/522 ,  A61K31/573 ,  A61K45/06

CPC classification number: G01N33/6884 ,  A61K31/522 ,  A61K31/573 ,  A61K39/3955 ,  A61K39/39566 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2333/475 ,  G01N2800/122 ,  G01N2800/52

Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.

公开(公告)号：US20140044645A1

公开(公告)日：2014-02-13

申请号：US14021698

申请日：2013-09-09

Applicant: Genentech, Inc.

Inventor： Joseph R. Arron ,  Richard W. Erickson ,  Michelle Freemer ,  Meredith Hazen ,  Guiquan Jia ,  John G. Matthews ,  Wendy Putnam ,  Heleen Scheerens ,  Yanan Zheng

IPC: G01N33/68 ,  A61K39/395 ,  C07K16/18

CPC classification number: G01N33/6884 ,  A61K31/522 ,  A61K31/573 ,  A61K39/3955 ,  A61K39/39566 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2333/475 ,  G01N2800/122 ,  G01N2800/52

Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.

公开(公告)号：US20190120854A1

公开(公告)日：2019-04-25

申请号：US15992115

申请日：2018-05-29

Applicant: GENENTECH, INC.

Inventor： Joseph R. Arron ,  Richard W. Erickson ,  Michelle Freemer ,  Meredith Hazen ,  Guiquan Jia ,  John G. Matthews ,  Wendy Putnam ,  Heleen Scheerens ,  Yanan Zheng

IPC: G01N33/68 ,  C07K16/24 ,  A61K31/573 ,  A61K31/522 ,  A61K45/06 ,  A61K39/395 ,  C07K16/28 ,  C07K16/18

Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.

公开(公告)号：US20140044702A1

公开(公告)日：2014-02-13

申请号：US14021947

申请日：2013-09-09

Applicant: Genentech, Inc.

Inventor： Joseph R. Arron ,  Richard W. Erickson ,  Michelle Freemer ,  Meredith Hazen ,  Guiquan Jia ,  John G. Matthews ,  Wendy Putnam ,  Heleen Scheerens ,  Yanan Zheng

IPC: G01N33/68 ,  A61K31/522 ,  A61K45/06 ,  A61K39/395 ,  A61K31/573

CPC classification number: G01N33/6884 ,  A61K31/522 ,  A61K31/573 ,  A61K39/3955 ,  A61K39/39566 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2333/475 ,  G01N2800/122 ,  G01N2800/52

Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.

Abstract translation: 提供了诊断和治疗与TH2抑制有关的疾病的方法，包括但不限于哮喘。 还提供了选择或鉴定患者以治疗TH2途径抑制剂的某些治疗剂的方法。