公开(公告)号：US20140115729A1

公开(公告)日：2014-04-24

申请号：US14137927

申请日：2013-12-20

Applicant: Genentech, Inc.

Inventor： Lawren Wu ,  Mercedesz Balazs ,  Hans Brightbill ,  Andrew Chan ,  Yvonne Chen ,  Anan Chuntharapai ,  Mark Dennis ,  Terence Wong

IPC: C07K16/42

CPC classification number: C07K16/4291 ,  A01K67/0278 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/0387 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/73

Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.

Abstract translation: 本申请涉及凋亡性抗IgE抗体，编码它的核酸，其治疗组合物及其在治疗IgE介导的病症中的用途。

公开(公告)号：US20180201679A1

公开(公告)日：2018-07-19

申请号：US15803495

申请日：2017-11-03

Applicant: GENENTECH, INC.

Inventor： Yvonne Chen ,  Mark Dennis ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: C07K16/28 ,  A61K39/395 ,  A61K51/10 ,  A61K47/68 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K39/39541 ,  A61K39/39558 ,  A61K47/6849 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/2896 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92 ,  Y02A50/412

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US10544218B2

公开(公告)日：2020-01-28

申请号：US15349964

申请日：2016-11-11

Applicant: Genentech, Inc.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  C07K16/28 ,  A61K38/05 ,  A61K31/537 ,  C07K16/30 ,  A61K51/10 ,  G01N33/574 ,  A61K45/06 ,  A61K47/68 ,  C07K16/00 ,  C12P21/08 ,  A61K39/00

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20190276550A9

公开(公告)日：2019-09-12

申请号：US13973669

申请日：2013-08-22

Applicant: Genentech, Inc.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20140335107A1

公开(公告)日：2014-11-13

申请号：US14219473

申请日：2014-03-19

Applicant: GENENTECH, INC.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson

IPC: C07K16/28 ,  G01N33/574

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract translation: 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。

公开(公告)号：US20140099260A1

公开(公告)日：2014-04-10

申请号：US13973669

申请日：2013-08-22

Applicant: Genentech, Inc.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2803 ,  A61K31/537 ,  A61K38/05 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6867 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/2896 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/92 ,  G01N33/57492 ,  Y02A50/412 ,  Y02A50/423

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract translation: 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。

公开(公告)号：US11866496B2

公开(公告)日：2024-01-09

申请号：US17234695

申请日：2021-04-19

Applicant: Genentech, Inc.

Inventor： Yvonne Chen ,  Mark Dennis ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K51/10 ,  A61K47/68 ,  C07K17/00 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K39/39541 ,  A61K39/39558 ,  A61K47/6849 ,  A61K51/1027 ,  C07K16/2896 ,  C07K16/3061 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92 ,  Y02A50/30

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US09896506B2

公开(公告)日：2018-02-20

申请号：US14734957

申请日：2015-06-09

Applicant: Genentech, Inc.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K47/68 ,  A61K38/05 ,  A61K45/06 ,  A61K51/10 ,  G01N33/574 ,  A61K31/537 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K31/537 ,  A61K38/05 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6867 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/92 ,  G01N33/57492 ,  Y02A50/412 ,  Y02A50/423

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals, including immunoconjugates comprising anti-CD79b cysteine-engineered antibody huMA79b.v28, and to methods of using those compositions of matter for the same.

公开(公告)号：USRE48558E1

公开(公告)日：2021-05-18

申请号：US15908703

申请日：2018-02-28

Applicant: GENENTECH, INC.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: A61K51/00 ,  A61K39/44 ,  C07K19/00 ,  C07K16/28 ,  A61K47/68 ,  A61K31/537 ,  A61K38/05 ,  A61K39/395 ,  A61K45/06 ,  A61K51/10 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00

Abstract: The present invention is directed to compositions of matter comprising immunoconjugates comprising an anti-CD79b antibody comprising: (i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO: 194), (ii) an HVR-L2 sequence of AASNLES (SEQ ID NO: 195), (iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO: 196), (iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO: 202), (v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO: 203), and (vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO: 204) and to methods of using those compositions of matter for the treatment of hematopoietic tumor in mammals.

公开(公告)号：US10981987B2

公开(公告)日：2021-04-20

申请号：US15803495

申请日：2017-11-03

Applicant: GENENTECH, INC.

Inventor： Yvonne Chen ,  Mark Dennis ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: A61K51/00 ,  A61K39/395 ,  A61K39/40 ,  C07K16/28 ,  C07K16/30 ,  A61K51/10 ,  A61K47/68 ,  C07K16/00 ,  C12P21/08 ,  A61K39/00

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.