公开(公告)号：US20230206644A1

公开(公告)日：2023-06-29

申请号：US18176389

申请日：2023-02-28

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  Paul GIBBONS ,  Yun-Xing CHENG ,  Simon Charles GOODACRE

IPC: G06V20/52 ,  G06M11/00 ,  G08G1/005 ,  G08G1/04 ,  H04N7/18 ,  G06F3/147

CPC classification number: G06V20/53 ,  G06M11/00 ,  G08G1/005 ,  G08G1/04 ,  H04N7/188 ,  G06F3/147 ,  H04N7/181 ,  G09G2380/06

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20200331968A1

公开(公告)日：2020-10-22

申请号：US16816969

申请日：2020-03-12

Applicant: Genentech, Inc.

Inventor： Emily J. HANAN ,  Georgette CASTANEDO ,  Marie Gabrielle BRAUN ,  Keira GARLAND ,  Peter Andrew SMITH ,  Richard PASTOR ,  Paul GIBBONS ,  Yunxing CHENG ,  Guosheng WU ,  Yuhong FU ,  Po-Wai YUEN

IPC: C07K11/02

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：US20230159555A1

公开(公告)日：2023-05-25

申请号：US17814115

申请日：2022-07-21

Applicant: Genentech, Inc.

Inventor： Paul GIBBONS ,  Kwong Wah LAI ,  Christian NILEWSKI ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Bing-Yan ZHU ,  Huifen CHEN

IPC: C07D498/04

CPC classification number: C07D498/04

Abstract: Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B),




solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.

公开(公告)号：US20200339604A1

公开(公告)日：2020-10-29

申请号：US16927436

申请日：2020-07-13

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  Paul GIBBONS ,  Yun-Xing CHENG ,  Simon Charles GOODACRE

IPC: C07D519/00 ,  C07D487/04 ,  A61P11/06

Abstract: Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.