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公开(公告)号：US08293929B2
公开(公告)日：2012-10-23
申请号：US12902811
申请日：2010-10-12
申请人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
发明人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
IPC分类号： C07D307/02 , C07C205/00 , C07C233/00
CPC分类号： C07D207/16 , C07D209/52 , C07D211/60 , C07D405/12 , C07D417/06 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
摘要翻译： 本发明涉及可用于生产改性天冬氨酸衍生物如天冬氨酸醛部分的方法和化合物。 天冬氨酸衍生物可用于制备半胱天冬酶抑制剂和/或其前药。
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公开(公告)号：US20110071298A1
公开(公告)日：2011-03-24
申请号：US12902811
申请日：2010-10-12
申请人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
发明人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
IPC分类号： C07D405/12 , C07D417/14 , C07D405/14 , C07D207/16 , C07D401/12
CPC分类号： C07D207/16 , C07D209/52 , C07D211/60 , C07D405/12 , C07D417/06 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
摘要翻译： 本发明涉及可用于生产改性天冬氨酸衍生物如天冬氨酸醛部分的方法和化合物。 天冬氨酸衍生物可用于制备半胱天冬酶抑制剂和/或其前药。
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公开(公告)号：US20090048429A1
公开(公告)日：2009-02-19
申请号：US12074983
申请日：2008-03-07
申请人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
发明人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
IPC分类号： C07K1/02 , C07D405/12
CPC分类号： C07D207/16 , C07D209/52 , C07D211/60 , C07D405/12 , C07D417/06 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
摘要翻译： 本发明涉及可用于生产改性天冬氨酸衍生物如天冬氨酸醛部分的方法和化合物。 天冬氨酸衍生物可用于制备半胱天冬酶抑制剂和/或其前药。
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公开(公告)号：US07381827B2
公开(公告)日：2008-06-03
申请号：US11078147
申请日：2005-03-11
申请人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
发明人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
IPC分类号： C07D207/06 , C07D295/02 , C07D305/00 , C07C239/00
CPC分类号： C07D207/16 , C07D209/52 , C07D211/60 , C07D405/12 , C07D417/06 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
摘要翻译： 本发明涉及可用于生产改性天冬氨酸衍生物如天冬氨酸醛部分的方法和化合物。 天冬氨酸衍生物可用于制备半胱天冬酶抑制剂和/或其前药。
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公开(公告)号：US07834200B2
公开(公告)日：2010-11-16
申请号：US12074983
申请日：2008-03-07
申请人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
发明人： Gerald J. Tanoury , Minzhang Chen , Andrew D. Jones , Philip L. Nyce , Martin Trudeau , David J. Guerin , John R. Snoonian
IPC分类号： C07D307/56
CPC分类号： C07D207/16 , C07D209/52 , C07D211/60 , C07D405/12 , C07D417/06 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
摘要翻译： 本发明涉及可用于生产改性天冬氨酸衍生物如天冬氨酸醛部分的方法和化合物。 天冬氨酸衍生物可用于制备半胱天冬酶抑制剂和/或其前药。
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公开(公告)号：US20060020016A1
公开(公告)日：2006-01-26
申请号：US11078147
申请日：2005-03-11
申请人： Gerald Tanoury , Minzhang Chen , Andrew Jones , Philip Nyce , Martin Trudeau , David Guerin , John Snoonian
发明人： Gerald Tanoury , Minzhang Chen , Andrew Jones , Philip Nyce , Martin Trudeau , David Guerin , John Snoonian
IPC分类号： A61K31/4025 , C07D405/02
CPC分类号： C07D207/16 , C07D209/52 , C07D211/60 , C07D405/12 , C07D417/06 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
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![Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide](/abs-image/US/2013/04/02/US08410274B2/abs.jpg.150x150.jpg)
公开(公告)号：US08410274B2
公开(公告)日：2013-04-02
申请号：US13358778
申请日：2012-01-26
申请人： Patricia Hurter , William Rowe , Christopher Ryan Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
发明人： Patricia Hurter , William Rowe , Christopher Ryan Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
IPC分类号： C07D215/38
CPC分类号： A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
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![Solid forms of N-[2,4-BIS(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide](/abs-image/US/2011/03/17/US20110064811A1/abs.jpg.150x150.jpg)
8.发明申请Solid forms of N-[2,4-BIS(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 审中-公开固体形式的N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺公开(公告)号：US20110064811A1
公开(公告)日：2011-03-17
申请号：US11647505
申请日：2006-12-28
申请人： Patricia Hurter , William Rowe , Christopher R. Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
发明人： Patricia Hurter , William Rowe , Christopher R. Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
IPC分类号： A61K9/14 , C07D215/56 , A61K31/47 , A61P3/10 , A61P11/00 , A61P7/10 , A61P3/00 , A61P35/00 , A61P25/28 , A61P25/16 , A61P27/04 , A61P7/00
CPC分类号： A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
摘要翻译： 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
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公开(公告)号：US20090030051A1
公开(公告)日：2009-01-29
申请号：US12221921
申请日：2008-08-07
申请人： Dean Stamos , Martin Trudeau , Randy S. Bethiel , Steven M. Ronkin , Michael C. Badia , Jeffrey O. Saunders
发明人： Dean Stamos , Martin Trudeau , Randy S. Bethiel , Steven M. Ronkin , Michael C. Badia , Jeffrey O. Saunders
IPC分类号： A61K31/421 , A61P37/02 , A61P9/00 , A61P35/00
CPC分类号： C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653
摘要： The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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公开(公告)号：US07087642B2
公开(公告)日：2006-08-08
申请号：US10287405
申请日：2002-11-04
申请人： Dean Stamos , Martin Trudeau , Scott Bethiel , Steven Ronkin , Michael Badia , Jeffrey Saunders
发明人： Dean Stamos , Martin Trudeau , Scott Bethiel , Steven Ronkin , Michael Badia , Jeffrey Saunders
IPC分类号： A61K47/00 , A61K31/27 , C07C229/00 , C07C255/00
CPC分类号： C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653
摘要： The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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